1.The Comparative Study of Efficacy in using Midazolam and Propofol in the case of Radiology Examinations for Emergency Patients.
Sin JU ; Nam Soo CHO ; Soo Hyeong CHO ; Meung Ryong KIM ; Chul Gab LEE
Journal of the Korean Society of Emergency Medicine 2002;13(2):163-168
PURPOSE: This study was performed to evaluate the usefulness of propofol in radiology studies by comparing propofol sedation with midazolam for patients who do not comply with their doctor's requests and need an injection of a sedative to be treated for a safe and quick recovery without complications. METHODS: Among adult patients who were admitted and checked using CT and MRI in our emergency medical center from February 2001 to August 2001, the patients who required sedation because of the lack of cooperation with ER doctors were studied. Of 49 patients, 23 patients (Group M) were injected with midazolam, and 26 patients (Group P) were injected with propofol. RESULTS: In both groups, the systolic BP and the diastolic BP decreased, but group P's BP decreased more than group M's (p<0.05). In group M, the decrease of SPO2 w a s statistically significant, but neither of the groups required emergency care. Although, Group M didn't require emergency care for SpO2, they did require more emergency care for apnea than Group P did. Group P's time required for an examination to be performed was shorter than group M's. Group P's duration for occurrence of movement was shorter than Group M's, but this difference was not statistically significant. Regardless of which sedative was used, there was no difference in the satisfaction of the radiology technician with regards to group M and group P. CONCLUSION: When the patients were injected with a lowdosage of propofol, they showed effects similar to those observed in patients in injected with midazolam, and there were no complications that required emergency care. The usage of propofol is thought to be a good choice, except for contraindications, for short-time radiology examinations.
Adult
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Apnea
;
Emergencies*
;
Emergency Medical Services
;
Humans
;
Magnetic Resonance Imaging
;
Midazolam*
;
Propofol*
2.Clinical analysis of mitral valvular disease.
Chang Soo KIM ; Gang Bae HUH ; Eon Sub JEONG ; Jong Hae JEONG ; Jae Sung LEE ; Sung Rae CHO ; Song Meung KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(4):382-389
No abstract available.
3.Clinical Studies of Metabolic Bone Disease of Prematurity.
Seung Yeon SUH ; Eun Kyung LEE ; Ran NAMGUNG ; Hae Jung JOO ; Min Soo PARK ; Kook In PARK ; Chul LEE ; Dong Gwan HAN ; Meung Jun KIM ; Jin Suk SUH
Journal of the Korean Pediatric Society 1995;38(2):159-169
PURPOSE: Preterm formula used in Korea, theoretically does not supply the recommended mineral intake for optimal bone metabolism in very low birth weight infants(Formula 500-700 mg Ca/L, 300~370mg P/L, and 440IU of vitamin D/L). The purpose of this study is to identify th e possible etiologic factors and clinical course of rickets in these infants. METHODS: We recently identified radiographic rickets or osteopenia in 16 VLBW infants over a 30-month period from January 1990, to July 1992. We performed a retrospective case analysis to evaluate the clinical features, nutritional status, biochemical and radiological findings o f metabolic disease in preterm infants. RESULTS: Mean gestational age and birth weight were 29+/-2.1wks, and 1172+/-245gm. All infants received parenteral nutrition and 11 infants needed assisted ventilation. Enteral feeding w as started at a mean age of 9.4+/-11.0d and mean total calorie intakes were 62+/-16.2kcal/kg /d in the first 2wks and 111+/-26.9kcal/kg/d at 2-4 wks of age. Oral Ca/P intakes were severely restricted during the first month of life, and they were about 20% of recommended intakes of Ca /P for VLBW infants. At diagnosis of active rickets, serum Ca was high in 19% and serum P wa s low in 69% of infants. Serum alkaline phosphatase was increased in 56% and serum 25-hydroxyvitamin D was low in 67%. Active rickets was diagnosed at mean age of 38+/-14.7 d; 12 infants had overt rickets(grade 2), including 3 infants with fractures(grade 3). Healing rickets was diagnosed on follow-up at mean age of 67.3+/-22.0 days. Thus, metabolic bone disease of VLB W infants was associated with low mineral intakes compared to recommended intakes, and signs of P deficiency occurred at about 2 wks of age and persisted to 8 wks of age; hypercalcemia occurred initially, and these biochemical abnormalities precede the radiological abnormalities about 2 or 3 weeks. CONCLUSIONS: Many factors are related to the development of metabolic hone disease of prematurity; one of the most important factor in our study was nutritional deficiency, especially m ineral(phosphorus) and vitamin D. In preterm VLBW infants whose adequate enteral feeding is restricted, mineral(calcium and phosphorus) and vitamin D supplementation would be needed t o reduce the development of metabolic bone disease in preterm infants.
Alkaline Phosphatase
;
Birth Weight
;
Bone Diseases, Metabolic*
;
Diagnosis
;
Enteral Nutrition
;
Follow-Up Studies
;
Gestational Age
;
Humans
;
Hypercalcemia
;
Infant
;
Infant, Newborn
;
Infant, Premature
;
Infant, Very Low Birth Weight
;
Korea
;
Malnutrition
;
Metabolic Diseases
;
Metabolism
;
Nutritional Status
;
Parenteral Nutrition
;
Retrospective Studies
;
Rickets
;
Ventilation
;
Vitamin D
;
Vitamins
4.Impact of the Junction Adhesion MoleculeA on Asthma
Min-Hyeok AN ; Pureun-Haneul LEE ; Seon-Muk CHOI ; DaYeon HWANG ; Jung-Hyun KIM ; Meung Chul PARK ; Shinhee PARK ; Ae-Rin BAEK ; An-Soo JANG
Yonsei Medical Journal 2023;64(6):375-383
Purpose:
Junctional adhesion molecule (JAM)-A is an immunoglobulin-like molecule that colocalizes with tight junctions (TJs) in the endothelium and epithelium. It is also found in blood leukocytes and platelets. The biological significance of JAM-A in asthma, as well as its clinical potential as a therapeutic target, are not well understood. The aim of this study was to elucidate the role of JAM-A in a mouse model of asthma, and to determine blood levels of JAM-A in asthmatic patients.
Materials and Methods:
Mice sensitized and challenged with ovalbumin (OVA) or saline were used to investigate the role of JAM-A in the pathogenesis of bronchial asthma. In addition, JAM-A levels were measured in the plasma of asthmatic patients and healthy controls. The relationships between JAM-A and clinical variables in patients with asthma were also examined.
Results:
Plasma JAM-A levels were higher in asthma patients (n=19) than in healthy controls (n=12). In asthma patients, the JAM-A levels correlated with forced expiratory volume in 1 second (FEV1%), FEV1/forced vital capacity (FVC), and the blood lymphocyte proportion. JAM-A, phospho-JNK, and phospho-ERK protein expressions in lung tissue were significantly higher in OVA/OVA mice than in control mice. In human bronchial epithelial cells treated with house dust mite extracts for 4 h, 8 h, and 24 h, the JAMA, phospho-JNK, and phospho-ERK expressions were increased, as shown by Western blotting, while the transepithelial electrical resistance was reduced.
Conclusion
These results suggest that JAM-A is involved in the pathogenesis of asthma, and may be a marker for asthma.
5.Clinical Charateristics of Pyrethroids Poisoning.
Kwan Seok PARK ; Moon Soo KANG ; Cheol Woo LEE ; Jong Yong OH ; Ki Won JEON ; Kyu Ho PARK ; Bong Min KO ; Hung Sok OH ; In Seop JUNG ; Meung Soo KIM ; Sung Han BAE ; Dong Ho YANG ; Sae Yong HONG
Korean Journal of Medicine 1998;55(5):926-933
OBJECTIVES: Pyrethroids are commonly used pesticides, and acute human poisoning by these insecticides is common in Korea. It has a high affinity to the sodium channel on cell membranes causing blockage, which results in neurotoxicity, hyperexcitation, and death. The purpose of this study was to analyze the clinical characteristics of acute pyrethroid poisoning. METHODS: To evaluate the clinical characteristics (age, sex, causative agents, cause of ingestion, severity of poisoning and its clinical feature, prognosis, complication and results of the treatment), we analyzed the clinical reports of 30 patients with pyrethroid poisoning who were admitted to Soonchunhyang Chunan hospital from January 1992 to July 1997. RESULTS: 1) 18 out of 30 patients with pyrethroid poisoning were male and the largest age group was above 60 years old. 2) The most common cause of ingestion was suicide, in 24 cases (80%). 3) There were 7 classes of causative agents of poisoning and all of these were classified into 2 grades according to the degree of WHO toxicity. Fenvlaerate and cypermethrin were the most common agents. 4) The degree of severity was classified into three groups - mild, moderate and life -threatened. Of these groups, mild poisonig was the most common. There was no significant difference in the age, type of pyrethoid and interval between pyrethroid ingestion and arriving at the emergency room between the three groups. However, the amount of ingestion was significantly higher in the life-threatened group. 5) The most common symptom of the patients was vomiting, in 19 patients. The classification were of three types (5 type I, 11 type II and 1 intermediate type) according to clinical characteristics. 6) There is no specific antidote, therefore therapy is generally supportive. There were three deaths, and the cause of death was respiratory failure. 7) The most common complication was pneumonia, in 3 cases (10%), which occured in almost all patients in the life-threatened group. CONCLUSIONS: The most common age group of poisoing was over 60 years old, and suicide was the most common cause of ingestion. Treatment is supportive, and most causal exposures require only decontamination. There were three deaths, and the cause of death was respiratory failure in each case. The most common complication was pneumonia.
Cause of Death
;
Cell Membrane
;
Chungcheongnam-do
;
Classification
;
Decontamination
;
Eating
;
Emergency Service, Hospital
;
Humans
;
Insecticides
;
Korea
;
Male
;
Middle Aged
;
Pesticides
;
Pneumonia
;
Poisoning*
;
Prognosis
;
Pyrethrins*
;
Respiratory Insufficiency
;
Sodium Channels
;
Suicide
;
Vomiting
6.Correlation of beta-catenin and p53 Protein Expression with Clinico-pathologic Characteristics of Colorectal Cancer.
Kil Min MOON ; Young Jin PARK ; Han Seung KIM ; Seung Hae PARK ; Ji Il KIM ; Ki Hong KIM ; Byung Joo SONG ; Meung Soo LEE ; Chul Nam KIM ; Seok Hyo CHANG
Journal of the Korean Society of Coloproctology 2002;18(5):311-316
PURPOSE: Both the beta-catenin and p53 play a crucial role in the process of colon carcinogenesis. The expression of beta-catenin and/or p53 has been reported to be associated with pathologic features of tumor and prognosis of patients. In addition, several recent studies have suggested a close biological association between p53 expression and nuclear beta-catenin level. We analyzed the pathologic variables and p53 expression according to the intra-nuclear beta-catenin expression in colon cancer to make such assumptions more clear since they are still controversial issues. METHODS: The expressions of beta-catenin, p53 and Ki-67 protein in colon cancer were determined by immunohistochemical staining. The relationship between these protein expressions and tumor characteristics was statistically analyzed. RESULTS: The intra-nuclear beta-catenin accumulation was not associated with any of the pathological variables including lymph node metastasis and tumor differentiation, but it was correlated with higher level of Ki-67 proliferation index (P=0.006) and negative staining of p53 (P=0.015). Positive p53 staining was significantly associated with lymph node metastasis (P=0.006), lymphatic invasion (P=0.03) and venous invasion (P=0.02). CONCLUSION: These results support the suggestion that intra-nuclear accumulation of beta-catenin may regulate the p53 activity in colorectal cancer. In addition, positive staining of p53 may be used as a valuable prognostic indicator since it was strongly associated with lymph node metastasis, lymphatic and venous invasion.
beta Catenin*
;
Carcinogenesis
;
Colon
;
Colonic Neoplasms
;
Colorectal Neoplasms*
;
Humans
;
Lymph Nodes
;
Lymphatic Metastasis
;
Negative Staining
;
Neoplasm Metastasis
;
Prognosis