1.Diagnostic Significance in Case with Growth Hormone Deficient Dwarfs.
Duk Hi KIM ; Mi Jung PARK ; Yan Kyu LEE
Journal of the Korean Pediatric Society 1990;33(12):1699-1704
No abstract available.
Growth Hormone*
2.A Case of Polygrandular Automune type II syndrome associated empty sella.
Jin Soo KIM ; Mi Duk LEE ; Hong Seung KIM ; Choon Hee CHUNG
Journal of Korean Society of Endocrinology 1998;13(2):295-300
The polyglandular autoimmune(PGA) syndrome designate as the dysfimction of endocrine and nonendocrine systems involving two or more organs on the basis of an autoimmune mechanism. There are 3 types of PGA syndrome and their etiology or pathogenesis is still not complete by understood. Type I PGA is present in the patients who have at least two of the triad of Addison's disease, hypopacathyroidism, and chronic mucocutaneous candidiasis. Type II PGA is present in the those who have Addisons disease with autoimmune thyroid disease and/or insulin dependent diabetes mellitus, but who do not have hypoparathyroidism or candidiasis. Type III PGA is present in the one who have autoimmune thyroid disease, without Addisons disease, but with another autoimmune disease report a case of autoimmune polyglandular syndrome type II in a seventy-three years old female patient who had primary adrenal insufficiency, primary hypothyroidism, and empty sella, pulmonary tuberculosis.
Addison Disease
;
Autoimmune Diseases
;
Candidiasis
;
Candidiasis, Chronic Mucocutaneous
;
Diabetes Mellitus
;
Female
;
Humans
;
Hypoparathyroidism
;
Hypothyroidism
;
Insulin
;
Polyendocrinopathies, Autoimmune
;
Thyroid Diseases
;
Tuberculosis, Pulmonary
3.Quantification of human urinary growth hormone and its clinical significance in the diagnosis of growth hormone deficiency.
Seung Ryul LEE ; Ho Seong KIM ; Duk Hi KIM ; Chang Mi KIM
Journal of the Korean Pediatric Society 1992;35(5):595-601
No abstract available.
Diagnosis*
;
Growth Hormone*
;
Humans*
4.Clinical Characteristics in Korean Patients with Insulin Receptor Antibody Positive Acanthosis Nigricans.
Hong Seung KIM ; Choon Hee CHUNG ; Young Goo SHIN ; Mi Duk LEE ; Young Joon WON
Journal of Korean Society of Endocrinology 1998;13(3):410-416
BACKGROUND: Insulin resistance syndrome shows extreme insulin resistance and is associated with acanthosis nigricans. We can differentiate it into type A insulin resistance that has insulin receptor defect, and type B insulin resistance due to insulin receptor autoantibody. Type B insulin resistance was firstly described by Kahn in 1976. It was often found in adult female and showed autoimmune characteristics. As clinical characteristics, there are hyperglycemia, hypoglycemia, hyperinsulinemia, extreme insulin resistance and acanthosis nigricans. METHODS: We investigated 17 insulin receptor autoantibody positive cases and 8 cases of normal control who had visited Wonju Christian Hospital from October 1994 to December 1995. Among insulin receptor autoantibody positive subject, male was 4 cases and female 13 cases. Their mean age was 42.2. We compared patients who had insulin receptor antibody positive acanthosis nigricans(IRA) with normal controls. IRA patients were 6 cases(35.3%) of nomal glucose tolerance, 11 cases(64.7%) of abnormal glucose tolerance including overt diabetes mellitus. RESULTS: The 11 cases(64.7%) among IRA patrents were obese and 13 cases(76.5%) had hyperininsulinemia. In IRA patients, mean serum insulin concentration during oral glucose tolerance test was 202.1mU/mL and it was greater than 46.3 of normal controls. Insulin sensitivity in 1.79mg/L * mM * xmU * min normal controls was higher than 0.74mg/L * mM * min of IRA patients. CONCLUSION: IRA patients showed abnormal glucose tolerance including overt diabetes millitus, severe insulin resistance, hyperinsulinemia and obesity.
Acanthosis Nigricans*
;
Adult
;
Diabetes Mellitus
;
Female
;
Gangwon-do
;
Glucose
;
Glucose Tolerance Test
;
Humans
;
Hyperglycemia
;
Hyperinsulinism
;
Hypoglycemia
;
Insulin Resistance
;
Insulin*
;
Male
;
Obesity
;
Receptor, Insulin*
5.Characteristics of Childhood Diabetes.
Mi Jung PARK ; Wook CHANG ; Hyun Chul LEE ; Duk Hi KIM ; Ho Seoung KIM
Journal of the Korean Pediatric Society 1995;38(8):1116-1123
No abstract available.
6.A case of sertoli - leydig cell tumor.
Jung Yeon CHOI ; Hye Mi LEE ; Sung Soo CHAE ; Yoo Duk CHOI
Korean Journal of Obstetrics and Gynecology 1993;36(7):2465-2470
No abstract available.
Leydig Cell Tumor*
7.A Case of Adrenocortical Carcinoma with Remarkably High Concentrations of 11-dexycortisol.
Hong Seung KIM ; Choon Hee CHUNG ; Mee Yeon CHO ; Mi Duk LEE ; Young Wook KIM ; Yun Mi KIM
Journal of Korean Society of Endocrinology 1998;13(2):271-279
The adrenocartical carcinoma is a rare tumor with an estimated incidence of 1 case per 1,700,000 population. Despite its rarity, a large number of investigators have studied this neoplasm for the following two reasons. The First is the occasional difficulty of differentiation between careinoma and adenoma at the time of initial surgery, even by histopathologic examination. The other is its unique feature of corticosteroidogenesis. Steroid metabolism of adrenocortieal carcinoma is characterized by its low efficiency of steroid production due to deficiency of steroidogenic enzyme. The deficieney of 11 B-hydroxylase has been indieated in case of adrenoeortical carcinoma by several investigators. In this study, the serum level of cortisol was within normal range, but the serum level of 11-deoxycortisol was 50 times higher than normal. After the removal of tumor, the serum level of ll-deoxycortisol was markedly decm. In conclusion, the results from the this case suggest that measurement of serum 11-deoxy- cortisol may be a useful tool in the diagnosis and follow-up of adrenocortical carcinoma.
Adenoma
;
Adrenocortical Carcinoma*
;
Cortodoxone
;
Diagnosis
;
Follow-Up Studies
;
Humans
;
Hydrocortisone
;
Incidence
;
Metabolism
;
Reference Values
;
Research Personnel
8.A Case of Renal Hypoplasia with Renovascular Hypertension.
Sang Doo LEE ; Jae Hee PARK ; Jae Beom LEE ; Yun Duk YOO ; Byoung Hwa LEE ; Mi Sun LEE
Journal of the Korean Pediatric Society 1995;38(11):1565-1570
No abstract available.
Hypertension, Renovascular*
9.A Case of Primary Jejunal Adenocarcinoma.
Young Jin KANG ; Hee Ug PARK ; Jong Han OK ; Tae Duk YUN ; Dall Duk SUH ; Mi Kyoung KIM ; Jin Youn LEE
Korean Journal of Gastrointestinal Endoscopy 1996;16(3):505-509
The occurrence of the small intestinal adenocarcinoma is infrequent and the primary adenocarcinoma of the jejunum is rare. The survival of adenocarcinoma of the small bowel does not improve over the past three decades. Although symptoms appeared to be of long duration, most patients were diagnosed with advanced disease. All reports agree that these tumors are difficult to achieve good examination of the small bowel by both clinician and radiologist, so it cause a significant delay in diagnosis. The survival of these tumors appear to correlate with stage at presentation, and therefore early and aggressive diagnostic intervention seems to improve the outlook. We report a case of primary jejunal adenocarcinoma assoeiated with iron deficiency anemia with literatures review.
Adenocarcinoma*
;
Anemia, Iron-Deficiency
;
Diagnosis
;
Humans
;
Jejunum
10.Mitochondrial Toxins and Healthy Lifestyle Meet at the Crossroad of Hormesis
Diabetes & Metabolism Journal 2019;43(5):568-577
Mitochondrial function is crucial for the maintenance of cellular homeostasis under physiological and stress conditions. Thus, chronic exposure to environmental chemicals that affect mitochondrial function can have harmful effects on humans. We argue that the concept of hormesis should be revisited to explain the non-linear responses to mitochondrial toxins at a low-dose range and develop practical methods to protect humans from the negative effects of mitochondrial toxins. Of the most concern to humans are lipophilic chemical mixtures and heavy metals, owing to their physical properties. Even though these chemicals tend to demonstrate no safe level in humans, a non-linear dose-response has been also observed. Stress response activation, i.e., hormesis, can explain this non-linearity. Recently, hormesis has reemerged as a unifying concept because diverse stressors can induce similar stress responses. Besides potentially harmful environmental chemicals, healthy lifestyle interventions such as exercise, calorie restriction (especially glucose), cognitive stimulation, and phytochemical intake also activate stress responses. This conceptual link can lead to the development of practical methods that counterbalance the harm of mitochondrial toxins. Unlike chemical hormesis with its safety issues, the activation of stress responses via lifestyle modification can be safely used to combat the negative effects of mitochondrial toxins.
Dementia
;
Diabetes Mellitus, Type 2
;
Environmental Exposure
;
Environmental Pollutants
;
Homeostasis
;
Hormesis
;
Humans
;
Life Style
;
Metals, Heavy
;
Mitochondria
;
Nonlinear Dynamics
;
Organic Chemicals