Objective:To analyze the research hotspots and development frontiers of wearable devices in nursing at home and abroad.Methods:Relevant studies on the application of wearable devices in nursing published up to October 31, 2022 were retrieved from China National Knowledge Infrastructure, Wanfang Databases, and Web of Science Core Collection databases. CiteSpace 6.1.R6 was used to conduct visual analysis on the trend of publication, countries and institutions, keywords, et al.Results:A total of 373 articles were included, including 187 in English and 186 in Chinese. The overall number of published articles was on the rise. Foreign research hotspots included sports monitoring, health monitoring and so on, and the research objects were mainly adults. Domestic research hotspots mainly included smart elderly care, mobile medical care, telemedicine, etc., and the research objects were mainly the aged.Conclusions:At present, the research on wearable devices in nursing is generally scant, and the number of published papers is low, but the overall number of published papers is on the rise. In the future, it is necessary to further explore the appropriate population and scene of wearable devices in nursing, expand the depth and breadth of research on wearable devices in nursing, pay attention to multidisciplinary collaboration, keep up with policy and technological changes, so as to promote the further development of nursing cause.

Objective:To investigate the status of nursing practice and organizational management for reperfusion therapy in ischemic stroke across medical institutions in Beijing.Methods:In June 2023, a survey was conducted among nursing managers from 62 medical institutions under the jurisdiction of the Beijing Stroke Treatment Quality Control and Improvement Center. The survey aimed to assess the current nursing practices and organizational management for reperfusion therapy in ischemic stroke.Results:Among the 62 medical institutions, 16.13% (10/62) had dedicated reperfusion therapy nurses for stroke, and 87.10% (54/62) had established specific nursing protocols and procedures for stroke reperfusion therapy within their departments. However, 27.42% (17/62) of these institutions based the development and updates of their protocols on experiential summaries rather than standardized guidelines. In terms of nursing practice, there was room for improvement in emergency identification and triage of suspected stroke patients, assistance with intravenous thrombolysis, patient condition monitoring, early rehabilitation, and related health education. Regarding nursing quality control, significant differences were observed between institutions that regularly conducted quality control of stroke reperfusion therapy nursing and those that organized regular training sessions for nurses in this area ( P<0.05) . Conclusions:While nursing practices and quality for stroke reperfusion therapy in Beijing are progressing, there are disparities in regional development. There is a high demand for specialized stroke nursing and targeted technical training.

We recently reported an unconventional mechanism by which miRNAs inhibit HIV-1 viral production. This occurs when miRNAs bind nonspecifically to the viral structural protein Gag, interfering with viral RNA-mediated Gag assembly at the plasma membrane. Consequently, misassembled viral complexes are redirected into the endocytic pathway where they are delivered to lysosomes for degradation. In this study, we demonstrate that autophagy is a critical mediator of the viral degradation pathway and that this pathway is not HIV-1 specific. Misassembled viral complexes were found to colocalize extensively with LC3 and p62 in late endosomes/lysosomes, demonstrating a convergence of autophagy with functional degradative compartments. Knocking down autophagosome formation machineries reduced this convergence, while treatment with autophagy-inducer rapamycin enhanced the convergence. Furthermore, similar autophagy-dependent nonspecific miRNA inhibition of murine leukemia virus (MLV) assembly was shown. Overall, these results reveal autophagy as a crucial regulator of the retroviral degradation pathway in host cells initiated by nonspecific miRNA-Gag interactions. These findings could have significant implications for understanding how cells may regulate retroviral complex assembly by miRNA expression and autophagy, and raise the possibility that similar regulations can occur in other biological contexts.
Autophagy ; Cell Membrane ; metabolism ; Gene Products, gag ; genetics ; metabolism ; HEK293 Cells ; HIV-1 ; metabolism ; Humans ; Lysosomes ; metabolism ; MicroRNAs ; genetics ; metabolism ; Virus Assembly