1.A case of giant ovarian goiter, pleural effusion and peritoneal effusion with marked elevation of glycoantigen 125
Mengnan DING ; Linqing YANG ; Yuying ZHANG ; Jing XU
Clinical Medicine of China 2021;37(2):128-130
The incidence of struma ovarii(SO) is low, accounting for 5% to 15% of ovarian teratoma.Huge SO, pleural effusion and ascites with elevated carbohydrate antigen 125 are rare.There is no perfect clinical treatment guideline for the diagnosis and treatment of SO.MRI of patients with SO showed " Black Pearl" appearance.Appendectomy can be selected as the operation method.Postoperative pathology can confirm the diagnosis, and the prognosis is good.
2.Dietary preference and nutritional knowledge needs of the elderly at meal service sites in Shanghai
Hui ZOU ; Yang SU ; Xiaoli WU ; Mengnan WU ; Shaojun ZHANG ; Huahua DING ; Geng ZONG ; Zhenxing GE
Shanghai Journal of Preventive Medicine 2023;35(4):380-386
ObjectiveTo investigate the dietary preference and nutritional knowledge needs of the elderly people who dined at meal service sites. MethodsUsing the form of stratified and convenience sampling method with self-designed questionnaire was used, in November 2021, to select 700 elderly people who dine at meal service sites in 7 jurisdictions in Shanghai were selected, and a self-designed questionnaire was used to investigate the basic information. Results91.64% of the elderly surveyed would eat at relatively fixed meal service sites, and the total Dietary Diversity Score (DDS9) was 3.56±1.46. 41.45% of the elderly with diseases preferred unhealthy cooking methods. Only 8.03% of the surveyed seniors said they were unwilling to accept targeted and personalized nutrition tips and reminders. Multivariate logistic regression analysis showed that the probability reaching the “understanding” level of “Food Guide Pagoda for Chinese Residents” and “Four Principles Recommended by the Core Dietary Guidelines for the Elderly” was different in the elderly with different education levels. The willingness of the elderly to expect to receive different nutrition tips and reminders was related to whether they cared about the corresponding contents. There was a statistically significant difference (P<0.05) among the elderly who were concerned about different health problems in terms of the willingness to receive different nutritional tips. There were significant differences in the proportion of elderly people with different health status for intervention (χ2=5.402, P<0.05). ConclusionThe elderly who dine at meal service sites are highly dependent on the sites, have a low level of dietary diversification, and do not have a high degree of understanding of nutrition-related knowledge, and have a high demand for targeted nutritional interventions. Nutritional interventions for the sick elderly should be piloted through multiple channels.
3.Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis.
Mengnan ZHAO ; Rujing WANG ; Kunmeng YANG ; Yuhong JIANG ; Yachen PENG ; Yuke LI ; Zhen ZHANG ; Jianxun DING ; Sanjun SHI
Acta Pharmaceutica Sinica B 2023;13(3):916-941
RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of therapeutic RNA to the targeted location and precise detection of RNA markers remains challenging. Recently, more and more attention has been paid to applying nucleic acid nanoassemblies in diagnosing and treating. Due to the flexibility and deformability of nucleic acids, the nanoassemblies could be fabricated with different shapes and structures. With hybridization, nucleic acid nanoassemblies, including DNA and RNA nanostructures, can be applied to enhance RNA therapeutics and diagnosis. This review briefly introduces the construction and properties of different nucleic acid nanoassemblies and their applications for RNA therapy and diagnosis and makes further prospects for their development.
4.Potentiating CD8
Juanjuan YUAN ; Ting CAI ; Xiaojun ZHENG ; Yangzi REN ; Jingwen QI ; Xiaofei LU ; Huihui CHEN ; Huizhen LIN ; Zijie CHEN ; Mengnan LIU ; Shangwen HE ; Qijun CHEN ; Siyang FENG ; Yingjun WU ; Zhenhai ZHANG ; Yanqing DING ; Wei YANG
Protein & Cell 2021;12(4):240-260
Metabolic regulation has been proven to play a critical role in T cell antitumor immunity. However, cholesterol metabolism as a key component of this regulation remains largely unexplored. Herein, we found that the low-density lipoprotein receptor (LDLR), which has been previously identified as a transporter for cholesterol, plays a pivotal role in regulating CD8
5.Correction to: Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling.
Juanjuan YUAN ; Ting CAI ; Xiaojun ZHENG ; Yangzi REN ; Jingwen QI ; Xiaofei LU ; Huihui CHEN ; Huizhen LIN ; Zijie CHEN ; Mengnan LIU ; Shangwen HE ; Qijun CHEN ; Siyang FENG ; Yingjun WU ; Zhenhai ZHANG ; Yanqing DING ; Wei YANG
Protein & Cell 2022;13(9):694-700