To evaluate the diagnostic value of lactate dehydrogenase (LDH) in bacterial meningitis (BM) and viral meningitis (VM), LDH was determined simultaneously in cerebrospinal fluid (CSF) and in sera of 89 children suffering from meningitis (51 BM and 38 VM) by 3 time (acute phase, 7-10 days later, and recovering period). Control group consists of 33 normal children. In blood, LDH activity was always elevated, statistically different from control group (p<0.05) but these was no difference between BM and VM. So LDH in sera isn't helpful in the differential diagnosis between BM and VM. In contrast, LDH activity in CSF was highly statistical difference from control group (p<0.001) and there was statistical different between BM and VM. Therefore, LDH activity in CSE has great value in the differential diagnosis between BM and VM; it possesses prognostic value in BM.
Meningitis ; cerebrospinal fluid ; blood ; Meningitis, Bacterial ; Meningitis, Viral

No abstract available.
Cerebrospinal Fluid* ; Child* ; Humans ; Lymphocytosis* ; Meningitis, Bacterial*

No abstract available.
Cerebrospinal Fluid Rhinorrhea ; Meningitis, Bacterial ; Rhinoplasty

Concentration ; Meningitis, Bacterial ; Lactic acid ; Cerebrospinal Fluid

We report a case of severe chemical meningitis complicating iohexol myelography. Cerebrospinal fluid findings include a white blood cell count of 1700(94% polymorphouse cell, 6% lymphocyte ), sugar 20mg/dl and p rotein 170mg/dl. Chemical meningitis can not be distinguished from acute bacterial meningitis on the basis of the clinical findings and cerebrospinal fluid examination. A cerebrospinal fluid gram stain and culture were the only reliable test in deciding the etiology of the meningitis. The authors report this rare complication from iohexol myelography with review of pe rtinent literature.
Cerebrospinal Fluid ; Iohexol* ; Leukocyte Count ; Lymphocytes ; Meningitis* ; Meningitis, Bacterial ; Myelography

We present a case of bacterial menir gitis with spontaneous cerebrospinal rhinorrhea due to bony erosion by pituitary tumor. Brain CT and RI cisternography revealed direct bony erosion of both medial walls of sphenoid sinus which were considered as a portal of entry of bacterial meningitis. He was free from his symptoms by antimicrobial treatment and sugical repair.
Brain ; Cerebrospinal Fluid Rhinorrhea ; Meningitis, Bacterial* ; Pituitary Neoplasms* ; Sphenoid Sinus

Cerebrospinal fluid (CSF) rhinorrhea is classified into traumatic and non-traumatic types. Traumatic CSF rhinorrhea comprises the majority of cases, and major causes include head trauma, rhinologic procedures, and neurosurgery. Non-traumatic (spontaneous) CSF rhinorrhea with normal cerebrospinal pressure is a rare condition, occurring in only 4% of cases. We recently experienced a case of spontaneous CSF rhinorrhea complicated with bacterial meningitis. The defect site was identified in the left sphenoid sinus and was successfully repaired with a nasoseptal flap under an endoscopic approach. We present the etiology, classification, and treatment of this rare disease entity with a review of the literature.
Cerebrospinal Fluid ; Cerebrospinal Fluid Rhinorrhea* ; Classification ; Craniocerebral Trauma ; Meningitis, Bacterial ; Neurosurgery ; Rare Diseases ; Sphenoid Sinus

We reported a case of nontraumatic cerebrospinal fluid fistula who had concomittantly CSF rhinorrhea, pneumocephalus and bacterial meningitis. By metrizamide CT cisternography, we found her CSF fistula was likely to be on the right lateral wall of sphenoidal sinus. She was recovered from her symptoms by medical treatment and has been free of CSF rhinorrhea or meningitis without surgical repair of CSF fistula during recent 1 year follow up.
Cerebrospinal Fluid* ; Fistula* ; Follow-Up Studies ; Meningitis ; Meningitis, Bacterial ; Metrizamide ; Pneumocephalus

PURPOSE: This study was launched to classify subjects of the CSF examination and improve early diagnosis of meningitis and its treatment in children who have had a first febrile seizure. METHODS: From March 1995 to September 2003, children aged 3 months to 5 years who had had treatment for febrile seizure were analyzed as to their age at first seizure, type of seizure, CSF examination, and prevalence of meningitis. RESULTS:The largest age group distribution among the 780 children was 356(45.6%) children who were under 18 months. One hundred ninteen(15.3%) patients received the CSF examination, and out of those 68(19.1%) were less than 18 months old. Twenty five(3.2%) children were diagnosed with meningitis; those less than 18 months old were 15(4.2%). Two(0.2%) were diagnosed as bacterial meningitis. Out of 780 patients 599(76.8%) were simple febrile seizure patients. Out of 32(5.3%) who received the CSF examination, nine were diagnosed as meningitis. In complex febrile seizure, 86(52.1 %) out of 165(21.2%) received CSF examinations and 16(9.7%) of those were diagnosed as meningitis. Thus, there was a higher prevalence of meningitis in children presenting complex febrile seizure. CONCLUSION: To diagnose meningitis with the CSF examination in the first febrile seizure, the patient's general condition, such as clinical symptoms and types of seizure, are more important than the ages of the patients. We suggest that experienced physicians should be concerned with doing an early diagnosis of meningitis and thus reduce the number of CSF examinations of children with febrile seizures.
Cerebrospinal Fluid ; Child ; Early Diagnosis ; Humans ; Infant ; Meningitis ; Meningitis, Bacterial ; Prevalence ; Seizures ; Seizures, Febrile*

PURPOSE: The purpose of this study was to evaluate the usefulness of computed tomography(CT) and magnetic resonance imaging(MRI) in experimental bacterial meningitis. MATERIALS AND METHODS: CT and MR images of experimental bacterial meningitis were obtained after inoculation of 1ml suspension of 106/ml Staphylococcusaureus directly into the supratentorial arachnoid space of 18 New Zealand white rabbits. Each animal was studied with both Pre-enhanced and post-enhanced CT and MRI at 12, 24, 48 hours and 1 week. Cerebrospinal fluid of all of18 rabbits were sampled and cultured for bacterial growth. RESULTS: All of 18 rabbits had the clinical symptoms such as neck stiffness and anorexia within 24 hours after the inoculation. Cerebrospinal fluid cultures werepositive for Staphylococcus sureus growth. Gd-enhanced MRI exhibited diffuse enhancement along the thickened supratentorial meninges earlier than CT. in Gd-enhanced MRI, the mean contrast enhancement ratio(CER) at supratentorial meninges increased to 1.93 at 12 hours and 2.99 at 24 hours from 1.06 at 0 hour. Histologic evaluation demonstrated inflammatory cell infiltration into the meninges. MRI also identified the complications of mening it is such as ependymitis and hydrocephalus more effectively than CT. CONCLUSION: These results indicatedthat Gd-enhanced MRI detected earlier the abnormal findings of bacterial meningitis and evaluated more effectively the complications of mening it is compared with CT. MRI was more useful than CT in evaluation of the bacterial meningitis.
Animals ; Anorexia ; Arachnoid ; Cerebrospinal Fluid ; Hydrocephalus ; Magnetic Resonance Imaging* ; Meninges ; Meningitis ; Meningitis, Bacterial* ; Neck ; Rabbits ; Staphylococcus