Objective To investigate the effect of Musk Hemorrhoids Ointment Combined with psychological intervention in patients with perianal eczema and the effect on the quality of life of patients. Methods 70 patients with perianal eczema were randomly divided into control group (n=35) and observation group (n=35). The control group using triamicinolone acetonide acetate and miconazole nitrate neomycin sulfate cream with the treatment, the observation group with musk hemorrhoids ointment combined with psychological intervention treatment by SF-36 life quality scale of two groups before and after treatment to assess the quality of life, compared 2 groups of clinical curative effect and influence on the quality of life of patients. Results The observation group after treatment itching, exudation and lesion area and the symptoms and signs improved time shorter than the control group (P<0.05); quality of life score of SF-36 in observation group after treatment were higher than those in control group (P<0.05); the observation group after 2 weeks of treatment, the clinical efficiency and control group had significant difference (P<0.05). Conclusion Patients with perianal eczema with musk hemorrhoids ointment combined with psychological intervention treatment effect is ideal, it is worthy of popularization and application.

Objective To explore the value of the molecular probe USPIO-PEG-sLeX on nasopharyngeal carcinoma xenograft in nude mice.Methods The USPIO nanoparticles was synthesized by physical deposition method,and which was modified by PEG to synthesize USPIO-PEG-sLeX .The nude mice of nasopharyngeal carcinoma xenograft were divided into experimental and control groups.USPIO-PEG-sLeX and USPIO-PEG were injected into nude mice of experimental and control groups by caudal vein,respectively.MR T2 mapping imaging was scanned before and after the injection,and analyzed the changes of T2 values between experimental and control groups. Results USPIO-PEG-sLeX had a good representation.The non-enhanced T2 values between control and experimental group had no statistical significance (P >0.05).However,T2 values of the mice in two groups before and after injections were statistically significant (P <0.05);and T2 values of experimental group were much lower than that of the control group after the injection,additionally,the difference of enhanced rate between the two groups was statistically significant (P <0.05).Conclusion USPIO-PEG-sLeX magnetic nanoparticles is potential to be a targeted contrast agent to ELAM-1 expression of nasopharyngeal carcinoma,and can be valuable in non-invasive dynamic monitoring the expression of ELAM-1.

Objective:To investigate the changes of the zygoma, circumzygomatic sutures, and zygomatic arch in children after trans-sutural distraction osteogenesis (TSDO).Methods:A retrospective analysis was performed on skull CT data of cleft lip and palate patients who underwent TSDO to correct midfacial hypoplasia between 2005 and 2019 in Peking University Third Hospital. The Mimics 20.0 software was used for three-dimensional(3D) model reconstruction to observe the morphological changes of the zygoma, circumzygomatic sutures, and zygomatic arch at the end of the traction period after TSDO. Measurements were taken and analyzed for the distances from mp point to 3D reference planes, zygoma height, zygoma width 1, zygoma width 2, zygoma thickness, zygoma volume, zygomaticomaxillary suture width, zygomaticotemporal suture width, zygomaticofrontal suture width, zygomatic arch length, and distances from zygomatic arch landmarks (tp point, zy point, and ju point) to the 3D reference planes. All data were divided into cleft and non-cleft sides. GraphPad Prism 9.4.1 software was used to analyze the changes before and after TSDO. Measurement data of normal distribution was expressed by ± s and the comparison between groups before and after traction was analyzed by paired t-test. Measurement data of non-normal distribution was expressed by M(IQR) and the comparison between groups before and after traction was analyzed by paired Wilcoxon test. If P<0.05, the difference was statistically significant. Results:A total of 27 patients were included in the study, including 23 males and 4 females, with a mean age of (11.19±2.35) years (5-15 years). Of these patients, 10 had bilateral cleft lip and palate, and 17 had unilateral cleft lip and palate (9 on the left side and 8 on the right side). The average traction period was (40.26±11.43) days. The midfacial depression of the patients was corrected after TSDO, and the zygoma grew forward, downward, and horizontally. The circumzygomatic sutures shifted forward. The zygomatic arch showed forward and downward growth. The measurements of zygoma showed that the mp point moved forward by (7.82±3.95) mm on the cleft side and 4.26(5.72) mm on the non-cleft side with statistical differences ( P<0.05). The mp point moved slightly downward, and outward after TSDO compared to before surgery, and these differences were statistically significant ( P<0.05). After TSDO, the zygoma height, width, and volume were all increased compared to preoperative levels, and these differences were statistically significant ( P<0.05). The width of the lower part of the zygomatic bone showed the most significant change, increasing by 4.33(5.17) mm on the cleft side and (3.42±2.67) mm on the non-cleft side and these differences were statistically significant ( P<0.05). There was no statistically significant difference in the thickness of the zygoma after TSDO compared to before surgery ( P>0.05). The widths of circumzygomatic sutures were all increased after TSDO compared to before surgery, and these differences were statistically significant ( P<0.05). The width of zygomaticofrontal suture showed the greatest increase and the width of zygomaticomaxillary suture showed the smallest increase. The length of the zygomatic arch increased after TSDO compared to before surgery, with an increase of (4.78±2.71) mm on the cleft side and (2.03±1.48) mm on the non-cleft side, and these differences were statistically significant ( P<0.05). There was no statistically significant difference in the position of the tp point after TSDO compared to before surgery ( P>0.05), while the position of the zy point and the ju point moved significantly forward and downward, and these differences were statistically significant ( P<0.05). In the horizontal direction, there was no statistically significant difference in the position of the zy point and ju point after TSDO compared to before surgery ( P>0.05). Conclusion:After TSDO, the zygoma shows three-dimensional growth with significant increases in height, width, and volume. The position of zygoma moves forward, downward, and outward. The circumzygomatic sutures widen due to the distraction force, and the zygomatic arch grows forward and downward, with an increase in length.

Objective To explore the effect of standing-sitting Baduanjin exercise in postoperative rehabilitation of breast cancer patients. Methods Totally 70 cases of patients with breast cancer postoperation were randomly assigned to the control group and the experimental group. Patients in the control group received routine postoperative nursing, while patients in the experimental group adopted standing-sitting Baduanjin exercise. Fatigue condition and functional recovery of ill limb were compared through evaluation by BFI and functional assessment of ill limb.Results The total BFI score of fatigue in the experimental group was (3.29± 0.42) points 1 month after operation, and was (3.28±0.45) points 3 months after operation. They were all superior than the score of control group (t=-4.007,-3.996;P<0.01). Limb function of 96.8% patients were completely recovered in the experimental group 1 month after operation, while just 75.8% patients in the control group. 3 months after operation, 100% patients were completely recovered in the experimental group, and in the control group, it was 81.8% (χ2=4.233,4.264;P<0.05).Conclusions Suitability standing-sitting Baduanjin exercise can relieve the fatigue symptom of patients with breast cancer postoperation, and delay the aggravation of symptoms during chemotherapy.

Objective:To investigate the changes of the zygoma, circumzygomatic sutures, and zygomatic arch in children after trans-sutural distraction osteogenesis (TSDO).Methods:A retrospective analysis was performed on skull CT data of cleft lip and palate patients who underwent TSDO to correct midfacial hypoplasia between 2005 and 2019 in Peking University Third Hospital. The Mimics 20.0 software was used for three-dimensional(3D) model reconstruction to observe the morphological changes of the zygoma, circumzygomatic sutures, and zygomatic arch at the end of the traction period after TSDO. Measurements were taken and analyzed for the distances from mp point to 3D reference planes, zygoma height, zygoma width 1, zygoma width 2, zygoma thickness, zygoma volume, zygomaticomaxillary suture width, zygomaticotemporal suture width, zygomaticofrontal suture width, zygomatic arch length, and distances from zygomatic arch landmarks (tp point, zy point, and ju point) to the 3D reference planes. All data were divided into cleft and non-cleft sides. GraphPad Prism 9.4.1 software was used to analyze the changes before and after TSDO. Measurement data of normal distribution was expressed by ± s and the comparison between groups before and after traction was analyzed by paired t-test. Measurement data of non-normal distribution was expressed by M(IQR) and the comparison between groups before and after traction was analyzed by paired Wilcoxon test. If P<0.05, the difference was statistically significant. Results:A total of 27 patients were included in the study, including 23 males and 4 females, with a mean age of (11.19±2.35) years (5-15 years). Of these patients, 10 had bilateral cleft lip and palate, and 17 had unilateral cleft lip and palate (9 on the left side and 8 on the right side). The average traction period was (40.26±11.43) days. The midfacial depression of the patients was corrected after TSDO, and the zygoma grew forward, downward, and horizontally. The circumzygomatic sutures shifted forward. The zygomatic arch showed forward and downward growth. The measurements of zygoma showed that the mp point moved forward by (7.82±3.95) mm on the cleft side and 4.26(5.72) mm on the non-cleft side with statistical differences ( P<0.05). The mp point moved slightly downward, and outward after TSDO compared to before surgery, and these differences were statistically significant ( P<0.05). After TSDO, the zygoma height, width, and volume were all increased compared to preoperative levels, and these differences were statistically significant ( P<0.05). The width of the lower part of the zygomatic bone showed the most significant change, increasing by 4.33(5.17) mm on the cleft side and (3.42±2.67) mm on the non-cleft side and these differences were statistically significant ( P<0.05). There was no statistically significant difference in the thickness of the zygoma after TSDO compared to before surgery ( P>0.05). The widths of circumzygomatic sutures were all increased after TSDO compared to before surgery, and these differences were statistically significant ( P<0.05). The width of zygomaticofrontal suture showed the greatest increase and the width of zygomaticomaxillary suture showed the smallest increase. The length of the zygomatic arch increased after TSDO compared to before surgery, with an increase of (4.78±2.71) mm on the cleft side and (2.03±1.48) mm on the non-cleft side, and these differences were statistically significant ( P<0.05). There was no statistically significant difference in the position of the tp point after TSDO compared to before surgery ( P>0.05), while the position of the zy point and the ju point moved significantly forward and downward, and these differences were statistically significant ( P<0.05). In the horizontal direction, there was no statistically significant difference in the position of the zy point and ju point after TSDO compared to before surgery ( P>0.05). Conclusion:After TSDO, the zygoma shows three-dimensional growth with significant increases in height, width, and volume. The position of zygoma moves forward, downward, and outward. The circumzygomatic sutures widen due to the distraction force, and the zygomatic arch grows forward and downward, with an increase in length.

BACKGROUND: The phenotype maintenance of diced cartilage is a very important factor to reduce cartilage absorption rate in augmentation rhinoplasty. A novel method which combined diced cartilage with chondrocyte spheroids in gelatin methacrylate (GelMA) hydrogel may have potentially good performance in phenotype maintenance, and is worth exploring. METHODS: The complex grafts formed by loading diced cartilage with chondrocyte spheroids into GelMA hydrogel were used as the experimental group, and the grafts formed of diced cartilage in GelMA were used as the control group.The two groups of grafts were implanted subcutaneously in nude mice. After 1 month and 3 months, the grafts were taken for general observation and histological analysis. The diameter changes of cartilage, the nuclei loss of chondrocyte, and glycosaminoglycan secretion were analyzed. RESULTS: Chondrocyte spheroids with obvious proliferation can be seen in the experimental group. Some diced cartilages had become a whole through the interconnection of chondrocyte spheroids. In addition, the diameter of the chondrocyte spheroids—diced cartilage complex in the experimental group increased significantly, and its nuclei loss rate was less than 1/2 of that in the control group. The maintenance of proteoglycans in diced cartilages in the experimental group was significantly better than that in the control group. CONCLUSION The combination of diced cartilage with chondrocyte spheroids in GelMA hydrogel can significantly reduce the absorption of cartilage extracellular matrix, enhance phenotype maintenance during subcutaneous ectopic implantation, and can produce inter-chondral connections.

Objective:To summarize the concept, theoretical basis, evaluation tools and mechanisms, influencing factors, and intervention measures of kinesiophobia.Methods:The literature on kinesiophobia in patients undergoing total knee replacement was electronically searched on databases such as China National Knowledge Infrastructure, China Biology Medicine disc, WanFang Data, PubMed, CINAHL, Web of Science, Embase, Scopus, PsycINFO, Cochrane Library. The search period was from database establishment to June 24, 2023. This study extracted and analyzed data from the included literature.Results:A total of 32 articles were included. The Tampa Scale for Kinesiophobia was a widely used tool for evaluating kinesiophobia. The influencing factors of kinesiophobia were demographic and disease factors, body motor function, and psychological and social factors. The intervention measures for kinesiophobia mainly included cognitive behavioral intervention, pain health education, exercise, art video or music intervention, multidisciplinary collaborative intervention, and so on.Conclusions:The concept and theoretical basis of kinesiophobia are not yet complete. It is necessary to revise and improve the theoretical model and assessment tool for kinesiophobia and construct an intervention program for kinesiophobia in combination with the concept of rapid rehabilitation.

OBJECTIVE To analyze the public participation mechanism of National Institute for Health and Care Excellence （NICE） health technology assessment in England and to provide experience for the dynamic adjustment of Chinese medical insurance catalog. METHODS By retrieving related literature and official websites， types and mechanisms of public participation （management organization， selection method， participation mode， evaluation feedback） in NICE health technology assessment were analyzed comprehensively； and based on this， suggestions were put forward to adjust the public participation in Chinese medical insurance catalog. RESULTS & CONCLUSIONS The current public participation types of NICE health technology assessment were patient and carer organizations， HTA committee lay members， patient expert and public observers. At the management level， NICE has set up a public participation team and made guidelines on public participation matters. For different public participation types， NICE has established different selection procedures， such as expression of interest， NICE invitation， open recruitment， nomination， NICE decision， etc. The public participation types are various and in the whole assessing process from the initial determination of the scope of the health technology assessment to the final appeal. Also， NICE has established a flexible and dynamic evaluation feedback system to optimize the way of public participation and the health technology assessment process； NICE has undertaken extensive international cooperation and exchanges to promote public participation at the national and international levels. It is suggested that our country should combine the national conditions， clarify the channel of public participation in health technology evaluation， set up a working group of public participation affairs， strengthen patients’ participation in evaluation and feedback， improve decision-making transparency， and improve the public participation mechanism of health technology evaluation from the aspects of channel opening， management mechanism， evaluation feedback， information disclosure and so on.

Objective To compare the effects of different stent configurations on shunt failure,hepatic encephalopathy,and hepatic myelopathy after transjugular intrahepatic portosystemic shunt (TIPS).Methods From March 2014 to June 2015,the clinical data of 73 hospitalized,patients who met the inclusion and exclusion criteria,and underwent TIPS for upper gastrointestinal hemorrhage caused by cirrhotic portal hypertension were retrospectively analyzed.According to the stent configuration during operation,patients were divided into simple coated stent group (hepatic vein,portal vein and hepatic parenchyma coated stent,23 cases),simulated Viatorr stent group (hepatic vein and hepatic parenchyma coated stent plus portal vein bare stent,27 cases) and combined stent group (hepatic vein and portal vein hare stent plus hepatic parenchyma coated stent,23 cases).Patients were followed up for one year,the incidences of shunt failure,hepatic encephalopathy and hepatic myelopathy within one year after TIPS of three groups were compared.Chi-square test,Fisher exact probability method and variance analysis were performed for comparison among groups.Cox regression analysis was used for difference analysis in imbalance of variables and incidence of outcome events among the three groups.Results The portal vein pressure gradient of simple coated stent group,simulated Viatorr stent group and combined stent group decreased from (22.15±4.52),(23.01±5.48) and (21.13±4.49) mmHg (1 mmHg=0.133 kPa) to (9.15±2.94),(11.20±3.27) and (8.75+4.06) mmHg after operation,respectively.Before and after operation,the differences in portal venous pressure gradient were statistically significant of three groups (t=10.488,7.188 and 7.850,all P＜0.05).The shunt failure rates of simple coated stent group,simulated Viatorr stent group and combined stent group were 13.0％ (3/23),18.5％ (5/27) and 30.4％ (7/23),respectively.The results of Cox regression analysis indicated that there was no statistically significant difference in shunt failure rates among different stent configurations after TIPS (P=0.339).The incidences of hepatic encephalopathy of simple coated stent group,simulated Viatorr stent group and combined stent group postoperative were 69.6％ (16/23),33.3％ (9/27) and 30.4％ (7/23),respectively,the difference was not statistically significant among the three groups (P＞ 0.05).The results of Cox regression analysis showed that the relative ratio values (95％ confidence interval) of incidence of postoperative hepatic encephalopathy of simple coated stent group compared with simulated Viatorr stent group and combined stent group were 2.901 (1.279 to 6.584) and 2.735 (1.123 to 6.658),and the differences were statistically significant (both P＜0.05).The incidences of hepatic myelopathy of simple coated stent group,simulated Viatorr stent group and combined stent group were 8.7％ (2/23),3.7％ (1/27) and 4.3％ (1/23),respectively,and there was no statistically significant difference in the incidence of hepatic myelopathy among three groups after operation (P＞0.05).During one-year follow-up,among 73 patients,two patients died,one in simple coated stent group and the other in combined stent group.The one-year survival rate after TIPS was 97.3％.Conclusions One year after operation,the incidences of shunt failure are similar between simple coated stent group,simulated Viatorr stent group and combined stent group.One year after operation,the incidence of hepatic encephalopathy is similar between simulated Viatorr stent group and combined stent group which are both lower than that of simple coated stent.The incidence of hepatic myelopathy is low,and its association with TIPS remains to be further investigated.

Objective:To evaluate the improvement of nasal appearance, symptoms and psychological burden in patients with secondary cleft rhinoplasty by using retrospective research methods, through preoperative and postoperative questionnaires.Methods:Twenty-three cleft lip patients that underwent surgery in our unit since April 2016 were enrolled in this study. The self-designed questionnaire was used to explore the changes of patients before and after the operation. The questionnaire star was utilized to collect the data, and after the data was sorted and summarized, SPSS 20.0 was used for analysis and statistics.Results:The average follow-up time was 28.9 months. The total score of ROE satisfaction before surgery was 46.74 points, while after surgery it reached 63.04 points ( t=4.10, P<0.01); the self-scores of nasal shape were significantly improved after surgery; but there was no significant change in the ventilation function in the VAS scale before and after the operation; the nasal symptoms and psychological status in the SNOT-22 questionnaire, such as, nasal congestion, embarrassment, depression, restlessness and irritability, were significantly improved ( P<0.05). Conclusions:Our semi-autonomous designed questionnaire can be used to effectively evaluate the satisfaction, nasal shape, and symptoms of patients with nasal deformity secondary to cleft lip. Data analysis shows that our secondary cleft lip rhinoplasty for cleft lip and palate can improve patients′ satisfaction after the repair, as well as nose shape and function, at the same time the psychological burden caused by it.