Methamphetamine （MAMP） is a kind of amphetamine-type stimulants （ATS） which contains one chiral carbon atom in its structure. Therefore a pair of enantiomers, S-（+）-MAMP and R-（-）-MAMP exist. R type and S type methamphetamines possess similar physicochemical properties, but has largely different pharmacological and toxic effects. S-（+）-MAMP is the main component of addictive drug "Ice" at present, seriously affecting human health and public safety. The separation analysis and mechanism of toxic effects discussions on MAMP are the current research focuses. This paper reviews the research progress of separation analysis methods and toxic effects of methamphetamine enantiomers to provide reference for forensic study and forensic practice.
Central Nervous System Stimulants ; Humans ; Methamphetamine/chemistry* ; Stereoisomerism ; Substance Abuse Detection

OBJECTIVE: To develop a specific CZE method for the determination of methamphetamine in whole blood after solid phase extraction. METHODS: With the doxapram as internal standard, Oasis column was used to extract drugs from whole blood and the sample was analysized by CZE. RESULTS: The method showed excellent linearity and the linear correlation coefficient was 0.994. The relative standard deviation for between-day and within-day were 5.31% and 2.22%, respectively. CONCLUSION The method is effective, simple, reliable and has been used in the determination of methamphetamine in whole blood.
Doxapram/chemistry* ; Electrophoresis, Capillary/methods* ; Forensic Medicine ; Gas Chromatography-Mass Spectrometry ; Humans ; Methamphetamine/poisoning* ; Reproducibility of Results ; Sensitivity and Specificity ; Solid Phase Extraction ; Solvents/chemistry*