Objective To explore the clinical effect of mifepristone for emergency contraception. Methods All 379 re-productive age women who required emergency contraception were selected to give oral mifepristone and the contracep-tive effectiveness, the adverse reactions and the single impact factor,vaginal bleeding were observed and analyzed. Results The effective rate of mifepristone for emergency contraception was 79.02%,102 cases (26.9%) appeared ad-verse reactions,less than or equal to 30 years old and take drug by several times were the influence factors of adverse reactions, 22 cases (5.8%) appeared vaginal bleeding. Conclusion There is still possibility to appear pregnancy and ad-verse reactions with mifepristone for emergency contraception, we should be to do a good job of follow-up and treat-ment after taking the drugs.