Attaching importance to the ideological and political education of medical students is an important experience and political advantage for the vigorous development of health undertakings under the leadership of the Communist Party of China (CPC). During the Yan’an period, the CPC put forward a series of theoretical principles and path methods to carry out the ideological and political education work for medical students, and formed a wealth of work experience. These were mainly manifested in the education direction of serving the Anti-Japanese War, the education content combining labor educational with ideological education, flexible and diverse educational methods, and the educational characteristics of education in medical ethics and medical style. In the new era and new journey, it is necessary to draw on the historical experience of ideological and political education work for medical students during the Yan’an period, cultivate a team of medical talents with both moral and talent, and provide strong and reliable talent support for high-quality development of the medical and health undertakings and a healthy China.