1.F-18 Fluorodeoxyglucose PET/CT and Post Hoc PET/MRI in a Case of Primary Meningeal Melanomatosis.
Hong Je LEE ; Byeong Cheol AHN ; Seong Wook HWANG ; Suk Kyong CHO ; Hae Won KIM ; Sang Woo LEE ; Jeong Hyun HWANG ; Jaetae LEE
Korean Journal of Radiology 2013;14(2):343-349
Primary meningeal melanomatosis is a rare, aggressive variant of primary malignant melanoma of the central nervous system, which arises from melanocytes within the leptomeninges and carries a poor prognosis. We report a case of primary meningeal melanomatosis in a 17-year-old man, which was diagnosed with 18F-fluorodeoxyglucose (F-18 FDG) PET/CT, and post hoc F-18 FDG PET/MRI fusion images. Whole-body F-18 FDG PET/CT was helpful in ruling out the extracranial origin of melanoma lesions, and in assessing the therapeutic response. Post hoc PET/MRI fusion images facilitated the correlation between PET and MRI images and demonstrated the hypermetabolic lesions more accurately than the unenhanced PET/CT images. Whole body F-18 FDG PET/CT and post hoc PET/MRI images might help clinicians determine the best therapeutic strategy for patients with primary meningeal melanomatosis.
Adolescent
;
Brain Neoplasms/*diagnosis/radionuclide imaging
;
Fluorodeoxyglucose F18/diagnostic use
;
Humans
;
*Magnetic Resonance Imaging
;
Male
;
Melanoma/*diagnosis/radionuclide imaging
;
Meningeal Neoplasms/*diagnosis/radionuclide imaging
;
*Positron-Emission Tomography and Computed Tomography
;
Radiopharmaceuticals/diagnostic use
;
Whole Body Imaging
2.A Rare Case of Primary Hyperparathyroidism Associated with Primary Aldosteronism, Hurthle Cell Thyroid Cancer and Meningioma.
You Lim KIM ; Young Woo JANG ; Jin Taek KIM ; Su Ah SUNG ; Tae Seok LEE ; Won Mi LEE ; Hyo Jeong KIM
Journal of Korean Medical Science 2012;27(5):560-564
Multiple endocrine neoplasia type 1 (MEN1) syndrome includes varying combinations of endocrine and non-endocrine tumors. There are also a considerable number of atypical MEN1 syndrome. In this case, a 68-yr-old woman was referred to the Department of Endocrinology for hypercalcemia. Five years ago, she had diagnosed as primary hyperaldosteronism and now newly diagnosed as parathyroid hyperplasia with laboratory and pathologic findings. Hurthle-cell thyroid cancer was also resected during the parathyroid exploration and small meningioma was found on brain MRI. Her general condition has markedly improved and her adrenal mass and meningioma are being closely observed now. We could find the loss of heterozygosity of the MEN1 locus in parathyroid glands, suggesting a MEN1-related tumor, but not a germline mutation. Considering a variety of phenotypic expression and a limitation of current molecular analysis, periodic follow up will be needed in patients with a MEN1-like phenotype.
Aged
;
Base Sequence
;
Brain/radionuclide imaging
;
Female
;
Humans
;
Hyperaldosteronism/complications/*diagnosis
;
Hyperparathyroidism, Primary/*diagnosis/etiology/pathology
;
Loss of Heterozygosity
;
Magnetic Resonance Imaging
;
Meningeal Neoplasms/complications/*diagnosis/radionuclide imaging
;
Meningioma/complications/*diagnosis/radionuclide imaging
;
Mutation
;
Parathyroid Glands/pathology
;
Proto-Oncogene Proteins/genetics/metabolism
;
Sequence Analysis, DNA
;
Thyroid Neoplasms/complications/*diagnosis/pathology
;
Tomography, X-Ray Computed