1.Teaching of central venous catheterization in graduate students of institute of anaesthesiology
Chinese Journal of Medical Education Research 2011;10(2):150-153
In the teaching of central venous catheterization in graduate students of Institute of Anaesthesiology, teachers use traditional teaching method, multimedia method, simulation method and clinical training. It can not only make teaching contents richer and more vivid, but also increase students' interest, thus greatly enhancing teaching results.
2.Evaluation on the efficacy of pamidronate disodium in treatment of osteocarcinoma
Chinese Journal of Biochemical Pharmaceutics 2015;(8):131-133
Objective To investigate the efficacy of disodium pamidronate in treatment of bone metastasis cancer .Methods 50 cases of bone metastasis cancer were divided into control group and experimental group according to different medication, 25 cases in each group.Control group was treated by chemotherapy, experimental group was treated on the basis of control group with disodium pamidronate 45 mg+0.9%sodium chloride solution 500 mL, intravenous drip.Pain maintenance time, patient pain grading and serum NTx levels were compared after treatment.ResuIts Compared with control group,pain maintenance time of experimental group was longer(P <0.05),pain level overall score was lower,NTx was lower(P <0.05). ConcIusion Disodium pamidronate can inhibit bone metastasis cancer patients with the degree of pain, reduce the levels of serum NTx.
3.MCU selection analysis in portable electronic medical instrument design.
Mengxing LIU ; Shuming YE ; Zhi XU ; Hang CHEN
Chinese Journal of Medical Instrumentation 2014;38(3):202-206
Around the features of low power and high integration of portable electronic medical equipment design, the primary low power MCU series from the current semiconductor manufacturers were compared. The analysis results showed that the 32-bit MCUs based on the low cost and high energy efficient ARM Cortex-M architectures, have comprehensive advantages on power level, operational performance and integrated peripherals obviously.
Electronics, Medical
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instrumentation
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Equipment Design
4.Wearable Medical Devices' MCU Selection Analysis Based on the ARM Cortex-MO+ Architecture.
Zaoquan WU ; Mengxing LIU ; Liping QIN ; Shuming YE ; Hang CHEN
Chinese Journal of Medical Instrumentation 2015;39(3):192-196
According to the characteristics of low cost, high performance, high integration and long battery life of wearable medical devices, the mainstream low-power microcontroller(MCU) series were compared, and came to the conclusion that the MCU series based on ARM Cortex-M0+ architecture were suitable for the development of wearable medical devices. In aspects of power consumption, operational performance, integrated peripherals and cost, the MCU series based on Cortex-M0+ architecture of primary semiconductor companies were compared, aimed at providing the guides of MCU selection for wearable medical devices.
Durable Medical Equipment
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Electric Power Supplies
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Monitoring, Ambulatory
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instrumentation
5.Optimal design of portable ambulatory blood pressure monitor based on STM32L.
Mengxing LIU ; Lechuan ZHOU ; Chao HUANG ; Shuming YE ; Hang CHEN
Chinese Journal of Medical Instrumentation 2014;38(5):345-349
Based on the 32-bit ultra low power microcontroller STM32L151RBT6 using ARM Cortex-M3 kernel, the portable ambulatory blood pressure monitor powered by two AA batteries was designed. In order to insure the stability of power supply and prevent overpressure of cuff, super capacitor technology and new kind of safety logic circuits were used. The experimental result shows that: this solution is accurate and stable, which has high safety coefficient and a great clinical application value.
Blood Pressure Monitoring, Ambulatory
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instrumentation
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Equipment Design
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Humans
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Software
6.A Mattress System of Recognizing Sleep Postures Based on BCG Signal.
Mengxing LIU ; Liping QIN ; Shuming YE
Chinese Journal of Medical Instrumentation 2019;43(4):243-247
Sleep posture recognition is the core index of diagnosis and treatment of positional sleep apnea syndrome. In order to detect body postures noninvasively, we developed a portable approach for sleep posture recognition using BCG signals with their morphological difference. A type of piezo-electric polymer film sensor was applied to the mattress to acquire BCG, the discrete wavelet transform with cubic B-spline was used to extract characteristic parameters and a naive Bayes learning phase was adapted to predict body postures. Eleven healthy subjects participated in the sleep simulation experiments. The results indicate that the mean error obtained from heart rates was 0.04±1.3 beats/min (±1.96 SD). The final recognition accuracy of four basic sleep postures exceeded 97%, and the average value was 97.9%. This measuring system is comfortable and accurate, which can be streamlined for daily sleep monitoring application.
Bayes Theorem
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Beds
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Humans
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Polysomnography
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instrumentation
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Posture
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Sleep
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Sleep Apnea Syndromes
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diagnosis
7. A Study on the establishment of immune thrombocytopenia model induced by anti-platelet GPⅠbα antibodies
Kangxi ZHOU ; Rong YAN ; Mengxing CHEN ; Jun LIU ; Qingya CUI ; Renping HU ; Yancai LIU ; Yang ZHANG ; Changgeng RUAN ; Kesheng DAI
Chinese Journal of Hematology 2017;38(5):390-393
Objective:
To establish primary immune thrombocytopenia (ITP) animal model induced by anti-platelet membrane glycoprotein GPⅠbα antibodies AN51 and R300.
Methods:
Twenty guinea pigs (6-8 week) were divided into 4 groups. Five guinea pigs in each group were intravenously injected with different doses of AN51 (0.05, 0.1, 0.2 μg/g) and 0.2 μg/g IgG as control. The whole blood was collected from inner angular venous plexus. Platelets number was determined by an automated cell counter and Swiss-Jim method. Then, the similar protocol was used to establish ITP nude mice model by intraperitoneal injection of different concentrations of anti-platelet GPⅠbα antibody R300, respectively.
Results:
①Five minutes after intravenous injection of AN51 at 0.05, 0.1 and 0.2 μg/g, the platelet counts of guinea pigs reduced about 0-5%, 50%-60% and 70%-80% compared to the control group, respectively. The difference was statistically significant (
8.Risk factors of abnormal urinary albumin/creatinine ratio in people with obesity
Zhe CAO ; Tongyue YANG ; Shiyu LIU ; Mengxing PAN ; Xuyang GONG ; Qianshuai LI ; Jiao WANG ; Lin ZHAO ; Guijun QIN ; Yanyan ZHAO
Chinese Journal of Endocrinology and Metabolism 2024;40(3):186-191
Objective:To explore the clinical characteristics and risk factors of abnormal urinary albumin/creatinine ratio(UACR) in obese population.Methods:Baseline data from 2011 to 2012 in Henan Sub-center of"Risk Evaluation of cAncers in Chinese diabeTic Individuals: A lONgitudinal(REACTION) study"were utilized and those of body mass index≥28 kg/m 2 were screened. The patients were divided into UACR normal group and UACR abnormal group(101 pairs) upon being matched on a 1∶1 basis by age and gender. Multivariate logistic regression analysis, receiver operating characteristic(ROC) curve, and restricted cubic spline(RCS)analysis were performed to explore the risk factors for abnormal UACR. Results:Compared with the normal UACR group, the UACR abnormal group had a higher number of alcohol consumers, a higher prevalence of hypertension, elevated systolic blood pressure, and triglyceride(all P<0.05). Multivariate logistic regression analysis showed that alcohol consumption( P=0.008), systolic blood pressure( P<0.001), triglyceride( P=0.049), and homeostasis model assessment for insulin resistance(HOMA-IR, P=0.033) were independent risk factors for abnormal UACR in obese people. The ROC curve analysis indicated that systolic blood pressure had the strongest diagnostic performance as a single factor(ROC curve area=0.801), and there was no significant difference in diagnostic performance compared to multiple factors combination. RCS analysis results showed that the probability of abnormal UACR increased monotonically with the increase of systolic blood pressure when the systolic blood pressure was between 130 and 158 mmHg(1 mmHg=0.133 kPa). When systolic blood pressure was not in the interval, the probability of abnormal UACR did not change significantly. The results of regression analysis of triglyceride subgroup showed that when triglyceride level was greater than or equal to 5.6 mmol/L, the risk of abnormal UACR level was significantly increased( P=0.029). Conclusion:Systolic blood pressure, triglyceride, HOMA-IR, and alcohol drinking history are independent risk factors for abnormal UACR in obese people. When systolic blood pressure is≥130 mmHg or triglyceride is≥5.6 mmol/L, the risk of abnormal UACR is significantly increased.
9.Research of Methods to Reduce Alarm Fatigue of Monitoring System.
Mengxing LIU ; Zehui SUN ; Wenyu YE ; Sanchao LIU ; Xianliang HE ; Cheng WANG ; Ye LI
Chinese Journal of Medical Instrumentation 2020;44(6):481-486
OBJECTIVE:
In order to solve alarm fatigue, the algorithm optimization strategies were researched to reduce false and worthless alarms.
METHODS:
A four-lead arrhythmia analysis algorithm, a multiparameter fusion analysis algorithm, an intelligent threshold reminder, a refractory period delay technique were proposed and tested with collected 28 679 alarms in multi-center study.
RESULTS:
The sampling survey indicate that the 80.8% of arrhythmia false alarms were reduced by the four-lead analysis, the 55.9% of arrhythmia and pulse false alarms were reduced by the multi-parameter fusion analysis, the 28.0% and 29.8% of clinical worthless alarms were reduced by the intelligent threshold and refractory period delay techniques respectively. Finally, the total quantity of alarms decreased to 12 724.
CONCLUSIONS
To increase the dimensionality of parametric analysis and control the alarm limits and delay time are conducive to reduce alarm fatigue in intensive care units.
Alert Fatigue, Health Personnel/prevention & control*
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Arrhythmias, Cardiac/diagnosis*
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Clinical Alarms
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Humans
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Intensive Care Units
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Monitoring, Physiologic
10.A Survey of Patient Monitoring Alarms in Cardiac Care Units.
Puping LIU ; Meng XU ; Huizhi WANG ; Hua PI ; Peiyi XIE ; Ye LI ; Mengxing LIU
Chinese Journal of Medical Instrumentation 2021;45(4):450-453
OBJECTIVE:
The patient monitors were used to explore the alarm fatigue in a cardiac care unit and to investigate the awareness and reaction of nurse to alarms.
METHODS:
A semi-structured survey was taken to acquire nurses' feeling and knowledge about monitoring alarm. Three full-time researchers were scheduled to track the alarms with annotations, and analyze the alarm data of 12 patient monitors using central monitoring system.
RESULTS:
A total of 72 310 unique alarms occurred in the 67-day study period. About 75.7% of them were physiological alarms and less than 10% of medium-low alarms were false positives. The average alarm rate was 128 alarms/patient-day.
CONCLUSIONS
There remains alarm fatigue in CCU, the alarm accuracy has improved than the past by applying new technologies. In some cases, clinicians will pay more attention to trend alarm and combination alarm.
Arrhythmias, Cardiac
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Clinical Alarms
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Electrocardiography
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Humans
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Monitoring, Physiologic
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Surveys and Questionnaires