1. Efficacy observation of thalidomide combined with TP regimen in treatment of advanced gastric cancer
Mengke NIU ; Wenying DENG ; Ning LI ; Suxia LUO
Cancer Research and Clinic 2019;31(9):610-613
Objective:
To analyze the clinical efficacy of thalidomide combined with TP regimen (taxol+cisplatin) in treatment of advanced gastric cancer.
Methods:
A total of 60 patients with advanced gastric cancer in the Affiliated Cancer Hospital of Zhengzhou University from February 2016 to March 2018 were enrolled. The patients were divided into two groups by using random number table method: the observation group (32 cases) taking thalidomide, oral administration 100 mg based on TP regimen before going to bed; the control group (28 cases) taking TP regimen chemotherapy only. Both groups received 75 mg/m2 doses of cisplatin, intravenous infusion, 25 mg/m2 per day, for 3 d. Paclitaxel dose was 150 mg/m2, intravenous infusion for 1 day, 3-week was one course, and the efficacy was evaluated after at least 2 course of treatment.
Results:
The incidence of gastrointestinal adverse reactions including nausea and vomiting was 21.8% (7/32) in the observation group, and was 64.3% (18/28) in the control group, and the difference was statistically significant (χ 2 = 11.051,
2. The clinical characteristic treatment strategy and prognosis of adenoid cystic carcinoma of the head and neck
Yan LI ; Wenying DENG ; Ning LI ; Mengke NIU ; Suxia LUO
Chinese Journal of Oncology 2019;41(12):932-936
Objective:
To explore the clinical characteristics, treatment strategy and prognosis of adenoid cystic carcinoma of the head and neck (ACCHN).
Methods:
A retrospective analysis of the clinical and follow-up treatment of 79 patients with ACCHN from June 2008 to July 2017 was conducted in the Cancer Hospital of Zhengzhou University.
Results:
A total of 79 ACCHN cases, including 31 males and 48 females. The age ranged from 19 to 77 (median, 52). The clinical manifestations of ACC were related to the locations of primary tumor.The mean size of the tumor was 2.6 cm (range from 1.5 to 7.7 cm). 50 of 79 patients with a definitive pathological diagnosis received surgical resection. 59 cases received chemotherapy and 62 cases received radiotherapy. With a median follow-up of 55 months, the 5-year, 10-year survival rate of these patients were 69.6% and 54.4%, respectively.
Conclusions
ACCHN is an uncommon neoplasm with the characteristics of epithelial nerve growth, being inclined to distant metastasis, and high early misdiagnosis rate. The clinical manifestation, imaging and pathological result are need to be combined together to diagnose ACCHN.
3.Current situation and advances in road transportation safety among children
LI Kuinan, NIU Yushuo, SUN Mengke, YU Pengli, HAN Xuena, YANG Xiuling
Chinese Journal of School Health 2021;42(6):950-955
Abstract
In China, road traffic injury has been the 2nd leading cause of death for minors aging from 1 to 14 years old, has become an urgent public health problem in China. This paper introduces the current situation of children s road traffic accident injuries. Based on Haddon s model, the influencing factors of children s road traffic safety are summarized into two aspects:individual and environmental levels. Also it puts forward targeted strategies for children road safety, including improving the relevant laws and regulations system, releasing commercial insurance into children CRS evaluation criteria, improving the safety awareness level of parents, strengthening the campus traffic safety education and optimizing the road safety protection facilities, all of which could contribute to protect child safety, thus providing reference for China to improve the road traffic safety education for children.