No abstract available.
Humans ; Listeria* ; Meningitis, Listeria*

No abstract available.
Listeria* ; Meningitis, Listeria* ; Transplantation*

No abstract available.
Child* ; Humans ; Listeria monocytogenes ; Listeria* ; Listeriosis* ; Meningitis ; Sepsis

Listeriosis in a healthy child is extremely rare. A previously healthy 9-year-old male was admitted with pyrexia, headache and lethargy. The CSF cultures, taken on admission and on the 5th day, showed growth of Listeria monocytogenes. L. monocytogenes was identified by various methods, including polymerase chain reaction(PCR). Serologically, it showed type 1/2a. However, blood cultures, which were taken on the same days, revealed no growth of L. monocytogenes. Ceftriaxone and amikacin had no effect on the progress of the disease. The combination of ampicillin plus gentamicin, which is regarded as the treatment of choice for L. monocytogenes infection, had an effect in this case. Patient showed severe neurological symptoms and signs, such as diplopia, esotropia, nystagmus, ptosis and other meningeal signs during the hospital days, even though all such symptoms and signs were improved at discharge. We report the case with brief review of related literatures.
Amikacin ; Ampicillin ; Ceftriaxone ; Child* ; Diplopia ; Esotropia ; Fever ; Gentamicins ; Headache ; Humans ; Lethargy ; Listeria monocytogenes ; Listeria* ; Listeriosis ; Male ; Meningitis, Listeria*

Listeria monocytogenes is the causative agent in a spectrum of human disease ranging from gastroenteritis to invasive infections such as meningitis, encephalitis, and septicemia. Elderly patients or persons who have lower cell-mediated immunity with predisposing conditions such as transplants, lymphomas, and AIDS, are especially susceptible. The tropism of L.monocytogenes for the central nervous system leads to severe disease, often with high mortality. We report a case of L. monocytogenes meningitis in a 58-year old woman with end stage renal disease. The patient was discharged without neurological sequelae after antibiotic treatment.
Aged ; Central Nervous System ; Encephalitis ; Female ; Gastroenteritis ; Humans ; Immunity, Cellular ; Kidney Failure, Chronic* ; Listeria monocytogenes* ; Listeria* ; Lymphoma ; Meningitis ; Meningitis, Listeria* ; Middle Aged ; Mortality ; Sepsis ; Tropism

Since it has been named as Listeria monocytogenes after its detection in 20th century, listeriosis has been known as a microorganism to parasitize and proliferate in cytoplasm of eucaryotic cell in many researches. As listeriosis has been occurred frequently in malignancy, leukemia, alcoholism, pregnant women, neonates and patients who has been administered immunosuppressants, a declined cell- mediated immune system of these patients has gotten the clinical attention as a common pattern. Infections by listeria have been rarely reported in end stage renal disease patients with a reduction in cell- medicated immune system. Through our experience, we'd like to report a meningitis by Listeria monocytogenes which has not been submitted in Korea yet.
Alcoholism ; Cytoplasm ; Female ; Humans ; Immune System ; Immunosuppressive Agents ; Infant, Newborn ; Kidney Failure, Chronic ; Korea ; Leukemia ; Listeria monocytogenes* ; Listeria* ; Listeriosis ; Meningitis ; Meningitis, Listeria* ; Pregnant Women ; Renal Dialysis*

Infection still remains a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). Patients with SLE are well known to have an increased risk of various opportunistic infections, which can be fatal. Central nervous system (CNS) infections such as meningitis are rare complications to SLE. On occasion, nonspecific neurologic manifestations of infectious meningitis in SLE patients can be confused with neuropsychiatric lupus. Listeria monocytogenes is a less-commonly identified organism causing meningitis in SLE patients. Here, we describe a case of Listeria monocytogenes meningitis presenting with bilateral abducens nerve (sixth cranial nerve) palsy in a patient with SLE, who was successfully treated with systemic antibiotics.
Abducens Nerve ; Abducens Nerve Diseases ; Anti-Bacterial Agents ; Central Nervous System ; Humans ; Listeria ; Listeria monocytogenes ; Lupus Erythematosus, Systemic ; Meningitis ; Meningitis, Listeria ; Neurologic Manifestations ; Opportunistic Infections ; Paralysis

BACKGROUND AND PURPOSE: Encephalitis caused by Listeria monocytogenes (L. monocytogenes) is rare but sometimes fatal. Early diagnosis is difficult using routine cerebrospinal fluid (CSF) tests, while next-generation sequencing (NGS) is increasingly being used for the detection and characterization of pathogens. METHODS: This study set up and applied unbiased NGS to detect L. monocytogenes in CSF collected from three cases of clinically suspected listeria meningoencephalitis. RESULTS: Three cases of patients with acute/subacute meningoencephalitis are reported. Magnetic resonance imaging and blood cultures led to a suspected diagnosis of L. monocytogenes, while the CSF cultures were negative. Unbiased NGS of CSF identified and sequenced reads corresponding to L. monocytogenes in all three cases. CONCLUSIONS: This is the first report highlighting the feasibility of applying NGS of CSF as a diagnostic method for central nervous system (CNS) L. monocytogenes infection. Routine application of this technology in clinical microbiology will significantly improve diagnostic methods for CNS infectious diseases.
Central Nervous System ; Cerebrospinal Fluid ; Communicable Diseases ; Diagnosis ; Early Diagnosis ; Encephalitis ; Humans ; Listeria monocytogenes* ; Listeria* ; Magnetic Resonance Imaging ; Meningitis, Listeria ; Meningoencephalitis* ; Methods

In systemic lupus erythematosus (SLE) patients, immunosuppressive treatment with cytotoxic drugs or corticosteroids, proteinuria, renal insufficiency, and active SLE itself are known as risk factors for serious bacterial infections and opportunistic infections. Several opportunistic infections such as toxoplasmosis, nocardiosis, and cryptococcal meningitis have been reported to occur in patients with SLE and these can mimic neuropsychiatric lupus. Listeria monocytogenes is one of the pathogens of bacterial meningitis that is less commonly identified than Neisseira meningitidis and Streptococcus pneumoniae in adults, and shows the clinical manifestations, such as headache, fever, nausea, vomiting, neck stiffness, mental changes and seizures similar to symptoms and signs of neuropsychiatric lupus. We report a case of Listeria monocytogenes meningitis in a patient with SLE who was admitted because of headache, nausea, vomiting and poor oral intake.
Adrenal Cortex Hormones ; Adult ; Bacterial Infections ; Fever ; Headache ; Humans ; Listeria monocytogenes* ; Listeria* ; Lupus Erythematosus, Systemic* ; Meningitis, Bacterial ; Meningitis, Cryptococcal ; Meningitis, Listeria* ; Nausea ; Neck ; Nocardia Infections ; Opportunistic Infections ; Proteinuria ; Renal Insufficiency ; Risk Factors ; Seizures ; Streptococcus pneumoniae ; Toxoplasmosis ; Vomiting

Brain ; pathology ; Female ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Meningitis, Listeria ; diagnosis ; drug therapy