PURPOSE: To evaluate mammographic and sonographic breast parenchymal changes and the risk of breast cancer in women on hormonal replacement therapy (HRT). MATERIAL AND METHODS: The study group consisted of 50 patients examined with serial mammograms and/or ultrasonograms during HRT. The control group consisted of 50 patients examined with serial mammogram for a routine health check. Mammographic parenchymal changes in both the study and control groups and so- nographic findings of 27/50 patients in study group were evaluated. RESULTS: Follow-up mammogram of the control group showed no interval change or slight evolution of parenchyma with increasing age, but the study group showed increasing parenchymal densities. Most frequently encountered finding on SOhogram in 11 women treated by estrogen alone, was ductal dilatation (7cases ;64%), whereas in 16 women treated by estrogen and progesteron it was ductal epithelial hyperplasia (8 cases; 50%). Overall, four breast cancers developed;one infiltrating ductal carcinoma and three ductal carcinoma in situ. CONCLUSION: HRT causes the changes of breast parenchyma on mammogram and sonogram of postmenopausal women, and increases the risk of developing breast cancer. Therefore, careful and regular examination should be followed in those on postmenopausal HRT.
Breast Neoplasms ; Breast* ; Carcinoma, Ductal ; Carcinoma, Intraductal, Noninfiltrating ; Dilatation ; Estrogens ; Female ; Follow-Up Studies ; Humans ; Hyperplasia ; Ultrasonography

PURPOSE: Tubular adenoma (TA) is known as a rare lesion of the breast which is difficult to diagnosis preoperatively because of its rarity and similarity to fibroadenoma. Hence, our purpose is to suggest the characteristic sonographic features for its correct diagnosis. MATERIALS AND METHODS: We retrospectively analyzed the clinical data and mammographic and sonographic findings. of seven patients(mean age, 23) who during theprevious five years had presented at our hospital with pathologically-proven tubular adenomas. RESULTS: TA was misdiagnosed as fibroadenoma, since on physical examination of these young females, the lesions presented apalpable, non-tender mass. Mammographically, they showed a well defined mass similar to fibroadenoma. however, Sonographic findings were characteristic of TA and compared to fibroadenoma, showed a well demarcated and smooth bordered mass with transverse long axis, posterior enhancement and homogeneous lower internal echogenecity. Nocase showed lateral wall refractive shadowing. CONCLUSION: In young females, the clinical and mammographic findings of TA are similar to those of fibroadenoma. However, sonographic findings of TA can, be helpful in the differential diagnosis of this entity and fibroadenoma.
Adenoma* ; Axis, Cervical Vertebra ; Breast* ; Diagnosis ; Female ; Fibroadenoma ; Humans ; Physical Examination ; Retrospective Studies ; Shadowing (Histology) ; Ultrasonography

PURPOSE: We wanted to evaluate the barium enema findings of milk allergy in infants. MATERIALS AND METHODS: Retrospective evaluation of the plain abdominal radiography and barium enema findings was performed in fifteen young infants suffering with milk allergy. The presence of gaseous distension, rectal gas, paralytic ileus and mechanical obstruction was evaluated on the plain radiography. The presence of spasm, a transitional zone, a reversed rectosigmoid index and mucosal irregularity was analyzed on the barium enema; the presence of barium retention was also evaluated on 24-hour-delayed plain radiography. RESULTS: Paralytic ileus was the most common finding on the plain radiography (93%). On the barium enema, continuous spasm of the colon, ranging from the rectum to the descending colon, was revealed in ten infants (67%). A transitional zone was observed in one infant and a reversed rectosigmoid index was revealed in four. Mucosal irregularity was observed in two infants. Barium retention was demonstrated in 11 of fifteen cases: throughout the entire colon (n = 3), from the rectum to the descending colon (n = 7), and up to the transverse colon (n = 1). CONCLUSION: The most common barium enema finding of milk allergy in infants was spasm of the distal colon. The other findings were a transitional zone, a reversed rectosigmoid index, mucosal irregularity and barium retention.
Barium* ; Colitis ; Colon ; Colon, Descending ; Colon, Transverse ; Enema* ; Humans ; Infant* ; Intestinal Pseudo-Obstruction ; Milk Hypersensitivity* ; Milk* ; Radiography ; Radiography, Abdominal ; Rectum ; Retrospective Studies ; Spasm

PURPOSE: We wanted to evaluate the barium enema findings of milk allergy in infants. MATERIALS AND METHODS: Retrospective evaluation of the plain abdominal radiography and barium enema findings was performed in fifteen young infants suffering with milk allergy. The presence of gaseous distension, rectal gas, paralytic ileus and mechanical obstruction was evaluated on the plain radiography. The presence of spasm, a transitional zone, a reversed rectosigmoid index and mucosal irregularity was analyzed on the barium enema; the presence of barium retention was also evaluated on 24-hour-delayed plain radiography. RESULTS: Paralytic ileus was the most common finding on the plain radiography (93%). On the barium enema, continuous spasm of the colon, ranging from the rectum to the descending colon, was revealed in ten infants (67%). A transitional zone was observed in one infant and a reversed rectosigmoid index was revealed in four. Mucosal irregularity was observed in two infants. Barium retention was demonstrated in 11 of fifteen cases: throughout the entire colon (n = 3), from the rectum to the descending colon (n = 7), and up to the transverse colon (n = 1). CONCLUSION: The most common barium enema finding of milk allergy in infants was spasm of the distal colon. The other findings were a transitional zone, a reversed rectosigmoid index, mucosal irregularity and barium retention.
Barium* ; Colitis ; Colon ; Colon, Descending ; Colon, Transverse ; Enema* ; Humans ; Infant* ; Intestinal Pseudo-Obstruction ; Milk Hypersensitivity* ; Milk* ; Radiography ; Radiography, Abdominal ; Rectum ; Retrospective Studies ; Spasm

PURPOSE: This study was aimed to develop a WBI(Web Based Instruction) program on safety for 3rd grade elementary school students and to test the effects of it. METHOD: The WBI program was developed using Macromedia flash MX, Adobe Illustrator 10.0 and Adobe Photoshop 7.0. The web site was http://www.safeschool. co.kr. The effect of it was tested from Mar 24, to Apr 30, 2003. The subjects were 144 students enrolled in the 3rd grade of an elementary school in Gyungju. The experimental group received the WBI program lessons while each control group received textbook-based lessons with visual presenters and maps, 3 times. Data was analyzed with descriptive statistics, and x2 test, t-test, and repeated measure ANOVA. RESULT: First, the WBI group reported a longer effect on knowledge and practice of accident prevention than the textbook-based lessons, indicating that the WBI is more effective. Second, the WBI group was better motivated to learn the accident prevention lessons, showing that the WBI is effective. As a result, the WBI group had total longer effects on knowledge, practice and motivation of accident prevention than the textbook-based instruction. CONCLUSION: We recommend that this WBI program be used in each class to provide more effective safety instruction in elementary schools.
*Accident Prevention ; Child ; *Computer-Assisted Instruction ; Female ; Humans ; *Internet ; Male ; Safety ; School Health Services

The aim of this study was to determine the usefulness of quantitative analysis of multiphasic dynamic contrast-enhanced magnetic resonance (MR) imaging in differentiating early homogeneously enhancing hemangiomas from hepatocellular carcinomas (HCCs). Four-phased dynamic MR imaging at 10 sec (first phase of dynamic contrast-enhanced imaging, P1), 35 sec (second phase, P2), 60 sec (third phase, P3) and 300 sec (delay phase, P4) immediately after intravenous administration of 0.1 mmol/kg Gadolinium-DTPA was obtained with 1.5-T unit with breath-hold multisection FLASH (fast low angle-shot) sequence (TR/TE, 113-130 msec/4.1 msec; flip angle, 80 degrees). Thirty-three HCCs and 18 hemangiomas, homogeneously enhanced on P1, were included in the study. The images were evaluated quantitatively (SNR, signal-to-noise ratio; and CNR, contrast- to- noise ratio of lesions). Quantitatively, mean CNR was higher for hemangiomas than for HCCs on all phases, and the difference in CNRs between hemangioma and HCCs was statistically significant on P3 and P4 (p < 0.0001). When the cutoff for CNR was set at a value of 7.00 on P3 and 1.00 on P4, sensitivity, specificity and accuracy were 94.4%, 93.9%, and 94.1% on P3, and 94.4%, 81.8%, and 86.3% on P4, respectively. There was no statistically significant difference in SNRs between HCC and hemangioma. The differential diagnosis between early, homogeneously enhancing hemangiomas and HCCs was more confidently made with CNRs of lesions on P3 and P4 in dynamic contrast-enhanced MR imaging.
Adult ; Aged ; Carcinoma, Hepatocellular/diagnosis* ; Contrast Media ; Diagnosis, Differential ; Female ; Hemangioma/diagnosis* ; Human ; Image Enhancement ; Liver Neoplasms/diagnosis* ; Magnetic Resonance Imaging/methods* ; Male ; Middle Age

PURPOSE: To evaluate the usefulness and the accuracy of CT-discography in lumbar disc disease by analyzing the findings of CT-discogram and types of evoked pain during the procedure. MATERIALS AND METHODS: CT-discograms were retrospectively evaluated in 47 intervertebral discs of 20 patients with multilevel involvement of lumbardisc diseases. In 28 herniated discs confirmed at surgery, the findings of CT-discogram (28 disc levels/20 patients), MRI(23/16) and CT(21/15) were comparatively analysed. The type of pain after infusion of contrast mediaduring CT-discography was compared with that prior to the procedure. RESULTS: The accuracy for determining typesof the herniated lumbar disc when compared with postoperative results was 96.4%(27 discs/28 discs) in the CT-discogram, 82.6%(19 discs/23 discs) in MRI and 71.4%(15 discs/21 discs) in the CT scan. Pains encountered during discography were radiating pain in 12 discs and back pain in 24 discs. CT-discography was especially helpful in 10 patients with multilevel involvement of the lumbar disc diseases to evaluate the exact location of diseased disc(s) that provoked the pain. CONCLUSION: CT-discography is a highly accurate method in diagnosis ofthe herniated lumbar intervertebral discs and is very useful in determining the precise location related to the development of pain in such cases.
Back Pain ; Diagnosis ; Humans ; Intervertebral Disc ; Intervertebral Disc Displacement ; Magnetic Resonance Imaging ; Retrospective Studies ; Spine ; Tomography, X-Ray Computed

Contrast enhancement during the dynamic MR imaging is important for the detection and characterization of focal liver lesions. The purpose of this study was to determine whether or not a timing examination with a injection of a 1.0-mL bolus of gadopentetate dimeglumine into the antecubital vein followed by rapid dynamic scanning and measurement of signal intensity of the aorta could help to obtain proper arterial-dominant phase images for the characterization of focal hepatic lesions during subsequent multiphase dynamic MR imaging. The imaging delay to acquisition of the first gadolinium-enhanced image for multiphase dynamic MR imaging was set to equal the time to peak aortic enhancement during the test examination. The first contrast-enhanced images of 80 patients with 160 focal liver lesions (hepatocellular carcinoma, n = 79; cavernous hemangioma, n = 51; metastatic tumor, n = 30) were then retrospectively reviewed. Peak aortic enhancement occurred between 10 and 28 seconds (mean, 16.5 seconds +/- 3.1) after starting the infusion of contrast material in 80 patients during the test-examination. Depending on the findings of intrahepatic vascular enhancement on the full-scale dynamic images, hepatic arterial phase (n = 11, 14%) or sinusoid phase (n = 65, 81%) imaging was obtained during the first gadolinium-enhanced acquisition in 76 (95%) of 80 patients. Three different lesions were well characterized and easily distinguished from each other (p < .0001) on the first-phase images depending on their enhancement pattern. In the majority of patients, timing examination with test-bolus injection was helpful in obtaining qualified images for the characterization of various focal lesions.
Adult ; Aged ; Aged, 80 and over ; Female ; Hepatic Artery/pathology ; Human ; Image Enhancement* ; Liver/pathology* ; Liver Neoplasms/secondary ; Liver Neoplasms/diagnosis ; Magnetic Resonance Imaging ; Male ; Middle Age ; Time Factors

PURPOSE: To evaluate the usefulness of quantitative analysis of the degree of enhancement in dynamic MRimaging used to differentiate dysplastic nodule (DN) from small hepatocellular carcinoma (HCC), both of which showhigh signal intensity on T1-weighted images. MATERIALS AND METHODS: From 26 small HCCs and 71 DNs, all of whichshowed homogeneous high signal intensity on T1-weighted images among 42 patients with liver cirrhosis, weselected 16 small HCCs and 10 DNs of more than 1cm in diameter which were diagnosed by biopsy and follow-up imaging. Dynamic MR imaging of the entire liver was obtained using the breath-hold technique at postinjection 10sec. (phase 1), 35 sec. (phase 2), 60 sec. (phase 3), and 5 min. (delayed) after intravenous manual injection ofGd-DTPA (0.1 mmol/kg) at a velocity of 3-4 cc/sec. Nodule-to-liver contrast-to-noise ratios (CNR) during eachphase were calculated by measurement of the region of interest. RESULTS: On precontrast T1-weighted images, themean CNR of small HCCs was 2.873, and that of DNs was 3.854, there was thus no significant statistical difference(p>0.01). On postcontrast images, the CNR of small HCCs during each phase was 5.565, 3.790, 1.704, and 1.282, withpeak CNR phase 1 and a mostly decreasing trend thereafter. However, the CNR of DNs during each phase was 3.053,1.561, 0.919, and 1.038 ; there was thus showed no significant increase during phase 1 in comparison with the CNRsseen on precontrast images. During the precontrast stage and phase 1, the average difference in CNR was 2.691 forsmall HCCs and 0.801 for DNs the difference was thus significant (p<0.01). CONCLUSION: Quantitative analysis ofCNR, reflecting the degree of nodule-to-liver enhancement in dynamic MR imaging, was found to be useful for thedifferentiation of small HCCs from DNs, both of which show high signal intensity on T1-weighted images.
Biopsy ; Carcinoma, Hepatocellular* ; Follow-Up Studies ; Humans ; Liver ; Liver Cirrhosis ; Magnetic Resonance Imaging*

Ovarian leiomyoma is a rare mesenchymal tumor, accounting for only 1% of all benign ovarian neoplasm. Most patients are asymptomatic and the tumors are usually found incidentally during operation or at autopsies. Ovarian adenofibroma is a rare benign tumor which originates from the germinal lining and the stroma of the ovary. This tumor may be solid, semisolid or cystic, depending on the relative amount of the epithelial and stromal component. We have experienced a case of ovarian leiomyoma accompanied with ovarian serous adenofibroma in a 42-year-old woman and report this case with a brief review of literature.
Adenofibroma* ; Adult ; Autopsy ; Female ; Humans ; Leiomyoma* ; Ovarian Neoplasms ; Ovary