1.Increase of Metabolic Syndrome Score is an Independent Determinant of Increasing Pulse Pressure.
Jae Youn MOON ; Sungha PARK ; Chul Min AHN ; Jung Rae CHO ; Chan Mi PARK ; Young Guk KO ; Donghoon CHOI ; Myung Ho JEONG ; Yangsoo JANG ; Namsik CHUNG
Yonsei Medical Journal 2008;49(1):63-70
PURPOSE: The objective of this study was to determine whether the progressive increase of metabolic syndrome (MetS) score, the number of components of MetS, is correlated significantly with increasing pulse pressure (PP). MATERIALS AND METHODS: 4,034 subjects were enrolled from the Cardiovascular Genome Center of Yonsei University (M:F=2344:1690, 55.2 +/- 10.5). Most of the study population were recruited from hypertension clinics, controlled with medications according to JNC7 guidelines. The Asian modified criteria of MetS were applied and MetS score was estimated. The HOMA index for insulin resistance, cholesterol profiles, and anthropometric measurements were assessed. RESULTS: Among 4034 participants, 1690 (41.9%) were classified as MetS. Progressive increase in PP was demonstrated for increasing components of the MetS score. Multiple linear regression analysis with PP as the dependent variable showed that age (beta=0.311, p < 0.001), MetS score (beta=0.226, p < 0.001), male gender (beta=-0.093, p < 0.001) and HOMA index IR (beta=0.033, p=0.03) are significantly associated with PP (R(2)=0.207, p < 0.001). CONCLUSION: The present results from this study demonstrate that increasing MetS score is an independent determinant of increasing PP. The results also demonstrate the independent role of MetS in increasing arterial stiffness and PP.
Adult
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Age Distribution
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Aged
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Blood Pressure
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Female
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Humans
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Male
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Metabolic Syndrome X/*epidemiology/physiopathology
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Middle Aged
2.Association of Visceral Fat and Risk Factors for Metabolic Syndrome in Children and Adolescents.
Jeong Hyeon KWON ; Han Yun JANG ; Min Jin OH ; Jun Seung RHO ; Ju Hye JUNG ; Keun Sang YUM ; Ji Whan HAN
Yonsei Medical Journal 2011;52(1):39-44
PURPOSE: Visceral fat (VF) is closely associated with many metabolic risk factors and is also known to be a strong predictive factor for severe metabolic complications in adults. But there are only a few studies concerning the association of VF and risk factors for metabolic syndrome (MS) in children and adolescents. In our study, we emphasized the association of VF [measured by VF computed tomography (VFCT)] and risk factors for metabolic syndrome in children and adolescents. MATERIALS AND METHODS: The subjects were outpatients aged 6 to 18 years who underwent VFCT in the family medicine of The Catholic University of Korea from January 2005 to August 2009. There were 82 patients in total (42 children, 40 adolescents). Height, weight, blood pressure (BP), blood tests, body composition analysis and VF were measured. The three groups were also classified by metabolic score. RESULTS: In children, only high density lipoprotein cholesterol (HDL-C) showed a statistically significant difference, while in adolescents, triglyceride, HDL-C, BP, body mass index (BMI), waist circumference (WC) and VFA showed statistically significant differences. In terms of VFA, fasting glucose, BP, BMI, basal metabolic rate (BMR) and WC showed statistically significant differences. BMI showed a statistically significant difference in terms of BP, BMR, WC, VFA and HDL-C. CONCLUSION: There is a need to acknowledge the statistically significant associations of VF and risk factors for MS in children and adolescents. Screening tests for BP, cholesterol, fasting glucose and WC should be given in clinics for children and adolescents so that MS can be detected and its risk factors treated early.
Adolescent
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Body Mass Index
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Child
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Female
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Humans
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Intra-Abdominal Fat/*physiology
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Male
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Metabolic Syndrome X/*epidemiology/metabolism/physiopathology
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Risk Factors
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Waist Circumference/physiology
3.The Distribution of Intraocular Pressure and Its Association With Metabolic Syndrome in a Community.
Sang shin PARK ; Eun Hee LEE ; Ganchimeg JARGAL ; Domyung PAEK ; Sung Il CHO
Journal of Preventive Medicine and Public Health 2010;43(2):125-130
OBJECTIVES: The current study was performed to assess the distribution of intraocular pressure (IOP) and its association with metabolic syndrome (MS) in a community. METHODS: We measured IOP and MS components from 446 adults, age 20 or more years old, who reside in a community in Kyunggi Province, South Korea. We compared the level of IOP according to the number of metabolic abnormalities and between normal and abnormal metabolic components. Linear regression analyses were used to determine the relationship between IOP and metabolic components. RESULTS: No significant difference in IOP (mean +/- SE) was found between men (12.24 +/- 2.42) and women (12.55 +/- 2.41 mmHg, p > 0.1), while IOP of men tended to decrease as age increased (p for trend < 0.01). After adjusting for age, IOP of subjects with abdominal obesity in men and high blood pressure in women were significantly higher than those without abdominal obesity or high blood pressure (p < 0.05). Female subjects with MS showed significantly higher IOP than those without MS. Participants with more metabolic disturbances tended to have a greater IOP elevation with a linear trend after adjusting for age and sex. In the univariate regression analysis, age and waist circumference were significantly associated with IOP in men, but systolic and diastolic blood pressure were associated with IOP in women. In final multiple regression model, age, systolic blood pressure, and triglyceride were associated with IOP in women, and age in men. CONCLUSIONS: These findings suggest that MS and its components may be important determinants of elevated IOP.
Adult
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Age Factors
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Body Mass Index
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Female
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Health Behavior
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Humans
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Hypertension/physiopathology
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Insulin Resistance/physiology
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*Intraocular Pressure
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Linear Models
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Lipids/blood
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Male
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Metabolic Syndrome X/*complications/epidemiology/physiopathology
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Middle Aged
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Republic of Korea/epidemiology
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Sex Factors
4.Comparison of the Metabolic Syndrome Risk Factor Prevalence Forty and Fifty Something Women.
Journal of Korean Academy of Nursing 2007;37(4):453-458
PURPOSE: The purpose of this study was to compare metabolic syndrome (MS) risk factor prevalence by obesity and age in middle-aged women. METHOD: Two hundred and fifty-one subjects were recruited from the health promotion center of a tertiary care hospital in an urban city. MS was defined by the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults(Adult Treatment Panel III)(ATPIII), and obesity was determined by body mass index(BMI)> or = 25kg/m2. RESULTS: The mean blood pressure, fasting glucose, total cholesterol, and triglyceride were significantly higher in the obese group than in the non-obese group. The prevalence of MS, hypertension, and impaired fasting glucose were significantly higher in the obese group than in the non-obese group. In the forties, blood pressure was significantly higher in the obese group than in the non-obese group. In the fifties, body fat, systolic blood pressure, fasting glucose, total cholesterol, and triglyceride were significantly higher in the obese group than in the non-obese group. CONCLUSIONS: These results show that the nurse should focus on the obese fifty year old female patients for improvement of the MS risk factors.
Women's Health
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Adult
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Blood Pressure
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Body Fat Distribution
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Body Mass Index
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Cholesterol/blood
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Female
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Health Surveys
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Humans
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Metabolic Syndrome X/*epidemiology/etiology
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Middle Aged
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Models, Nursing
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Obesity/*complications/epidemiology/physiopathology
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Prevalence
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Risk Factors
5.A Prospective Study of Epicardial Adipose Tissue and Incident Metabolic Syndrome: The ARIRANG Study.
Ji Hyun LEE ; Jang Young KIM ; Kyung Min KIM ; Jun Won LEE ; Young Jin YOUN ; Min Soo AHN ; Byung Su YOO ; Seung Hwan LEE ; Junghan YOON ; Kyung Hoon CHOE ; Song Vogue AHN ; Sang Baek KOH ; Jong Ku PARK ; Sung Gyun AHN
Journal of Korean Medical Science 2013;28(12):1762-1767
Increased epicardial adipose tissue (EAT) may be closely associated with the development of metabolic abnormalities. We investigated whether EAT predicts the incident metabolic syndrome in a community-based, middle-aged population. The study subjects were comprised of 354 adults (134 men and 220 women) aged 40 to 70 yr without metabolic syndrome. Baseline EAT thickness, measured by echocardiography, was compared between subjects who developed new-onset metabolic syndrome at follow-up survey and those who did not. After an average of 2.2 yr of follow-up, 32 men (23.9%) and 37 women (16.8%) developed metabolic syndrome. Median EAT thickness at baseline was significantly higher in male subjects who developed metabolic syndrome than those who did not (1.52 mm vs 2.37 mm, P<0.001). The highest quartile of EAT thickness (> or =2.55 mm) was associated with increased risk of progression to metabolic syndrome (Odds ratio [OR], 3.09; 95% confidence interval [CI], 1.11-8.66) after adjustment for age, smoking, alcohol intake, regular exercise, total energy intake, high sensitive C-reactive protein and homeostasis model assessment of insulin resistance in men. A significant association of EAT with incident metabolic syndrome was not seen in women (OR, 1.25; 95% CI, 0.54-2.90). In conclusion, increased EAT thickness is an independent predictor for incident metabolic syndrome in men.
Adipose Tissue/*physiopathology
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Adult
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Aged
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Blood Pressure
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Body Mass Index
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C-Reactive Protein/analysis
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Echocardiography
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Female
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Follow-Up Studies
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Humans
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Incidence
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Male
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Metabolic Syndrome X/*epidemiology
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Middle Aged
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Odds Ratio
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Pericardium/*pathology/physiopathology
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Prospective Studies
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Risk Factors
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Sex Factors
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Waist Circumference
6.Impact of the Metabolic Syndrome on the Clinical Outcome of Patients with Acute ST-Elevation Myocardial Infarction.
Min Goo LEE ; Myung Ho JEONG ; Youngkeun AHN ; Shung Chull CHAE ; Seung Ho HUR ; Taek Jong HONG ; Young Jo KIM ; In Whan SEONG ; Jei Keon CHAE ; Jay Young RHEW ; In Ho CHAE ; Myeong Chan CHO ; Jang Ho BAE ; Seung Woon RHA ; Chong Jin KIM ; Donghoon CHOI ; Yang Soo JANG ; Junghan YOON ; Wook Sung CHUNG ; Jeong Gwan CHO ; Ki Bae SEUNG ; Seung Jung PARK
Journal of Korean Medical Science 2010;25(10):1456-1461
We sought to determine the prevalence of metabolic syndrome (MS) in patients with acute myocardial infarction and its effect on clinical outcomes. Employing data from the Korea Acute Myocardial Infarction Registry, a total of 1,990 patients suffered from acute ST-elevation myocardial infarction (STEMI) between November 2005 and December 2006 were categorized according to the National Cholesterol Education Program-Adult Treatment Panel III criteria of MS. Primary study outcomes included major adverse cardiac events (MACE) during one-year follow-up. Patients were grouped based on existence of MS: group I: MS (n=1,182, 777 men, 62.8+/-12.3 yr); group II: Non-MS (n=808, 675 men, 64.2+/-13.1 yr). Group I showed lower left ventricular ejection fraction (LVEF) (P=0.005). There were no differences between two groups in the coronary angiographic findings except for multivessel involvement (P=0.01). The incidence of in-hospital death was higher in group I than in group II (P=0.047), but the rates of composite MACE during one-year clinical follow-up showed no significant differences. Multivariate analysis showed that low LVEF, old age, MS, low high density lipoprotein cholesterol and multivessel involvement were associated with high in-hospital death rate. In conclusion, MS is an important predictor for in-hospital death in patients with STEMI.
Acute Disease
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Age Factors
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Aged
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C-Reactive Protein/analysis
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Cholesterol, LDL/blood
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Coronary Angiography
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Female
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Humans
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Male
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Metabolic Syndrome X/*complications/epidemiology
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Middle Aged
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Multivariate Analysis
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Myocardial Infarction/*complications/mortality/therapy
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Predictive Value of Tests
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Prognosis
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Treatment Outcome
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Ventricular Dysfunction, Left/complications/physiopathology