The purpose of this study was to investigate the effect of dietary sea-tangle extracts on blood glucose levels, serum lipid levels, thiobarbituric acid reactive substance (TBARS) and glutathione enzymes in diabetic rats treated with streptozotocin (STZ) Four groups of rats (Sprague-Dawley male rats, 180 - 200g) were consisted of normal rats fed control diet (C), diabetic rats fed control diet (CD), normal rats fed sea-tangl extracts diet (E), and diabetic rats fed sea-tangle extracts diet (ED). Diabetes was induced by single injection of streptozotocin (60 mg/kg B.W.). After 7 weeks, rats were sacrificed, serum glucose, serum total cholesterol, triglyceride levels and glutathione enzymes were measured. Urine was significantly higher in CD and ED groups than those of others (p < 0.05). Levels of amylase, calcium, uric acid, hemoglobin, cholesterol and low density lipoprotein (LDL)-cholesterol were different among four groups. But high density cholesterol (HDL)-cholesterol of ED group was significantly higher (p < 0.05) than other groups (C and E group) And the weekly change of serum glucose was decreased in the 3th,4th and 5th weeks. But serum triglyceride (TG) of diabetic rats fed sea-tangle extracts diet (ED) was lower than diabetic rats fed control diet (CD). Activity of hepatic microsomal G6Pase was significantly increased CD and ED groups higher than C and E group, but kidney was decreased ED group. Hepateic glutathione S-transferase (GST) of CD and ED group were significantly lower than C and E group (p<0.05), glutathione peroxidase (GPX) of E and ED group were significantly higher than C and CD group (p<0.05), glutathione reductase (GR) activities of ED group was significantly lower than other groups, malondialdehyde (MDA) of ED was lower than E and CD group, but kidney was increased significant in ED group compared to liver. These results suggested that dietary sea-tangle extracts reduce .hepatic disorders such as oxidant than kidney. In conclusion, dietary sea-tangle extracts groups reduced blood TG and hepatic MDA levels in STZ-induced diabetic rats.
Amylases ; Animals ; Blood Glucose ; Calcium ; Cholesterol ; Diet ; Glucose ; Glutathione ; Glutathione Peroxidase ; Glutathione Reductase ; Glutathione Transferase ; Humans ; Kidney ; Lipoproteins ; Liver ; Male ; Malondialdehyde ; Rats* ; Streptozocin ; Triglycerides ; Uric Acid

Purpose: This study aimed to assess dementia awareness and educational needs among elderly care facility workers and to explore their experiences in caring for older adults with dementia through a mixed-methods approach. Methods: From May 1 to 31, 2023, 311 workers from dementia-related institutions in S City participated in a survey. Following the quantitative phase, 10 individuals participated in focus group interviews to further explore their experiences and needs. Quantitative data were analyzed using SPSS/WIN 25.0, and thematic analysis was applied to qualitative data. Results: The average dementia awareness score was 0.83±0.13 (out of 12), with the highest correct response rate (93%) in the "prevention and t reatment" category. The most requested education topics included managing "agitation and aggression" and improving "communication" skills. Qualitative analysis revealed two main themes with five subthemes, capturing staff experiences in dementia care and their perceived educational needs. Conclusion The findings highlight a strong demand for practical, structured training programs tailored to address behavioral management and communication challenges faced by facility staff.

Purpose: This study aimed to assess dementia awareness and educational needs among elderly care facility workers and to explore their experiences in caring for older adults with dementia through a mixed-methods approach. Methods: From May 1 to 31, 2023, 311 workers from dementia-related institutions in S City participated in a survey. Following the quantitative phase, 10 individuals participated in focus group interviews to further explore their experiences and needs. Quantitative data were analyzed using SPSS/WIN 25.0, and thematic analysis was applied to qualitative data. Results: The average dementia awareness score was 0.83±0.13 (out of 12), with the highest correct response rate (93%) in the "prevention and t reatment" category. The most requested education topics included managing "agitation and aggression" and improving "communication" skills. Qualitative analysis revealed two main themes with five subthemes, capturing staff experiences in dementia care and their perceived educational needs. Conclusion The findings highlight a strong demand for practical, structured training programs tailored to address behavioral management and communication challenges faced by facility staff.

Purpose: This study aimed to assess dementia awareness and educational needs among elderly care facility workers and to explore their experiences in caring for older adults with dementia through a mixed-methods approach. Methods: From May 1 to 31, 2023, 311 workers from dementia-related institutions in S City participated in a survey. Following the quantitative phase, 10 individuals participated in focus group interviews to further explore their experiences and needs. Quantitative data were analyzed using SPSS/WIN 25.0, and thematic analysis was applied to qualitative data. Results: The average dementia awareness score was 0.83±0.13 (out of 12), with the highest correct response rate (93%) in the "prevention and t reatment" category. The most requested education topics included managing "agitation and aggression" and improving "communication" skills. Qualitative analysis revealed two main themes with five subthemes, capturing staff experiences in dementia care and their perceived educational needs. Conclusion The findings highlight a strong demand for practical, structured training programs tailored to address behavioral management and communication challenges faced by facility staff.

Purpose: This study aimed to assess dementia awareness and educational needs among elderly care facility workers and to explore their experiences in caring for older adults with dementia through a mixed-methods approach. Methods: From May 1 to 31, 2023, 311 workers from dementia-related institutions in S City participated in a survey. Following the quantitative phase, 10 individuals participated in focus group interviews to further explore their experiences and needs. Quantitative data were analyzed using SPSS/WIN 25.0, and thematic analysis was applied to qualitative data. Results: The average dementia awareness score was 0.83±0.13 (out of 12), with the highest correct response rate (93%) in the "prevention and t reatment" category. The most requested education topics included managing "agitation and aggression" and improving "communication" skills. Qualitative analysis revealed two main themes with five subthemes, capturing staff experiences in dementia care and their perceived educational needs. Conclusion The findings highlight a strong demand for practical, structured training programs tailored to address behavioral management and communication challenges faced by facility staff.

Purpose: This study aimed to assess dementia awareness and educational needs among elderly care facility workers and to explore their experiences in caring for older adults with dementia through a mixed-methods approach. Methods: From May 1 to 31, 2023, 311 workers from dementia-related institutions in S City participated in a survey. Following the quantitative phase, 10 individuals participated in focus group interviews to further explore their experiences and needs. Quantitative data were analyzed using SPSS/WIN 25.0, and thematic analysis was applied to qualitative data. Results: The average dementia awareness score was 0.83±0.13 (out of 12), with the highest correct response rate (93%) in the "prevention and t reatment" category. The most requested education topics included managing "agitation and aggression" and improving "communication" skills. Qualitative analysis revealed two main themes with five subthemes, capturing staff experiences in dementia care and their perceived educational needs. Conclusion The findings highlight a strong demand for practical, structured training programs tailored to address behavioral management and communication challenges faced by facility staff.

PURPOSE: The purpose of this study is to evaluate the knowledge and attitudes of oncology ward nurses toward cancer pain management and to find ways to improve the educational program for nurses. METHOD: A total of 209 nurses working at the oncology ward of three hospitals in Seoul and a Gyenggi Province. The survey instrument used was the 32-item scale for evaluating nurses knowledge and attitudes originally developed by McCaffery and Ferrell'(1990), that was by Kim'(1997). RESULTS: In terms of the nurses knowledge of pain management, the result showed that the nurses scored an average of 67.8 out of 100 for phamacokinetics of opioids, 84.8 for classification of analgesics, 60.1 for pain assessment, and 70.7 for drug administration. 18.2% of the nurses hesitate to inject the narcotic agent because of concerns regarding the drug's potential side effects. there was significant difference in the knowledge of pain management according to the general characteristics of pain in terms of the nurses age(p=.001), position (p=.016), years of experiences(p=.002), experience of cancer pain education(p=.001). CONCLUSION: The also showed that nurses working at cancer ward lack knowledge. It is important to provide intensive education to nurses about cancer pain management.
Analgesics ; Analgesics, Opioid ; Classification ; Education ; Pain Management* ; Pain Measurement ; Seoul

PURPOSE: The purpose of this study is to evaluate the knowledge and attitudes of oncology ward nurses toward cancer pain management and to find ways to improve the educational program for nurses. METHOD: A total of 209 nurses working at the oncology ward of three hospitals in Seoul and a Gyenggi Province. The survey instrument used was the 32-item scale for evaluating nurses knowledge and attitudes originally developed by McCaffery and Ferrell'(1990), that was by Kim'(1997). RESULTS: In terms of the nurses knowledge of pain management, the result showed that the nurses scored an average of 67.8 out of 100 for phamacokinetics of opioids, 84.8 for classification of analgesics, 60.1 for pain assessment, and 70.7 for drug administration. 18.2% of the nurses hesitate to inject the narcotic agent because of concerns regarding the drug's potential side effects. there was significant difference in the knowledge of pain management according to the general characteristics of pain in terms of the nurses age(p=.001), position (p=.016), years of experiences(p=.002), experience of cancer pain education(p=.001). CONCLUSION: The also showed that nurses working at cancer ward lack knowledge. It is important to provide intensive education to nurses about cancer pain management.
Analgesics ; Analgesics, Opioid ; Classification ; Education ; Pain Management* ; Pain Measurement ; Seoul

This study examined the anti-diabetic effect of onion (Allium cepa. Linn) in the streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were divided into normal rats fed control diet or supplemented with onion powder (7% w/w) and diabetic rats fed control diet or supplemented with onion powder. Diabetes was induced by a single injection of STZ (60 mg/kg, ip) in citrate buffer. The animals were fed each of the experimental diet for 5 weeks. Blood glucose levels of rats supplemented with onion were lower than those of rats fed control diet in the diabetic rats. Onion also decreased the total serum lipid, triglyceride, and atherogenic index and increased HDL-cholesterol/total cholesterol ratio in the diabetic rats. Glutathione peroxidase, glutathione reductase and glutathione S-transferase activities were high in the diabetic rats compared to normal rats and reverted to near-control values by onion. These results indicate that onion decreased blood glucose, serum lipid levels and reduced renal oxidative stress in STZ-induced diabetic rats and this effect might exert the anti-diabetic effect of onion.
Animals ; Blood Glucose ; Cholesterol ; Citric Acid ; Diet ; Glutathione Peroxidase ; Glutathione Reductase ; Glutathione Transferase ; Humans ; Male ; Onions ; Oxidative Stress ; Rats ; Rats, Sprague-Dawley ; Streptozocin

The demand for rapid and broad clinical toxicology screens is on the rise. Recently, a new rapid toxicology screening test, the Triage TOX Drug Screen (Alere Inc., USA), which can simultaneously detect 11 drugs of abuse and therapeutic drugs with an instrument-read cartridge, was developed. In the present study, we evaluated the efficacy of this new on-site immunoassay using 105 urine specimens; the results were compared with those obtained by using ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-TMS). Precision was evaluated according to the CLSI EP12-A2 for analyte concentrations near the cutoff, including C₅₀ and±30% of C₅₀, for each drug using standard materials. The C₅₀ specimens yielded 35–65% positive results and the ±30% concentration range of all evaluated drugs encompassed the C₅–C₉₅ interval. The overall percent agreement of the Triage TOX Drug Screen was 92.4–100% compared with UPLC-TMS; however, the Triage TOX Drug Screen results showed some discordant cases including acetaminophen, amphetamine, benzodiazepine, opiates, and tricyclic antidepressants. The overall performance of the Triage TOX Drug Screen assay was comparable to that of UPLC-TMS for screening of drug intoxication in hospitals. This assay could constitute a useful screening method for drugs of abuse and therapeutic drugs in urine.
Acetaminophen ; Amphetamine ; Antidepressive Agents, Tricyclic ; Benzodiazepines ; Chromatography, Liquid ; Immunoassay ; Mass Screening ; Methods ; Street Drugs* ; Tandem Mass Spectrometry ; Toxicology ; Triage*