1.Changing Role of Nuclear Medicine for the Evaluation of Focal Hepatic Tumors: From Lesion Detection to Tissue Characterization.
Korean Journal of Nuclear Medicine 1998;32(3):211-224
The role of scintigraphic imaging has moved from the detection of lesions to the tissue-specific characterization of lesions over the past 2 decades. Major advances in nuclear medicine imaging include: 1) positron imaging, 2) improved instrumentation, such as the use of multidetector (dual or triple head) gamma cameras for single photon emission computed tomography, and 3) development of numerous new radiopharmaceuticals for positron or single photon imaging ( labeled glucose analogue, amino acids, fatty acids, hormones, drugs, receptor ligands, monoclonal antibodies, etc). These advanced have resulted in a significantly improved efficacy of radionuclide techniques for the evaluation of various of focal gepatic tumors is reviewed in this article with an emphasis on the clinical applications of various tracer studies and imaging findings.
Amino Acids
;
Antibodies, Monoclonal
;
Carcinoma, Hepatocellular
;
Electrons
;
Fatty Acids
;
Gamma Cameras
;
Glucose
;
Hemangioma
;
Ligands
;
Nuclear Medicine*
;
Radionuclide Imaging
;
Radiopharmaceuticals
;
Tomography, Emission-Computed, Single-Photon
2.Metastatic Omental Hepatocellular Carcinoma: Two Cases Report.
Jae Chun CHANG ; Won Kyu PARK ; Mi Jin KIM
Journal of the Korean Radiological Society 1995;33(3):403-406
We report metastatic omental hepatocellular carcinoma in two patients with post-lobectomy hepatocellular carcinoma who have had previous abdominal surgery or the rupture of hepatocellular carcinoma. Ometal metastatic masses were similar to primary masses of the liver in pathologic findings as well as in radiologic findings.
Carcinoma, Hepatocellular*
;
Humans
;
Liver
;
Rupture
3.Characterization of MACS Isolated Cells from Differentiated Human ES Cells.
Jae Won CHO ; Chun Kyu LIM ; Mi Ra SHIN ; Kyoung Hee BANG ; Mi Kyoung KOONG ; Jin Hyun JUN
Korean Journal of Fertility and Sterility 2006;33(3):171-178
OBJECTIVE: Human embryonic stem (ES) cells have a great potential in regenerative medicine and tissue engineering. The human ES cells could be differentiated into specific cell types by treatments of growth factors and alterations of gene expressions. However, the efficacy of guided differentiation and isolation of specific cells are still low. In this study, we characterized isolated cells from differentiated human ES cells by magnetic activated cell sorting (MACS) system using specific antibodies to cell surface markers. METHODS: The undifferentiated hES cells (Miz-hESC4) were sub-cultured by mechanical isolation of colonies and embryoid bodies were spontaneously differentiated with DMEM containing 10% FBS for 2 weeks. The differentiated cells were isolated to positive and negative cells with MACS system using CD34, human epithelial antigen (HEA) and human fibroblast (HFB) antibodies, respectively. Observation of morphological changes and analysis of marker genes expression were performed during further culture of MACS isolated cells for 4 weeks. RESULTS: Morphology of the CD34 positive cells was firstly round, and then it was changed to small polygonal shape after further culture. The HEA positive cells showed large polygonal, and the HFB positive spindle shape. In RT-PCR analysis of marker genes, the CD34 and HFB positive cells expressed endodermal and mesodermal genes, and HEA positive cells expressed ectodermal genes such as NESTIN and NF68KD. The marker genes expression pattern of CD34 positive cells changed during the extension of culture time. CONCLUSION: Our results showed the possibility of successful isolation of specific cells by MACS system from undirected differentiated human ES cells. Thus, MACS system and marker antibodies for specific cell types might be useful for guided differentiation and isolation of specific cells from human ES cells.
Antibodies
;
Ectoderm
;
Embryoid Bodies
;
Endoderm
;
Fibroblasts
;
Gene Expression
;
Humans*
;
Intercellular Signaling Peptides and Proteins
;
Mesoderm
;
Nestin
;
Regenerative Medicine
;
Tissue Engineering
4.Mechanisms of Granulosa Cell Transition from Proliferation to Differentiation During the Ovulatory Process in Rodents: Role of Interferon-alpha System.
Sang Young CHUN ; Mee Jin JEON ; You Mi SEO ; Tae Sung KIM
Korean Journal of Fertility and Sterility 2006;33(2):75-83
No abstract available.
Female
;
Granulosa Cells*
;
Interferon-alpha*
;
Rodentia*
5.Development of a Tool for Predicting Nursing Times in Occupational Accident Patients.
Jin Joo OH ; Chun Mi KIM ; Jeong Myung CHOI
Korean Journal of Occupational Health Nursing 2010;19(1):5-13
PURPOSE: This study aims to develop a tool to predict occupational health patients' nursing needs or nursing time. METHOD: A tool was composed based on the materials and opinion of experts, and to verify the reliability and validity of the tool, nursing time of total 311 inpatients in 2 occupational health hospitals were surveyed. RESULTS: The developed tool was total 151 items and composed of physical function, cognitive function, communication, emotional and disturbance behavior, nursing skill, and rehabilitation need. The reliability of the tool was high, showing Cronbach's alpha coefficient of 0.95. But several items should be deleted for low corrected item-total correlation. According to the multiple regression analysis, physical function and rehabilitation need were shown to be the most powerful predictive variables for nursing time. CONCLUSION: The developed tool was appeared to have high reliability and validity. But further refinement of the tool is needed.
Accidents, Occupational
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Humans
;
Inpatients
;
Occupational Health
;
Reproducibility of Results
6.Quality Dimension of Long Term Care Hospital.
Chun Mi KIM ; Ji Yun LEE ; Ryeo Jin KO
Journal of Korean Academy of Community Health Nursing 2009;20(2):243-250
PURPOSE: This is a qualitative study to identify dimensions of long-term care hospital care quality that provide high-level medical services for long-term care patients in Korea. METHODS: Service consumers and providers were interviewed, and collected data were analyzed into thesis, type and dimension. The focus group method was applied to two provider groups and individual interview was applied to two persons who had experienced a long-term care hospital. RESULTS: The results of analyzing the comsumers and providers was integrated into 8 dimensions: physical environment, staff, clinical care and nursing, multiplicity of activity program, atmosphere, interaction with family, nutrition, and quality improvement system. CONCLUSION: The dimensions of long-term care hospital care quality from this study can be used as a basis of quality indicators. Quantitative studies to test these dimensions are required for establishing quality management systems.
Atmosphere
;
Focus Groups
;
Humans
;
Korea
;
Long-Term Care*
;
Nursing
;
Qualitative Research
;
Quality Improvement
;
Quality Indicators, Health Care
7.Congenital Anonychia of the Toes with Absence of Underlying Phalangeal Bones.
Seong Jin KIM ; Mi Hye LIM ; Seung Chul LEE ; Young Ho WON ; Inn Ki CHUN
Annals of Dermatology 1997;9(3):188-190
Congenital absence of nails usually occur as a rare isolated anomaly or combined with other ectodermal defects. This anomaly is regarded as an inherited disorder either dominantly or recessively but quite a few cases were reported as sporadically developed. The patient was a 2-month-old girl who had no nails on both her 2nd, 3rd toes but had rudimentary nails on her left big toe and both 4th toes at birth. We could not find any other congenital deformity, any family history of inherited diseases related to anonychia. Radiological findings revealed no visualization of both 4th distal phalanges, only. We report this case as congenital anonychia of a sporadic type which may have developed independently from an underlying bone abnormality. We also review other reported cases in the literature.
Congenital Abnormalities
;
Ectoderm
;
Female
;
Hallux
;
Humans
;
Infant
;
Parturition
;
Toes*
8.Control Mechanisms of Ovarian Follicle Development by Follicle Stimulating Hormone and Pituitary Adenylate Cyclase-activating Polypeptide.
Yu Il LEE ; Jin Ok SHIN ; Mi Young KIM ; Sang Young CHUN
Korean Journal of Fertility and Sterility 2006;33(1):15-24
OBJECTIVE: Pituitary adenylate cyclase-activating polypeptide (PACAP), a novel hypothalamic neuropeptide, has been suggested to play a role in ovarian folliculogenesis. The present study evaluated the effect of PACAP on the growth of preantral follicles. METHODS: Preantral follicles were mechanically isolated from ovaries of 21-day-old rats and cultured in groups for 3 days in serum-free medium in the absence or presence of PACAP-38 (10-6 M). RESULTS: Treatment with PACAP-38 resulted in an increase in follicle diameter by 75% whereas treatment with follicle stimulating hormone (FSH) increased follicle diameter by 65%. PACAP-38 treatment enhanced the granulosa cell proliferation as measured by thymidine incorporation analysis. Furthermore, the production of progesterone by cultured granulosa cells and GFSHR-17 cell line was stimulated by PACAP-38. Interestingly, PACAP enhanced FSH action on stimulation of SF-1 and aromatase gene expression. CONCLUSION: The present results demonstrate that PACAP stimulated preantral follicle growth by potentiating proliferation and by stimulating steroidogenesis.
Animals
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Aromatase
;
Cell Line
;
Female
;
Follicle Stimulating Hormone*
;
Gene Expression
;
Granulosa Cells
;
Neuropeptides
;
Ovarian Follicle*
;
Ovary
;
Pituitary Adenylate Cyclase-Activating Polypeptide*
;
Progesterone
;
Rats
;
Thymidine
9.Effect of Hydrosalpingeal Fluid on the Implantation in-vitro in a Murine Model.
Jin Hyun JUN ; Chun Kyu LIM ; Soo Kyung KIM ; Mi Kyoung KOONG ; Inn Soo KANG
Korean Journal of Fertility and Sterility 2000;27(2):159-164
No abstract available.
10.The Prevalence of Asthma, Allergic Rhinitis, and Atopic Dermatitis in Elementary School Students according to the Body Mass Index.
Chong Mi CHANG ; Sang Hee CHUN ; Jin Yi CHOI
Journal of Korean Academy of Community Health Nursing 2015;26(3):230-237
PURPOSE: This study aimed to assess the prevalence of asthma, allergic rhinitis, and atopic dermatitis in elementary school students according to thebody mass index. METHODS: This study was conducted as cross-sectional descriptive research using a structured questionnaire. Data were collected from 6,398 students at 15 elementary schools located in Y City in Korea. The cross-sectional survey used the Korean version of International Study of Asthma and Allergies in Childhood questionnaire. Logistic regression analysis was performed to estimate the odds ratios of body mass index. RESULTS: The symptom prevalence of asthma, allergic rhinitis, and atopic dermatitis in the last 12 months was 12.4%, 49.5%, and 24.5%, respectively. The symptom prevalence of asthma was significantly higher in the obesity group. The number of those without any asthma symptom in lifetime was significantly smaller in the overweight (OR=0.70, p=.004) and obesity (OR=0.57, p=.005) groups than in the healthy weight group. CONCLUSION: These results suggest that asthma, allergic rhinitis, and atopic dermatitis prevention programs for elementary school students should include weight control intervention.
Asthma*
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Body Mass Index*
;
Cross-Sectional Studies
;
Dermatitis
;
Dermatitis, Atopic*
;
Humans
;
Hypersensitivity
;
Korea
;
Logistic Models
;
Obesity
;
Odds Ratio
;
Overweight
;
Prevalence*
;
Rhinitis*