Background: Metabolic syndrome is characterized by a group of metabolic risk factors in one person but not a real disease. For this reason, metabolic syndrome is underestimated by clinicians and individuals. Metabolic syndrome that was not detected and treated timely can cause serious diseases. Objectives: 1) To investigate the abnormal blood biochemical parameters related to metabolic syndrome. 2) To determine the abnormal ratio of these parameters. 3) To screen the metabolic syndrome among the staffs of Ha Noi Medical University. Subjects and method: 229 staffs underwent laboratory tests to diagnose for the metabolic syndrome. Abnormal blood biochemical parameters were defined as follows: Fasting blood glucose level increased 6.1mmol/l or more. Triglycerides level is 2.3mmol/l or more, HDL-cholesterol decreased to less than 1.03mmol/l for men and less than 1.24mmol/l for women. Total cholesterol level is 5.2mmol/l or more. CT to HDL-C ratio is more than 3.63 and LDL cholesterol level is 3.5mmol/l or more. Results. Rate of subjects with glucose intolerance or blood fasting glucose higher than 6.1mmol/L is 20.09%. Rate of subjects with dyslipidemia is 61.14%. Average levels of blood glucose, triglycerides and cholesterol increase with age. Number of staffs of Ha Noi Medical University have metabolic syndrome in 2007 are 32 persons (14%). M/F rate is equal and most common in persons over 45 years of age. Conclusion:There are significant number of staffs at the Ha Noi Medical University that had abnormal blood glucose and cholesterol levels related to metabolic syndrome.
Metabolic syndrome ; blood biochemical parameters.

No abstract available.
Female ; Humans ; Metabolic Syndrome X/*blood ; Thyrotropin/*blood

No abstract available.
Antioxidants/*metabolism ; Female ; Humans ; Male ; Metabolic Syndrome X/*blood

Objective: This study aims to assess the dose-response relationship between serum ferritin (SF) and metabolic syndrome (MetS) in the two sexes. Methods: We searched for articles on PubMed, the Cochrane Library, EMBASE, and the Web of Science databases that were published from 1950 to 2020. The summary odds ratio ( Results: This study included 14 studies and 74,710 samples. The results of the classical meta-analysis showed that SF was positively associated with MetS ( Conclusions Our study shows that SF is significantly and positively associated with MetS, and the risk in the male population is higher than that in the female population. This finding also supports the recommendation of using SF as an early warning marker of MetS.
Biomarkers/blood* ; Female ; Ferritins/blood* ; Humans ; Male ; Metabolic Syndrome/epidemiology* ; Risk Factors ; Sex Characteristics

OBJECTIVETo compare the significance of the application in Jiangsu population using the diagnostic criteria for metabolic syndrome(MS) proposed by the IDF in 2005, ATP III in 2005 and CDS in 2004.

METHODSBased on the populations in Jiangsu province from a project of Multiple Metabolic Disorders and MS, the study was conducted including 5888 cases, with data of plasma glucose, lipid profile, blood pressure, serum insulin etc. MS was diagnosed and compared according to these three definitions respectively.

RESULTSThe age-adjusted MS prevalence rates were 17.48%, 21.95% and 9.59% according to the IDF(2005), ATP III (2005) and CDS (2004) respectively. The agreement in the diagnosis of MS using ATP III (2005) and CDS(2004) definitions was 85.11%, and the agreement in the diagnosis of MS using IDF(2005) and CDS definitions was 87.35%. The agreement in the diagnosis of MS using IDF (2005) and ATP III (2005) definitions was 95.14%. The MS subjects diagnosed by the ATP III (2005) was 1.26 higher than subjects diagnosed by the IDF(2005) definition. The ratios of prevalence rates of high waist circumference(WC), MS_IDF (2005) and MS_ATP III (2005) was 2.17, 1.99 and 1.54 in sex ratio (woman to man).

CONCLUSIONThe agreement in the diagnosis of MS using the IDF(2005) and ATP III (2005) definition was higher than using CDS(2004) and other two definitions. For diagnosing MS, the cut off of WC in IDF(2005) and ATP III (2005) seemed not appropriate and the diagnostic criteria used for ATP III (2005) (waist circumference of man 85 cm, woman 80 cm) could identify more MS.

Blood Glucose ; Blood Pressure ; China ; Humans ; Insulin ; blood ; Lipids ; blood ; Metabolic Syndrome ; diagnosis ; Reference Values ; Waist Circumference

OBJECTIVETo explore the relationship between serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and metabolic syndrome (MS).

METHODSA total of 1323 Beijing residents (559 male) were investigated. MS was defined by the modified 2004 Chinese Diabetes Society criteria and 439 cases were diagnosed as MS according to this criteria. Multivariate logistic regression analysis was used to estimate the odds ratios (OR) of MS. Multiple linear regression analysis was performed to analyze the association between NT-proBNP and characteristic variables.

RESULTSNT-proBNP was significantly lower in MS group compared to non-MS group [32.51 (29.17, 36.14) ng/L vs.38.55 (35.73, 41.50) ng/L, P = 0.012] after adjusted for age and gender. NT-proBNP level decreased with the presence of MS components (from 0 to 4 or 5) (45.92, 37.24, 35.40, 31.55 and 33.65 ng/L respectively, P = 0.043 for linear trend). Among the components, groups with larger waist circumference, higher fasting glucose and triglycerides were associated with lower NT-proBNP level. After adjustment for potential confounders, compared with the lowest NT-proBNP quartile, the adjusted odds ratio of the second, third and fourth quartile for having MS were 0.782 (95%CI: 0.544 - 1.122, P > 0.05), 0.709 (95%CI: 0.489 - 1.028, P > 0.05), 0.604 (95%CI: 0.405 - 0.900, P < 0.05), respectively. Multiple linear regression analysis showed that female gender (β = 0.248, P < 0.001), age (β = 0.167, P < 0.001), systolic blood pressure (β = 0.154, P < 0.001) were positively related to NT-proBNP level while waist circumference (β = -0.082, P = 0.004), diastolic blood pressure (β = -0.085, P = 0.015), triglycerides (β = -0.101, P < 0.001), total cholesterol (β = -0.078, P = 0.004), eGFR (β = -0.150, P < 0.001) were negatively correlated to NT-proBNP level.

CONCLUSIONIn this cohort, higher serum NT-proBNP concentration is associated with lower incidence of metabolic syndrome.

Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Humans ; Male ; Metabolic Syndrome ; blood ; Natriuretic Peptide, Brain ; blood ; Peptide Fragments ; blood

OBJECTIVETo study the relationship between various metabolic syndrome (MS) components in children and adolescents and to explore its potential pathophysiological mechanism.

METHODSA total of 1 550 children and adolescents aged 7-14 years from the Xiaoshan District of Hangzhou, China were enrolled in March 2010. The anthropometric parameters such as height, weight, waist circumference (WC), and hip circumference, as well as blood pressure, were measured; after adjustment for age and sex, body mass index z score (BMI-z), waist circumference z score (WC-z), waist-to-hip ratio (WHp), and waist-to-height ratio (WHt) were calculated. Fasting blood samples were collected for determination of fasting plasma glucose (FPG), total cholesterol (CHOL), triglyceride (TG), high-density lipoproteins (HDL), and low-density lipoproteins (LDL). Principal component analysis was used for extraction of factors.

RESULTSPrincipal component analysis revealed 5 uncorrelated factors that cumulatively explained 77.76% of the observed variance. Adiposity factor, which accounted for 23.56% of the variance, was the primary factor; it consisted of 3 variables, i.e., WC-z, WHt, and BMI-z, in which WC-z had the highest loading. The remaining factors identified were blood lipid factor 1 (TG, CHOL, and LDL), blood pressure factor, blood lipid factor 2 (TG and HDL), and blood glucose and WHp factor (FPG and WHp).

CONCLUSIONSMore than one pathophysiological mechanism could account for the development of MS in children and adolescents. Obesity, especially central obesity, is the most important factor in the development of MS. Dyslipidemia may not fully explain insulin resistance; they may work together in MS.

Adolescent ; Blood Pressure ; Child ; Female ; Humans ; Lipids ; blood ; Male ; Metabolic Syndrome ; blood ; etiology ; Principal Component Analysis ; Waist-Hip Ratio

PURPOSE: Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasis and lipid metabolism. Since serum FGF21 level has been implicated as a potential marker for the early identification of metabolic syndrome (MetS), we investigated the association between serum FGF21 level and the development of MetS in a population-based prospective study. MATERIALS AND METHODS: We conducted a prospective study of 221 randomly sampled adults without MetS from a general population-based cohort study who were examined from 2005–2008 (baseline) and from 2008–2011 (follow-up). Baseline serum FGF21 levels were analyzed using enzyme-linked immunosorbent assay. RESULTS: During the average 2.8-year follow-up period, 82 participants (36.6%) developed new-onset MetS. Serum FGF21 levels were significantly higher in patients with new-onset MetS than in those without MetS (209.56±226.80 vs. 110.09±81.10, p < 0.01). In multivariate adjusted models, the odds for MetS development were greater in patients with serum FGF21 levels in the highest quartile, compared to those in the lowest quartile (3.84, 95% confidence interval: 1.59–9.28). CONCLUSION: Serum FGF21 level was an independent predictor for new-onset MetS in a population-based prospective study.
Biomarkers/blood ; Female ; Fibroblast Growth Factors/*blood ; Humans ; Male ; Metabolic Syndrome/*blood ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Prospective Studies

OBJECTIVE: To investigate the relationship between metabolic syndrome (MetS) and cystatin C in people undergoing healthy examination.
 METHODS: A total of 6 783 subjects were analyzed. They were divided into MetS group (n=1 578), metabolic disturbance (MetD) group (n=3 617) and healthy control (HC) group (n=1 588). The general information, anthropometry, blood sample and urine sample were collected for all the subjects. Multiple logistic regression analysis was used to identify risk factors for MetS and analysis of covariance was used to investigate the correlation between the number of metabolic disturbance components and cystatin C.
 RESULTS: Compared with the HC group, the level of cystatin C significantly increased in MetS and MetD group; compared with MetD group, the level of cystatin C significantly increased in MetS group (P<0.05). After correction by age, sex, smoking, alcohol intake, menopause, waist circumference, body mass index, blood pressure, plasma cholesterol, fasting plasma glucose, estimated glomerular filtration rate, serum uric acid, microalbuminria, high sensitive C-reaction protein and homocysteine, the cystatin C was closely related with MetS (OR=1.951, 95% CI 1.265-3.009, P<0.05). Similarly, the OR value of risk with MetS was increased with the quartile of cystatin C level (P<0.05). In addition, with the increase in metabolic disturbance components, the level of cystatin C was also increased significantly (P<0.01).
 CONCLUSION Serum cystatin C in our study was significantly associated with MetS. Moreover, the level of cystatin C may be correlated with severity of MetD.
Blood Pressure ; Body Mass Index ; Case-Control Studies ; Cystatin C ; blood ; Humans ; Metabolic Syndrome ; blood ; Risk Factors ; Waist Circumference

PURPOSE: The objective of this study was to determine whether the progressive increase of metabolic syndrome (MetS) score, the number of components of MetS, is correlated significantly with increasing pulse pressure (PP). MATERIALS AND METHODS: 4,034 subjects were enrolled from the Cardiovascular Genome Center of Yonsei University (M:F=2344:1690, 55.2 +/- 10.5). Most of the study population were recruited from hypertension clinics, controlled with medications according to JNC7 guidelines. The Asian modified criteria of MetS were applied and MetS score was estimated. The HOMA index for insulin resistance, cholesterol profiles, and anthropometric measurements were assessed. RESULTS: Among 4034 participants, 1690 (41.9%) were classified as MetS. Progressive increase in PP was demonstrated for increasing components of the MetS score. Multiple linear regression analysis with PP as the dependent variable showed that age (beta=0.311, p < 0.001), MetS score (beta=0.226, p < 0.001), male gender (beta=-0.093, p < 0.001) and HOMA index IR (beta=0.033, p=0.03) are significantly associated with PP (R(2)=0.207, p < 0.001). CONCLUSION: The present results from this study demonstrate that increasing MetS score is an independent determinant of increasing PP. The results also demonstrate the independent role of MetS in increasing arterial stiffness and PP.
Adult ; Age Distribution ; Aged ; Blood Pressure ; Female ; Humans ; Male ; Metabolic Syndrome X/*epidemiology/physiopathology ; Middle Aged