Objective: To understand the status and related knowledge requirements of health emergency literacy among college students in Shaanxi Province, so as to provide the basis for improving college students health emergency literacy. Methods: A total of 2 723 students from 18 colleges and universities in Shaanxi Province were selected by multi stage random sampling and simple random sampling methods in November 2023, and the survey of health literacy in emergency and knowledge requirements of health emergency literacy was conducted. Statistical analysis was carried out by using χ 2 test, Wilcoxon rank sum test, Kruskal-Wallis H test and Logistic regression analysis. Results: About 28.98% of the surveyed college students had a high level of health emergency literacy, which varied by students whether being only one child, whether having left behind experience, with different personality types, whether being student cadres, and with different frequencies of community or social activities ( χ 2=9.15, 7.90, 32.73, 16.29 , 120.25, P <0.05). The equivalence scores of the four dimensions of health emergency literacy from high to low were poisoning and nuclear and radiation (0.84), medical rescue (0.83), infectious disease (0.82), and basic knowledge and behavior ( 0.77 ). Logistic regression analysis found that college students with left-behind experience were negatively correlated with health emergency literacy and its four dimensions ( OR =0.74, 0.72, 0.80, 0.80, 0.83), while personality type (rational type), community or social activity frequency were positively correlated with the cognitive levels of health emergency literacy and its four dimensions among college students ( OR =1.57, 1.50, 1.33, 1.27, 1.38)( P <0.05). There was a higher level of basic knowledge and behavioral cognition among only child college students ( OR =3.73), and female students had a higher level of health emergency literacy, as well as awareness of infectious disease outbreaks and medical rescue ( OR =1.21, 1.28, 1.21)( P <0.05). The radar map showed that the level of health emergency literacy was positive development radar map. About 67.68 % of the students had a high willingness to acquire health emergency literacy knowledge, and the demand for basic health emergency knowledge and behavioral knowledge was the highest (52.37%). Conclusions College students have insufficient health emergency literacy, but they have the highest demand for health emergency. Publicity and education should be strengthened for students with left behind experience, irrational type, and low frequency of community or social activities.

【Objective】 To explore the effect of UBE2I and FCGR1A gene expressions on the incidence of acquired immune deficiency syndrome (AIDS) combined with active pulmonary tuberculosis (APTB), so as to provide basis for disease monitoring. 【Methods】 A total of 98 AIDS patients combined with APTB and 84 AIDS patients combined with latent tuberculosis infection (LTBI) were selected from the validated whole genome transcriptome dataset (GSE37250). The top 30 differentially expressed genes (DEGs) in the two groups of patients were screened. We established the PPI interaction network, transcription factor-differentially expressed gene (TF-DEG), DEG-miRNA, and environmental chemical regulation network of the top 30 DEGs. Receiver operating characteristic (ROC) curves of 11 key DEGs were plotted and Logistic regression analysis was performed. 【Results】 There were 6 054 DEGs in the two groups of patients, and UBE2I was an important core node of the PPI interaction network. FCGR1A had the best predictive and indicative ability for AIDS combined with APTB. Univariate Logistic regression showed that high expressions of UBE2I and FCGR1A were risk factors for AIDS combined with APTB (P<0.05). The regulatory network showed that VEGFB was a key gene in the TF-DEG network, participating in regulation with transcription factors such as SEPT9 and SMAD5. It targeted miRNAs such as hsa-mir-17-5p and hsa-mir-20a-5p, and was affected by environmental chemicals such as valproic acid and copper sulfate. 【Conclusion】 VEGFB plays an important role in the pathogenesis of AIDS combined with APTB. The abnormally high expressions of UBE2I and FCGR1A are associated with the disease progression of AIDS combined with APTB. The disease condition can be monitored by detecting the expression level of UBE2I and FCGR1A.