Objective:To evaluate the correlation between the timed up and go(TUG)test and fall risks in elderly frail patients.Methods:From July to September 2019, elderly frail patients who were treated at the cardiovascular department of our hospital were enrolled.Basic clinical data and fall-related information of patients were collected.Patients were divided into the fall group and the non-fall group.Results on the body mass index(BMI), TUG, 4-meter maximum walking speed(4 m MWS)and Barthel index were compared between the two groups.The correlation between TUG and each indicator was examined.Multivariate Logistic regression analysis was used to analyze the correlation between the TUG and falls in elderly patients.Results:A total of 96 eligible patients were enrolled, including 35 in the fall group and 61 in the non-fall group.The average TUG time was longer in the fall group than in the non-fall group(16.45±6.44 s vs.10.17±2.91 s, t=-6.556, P<0.001). The correlation analysis results showed that the TUG was correlated with falls and 4 m MWS( r=0.582 and 0.875, both P<0.001). Multivariate Logistic regression analysis showed that the TUG( OR=1.201, 95% CI: 1.111-1.470, P=0.004)and 4 m MWS( OR=1.146, 95% CI: 1.063-1.244, P=0.015)were risk factors for falls. Conclusions:The TUG is correlated with fall risks in elderly frail patients and should be recommended as a routine test in clinical practice.

Objective To investigate effect of functional exercise and psychological rehabilitation nursing in patients with lower extremity arteriosclerosis obliterans after stent implantation.Methods A total of 78 lower extremity arterial occlusive disease cases with stent implantation in our hospital were randomly divided into observation group and control group,given postoperative functional exercise and mental rehabilitation,routine nursing,respectively.Clinical nursing efficacy and complications were compared between two groups.Results After half-year nursing and treatment,the indicators of two groups were significantly improved (P ＜ 0.05),but there was no significant difference in antde branchial index (ABI) between the two groups (P ＞ 0.05),transcutaneous oxygen pressure (TcPO2) and claudication distance (DOC) in the observation group was significantly better than that in the control group (P ＜ 0.05).The observation group was better curative efficacy and lower incidence of complications than the control group (P ＜ 0.05).Conclusion Functional exercise and psychological rehabilitation can improve the nursing results,reduce complications,and promote recovery.

Objective To investigate effect of functional exercise and psychological rehabilitation nursing in patients with lower extremity arteriosclerosis obliterans after stent implantation.Methods A total of 78 lower extremity arterial occlusive disease cases with stent implantation in our hospital were randomly divided into observation group and control group,given postoperative functional exercise and mental rehabilitation,routine nursing,respectively.Clinical nursing efficacy and complications were compared between two groups.Results After half-year nursing and treatment,the indicators of two groups were significantly improved (P ＜ 0.05),but there was no significant difference in antde branchial index (ABI) between the two groups (P ＞ 0.05),transcutaneous oxygen pressure (TcPO2) and claudication distance (DOC) in the observation group was significantly better than that in the control group (P ＜ 0.05).The observation group was better curative efficacy and lower incidence of complications than the control group (P ＜ 0.05).Conclusion Functional exercise and psychological rehabilitation can improve the nursing results,reduce complications,and promote recovery.

Pancreatic cancer is a more aggressive and refractory malignancy. Resistance and toxicity limit drug efficacy. Herein, we report a lower toxic and higher effective miriplatin (MPt)-loaded liposome, LMPt, exhibiting totally different anti-cancer mechanism from previously reported platinum agents. Both in gemcitabine (GEM)-resistant/sensitive (GEM-R/S) pancreatic cancer cells, LMPt exhibits prominent anti-cancer activity, led by faster cellular entry-induced larger accumulation of MPt. The level of caveolin-1 (Cav-1) determines entry rate and switch of entry pathways of LMPt, indicating a novel role of Cav-1 in nanoparticle entry. After endosome-lysosome processing, in unchanged metabolite, MPt is released and targets mitochondria to enhance binding of mitochondria protease LONP1 with POLG and TFAM, to degrade POLG and TFAM. Then, via PINK1-Parkin axis, mitophagy is induced by POLG and TFAM degradation-initiated mitochondrial DNA (mtDNA) replication blocking. Additionally, POLG and TFAM are identified as novel prognostic markers of pancreatic cancer, and mtDNA replication-induced mitophagy blocking mediates their pro-cancer activity. Our findings reveal that the target of this liposomal platinum agent is mitochondria but not DNA (target of most platinum agents), and totally distinct mechanism of MPt and other formulations of MPt. Self-assembly offers LMPt special efficacy and mechanisms. Prominent action and characteristic mechanism make LMPt a promising cancer candidate.