Antimicrobial resistance poses a serious threat to public health and is one of the major challenges worldwide. As global social, economic, and environmental changes lead to increased exposure of populations to antimicrobials, the antimicrobial resistance of pathogens has accelerated and resulted in weakened clinical infection treatment effects. This article reviews the main mechanisms and driving factors of the production and spread of antimicrobial resistance from the perspective of "One Health"and discusses methods and strategies for controlling antimicrobial resistance from multiple dimensions. It also looks forward to the prospects of research and prevention of drug resistance to explore antimicrobial resistance prevention and control strategies based on "One Health".

Antimicrobial resistance poses a serious threat to public health and is one of the major challenges worldwide. As global social, economic, and environmental changes lead to increased exposure of populations to antimicrobials, the antimicrobial resistance of pathogens has accelerated and resulted in weakened clinical infection treatment effects. This article reviews the main mechanisms and driving factors of the production and spread of antimicrobial resistance from the perspective of "One Health"and discusses methods and strategies for controlling antimicrobial resistance from multiple dimensions. It also looks forward to the prospects of research and prevention of drug resistance to explore antimicrobial resistance prevention and control strategies based on "One Health".

OBJECTIVE： To provide reference for the coordinated development of the pharmaceutical manufacturing industry and regional economy in the central and western regions of China. METHODS： With reference to China High-tech Industry Statistical Yearbook in 2011-2017 and China Statistical Yearbook in 2011-2017， relevant data of 14 provinces （municipatities， automous regions） in the central and western regions during 2010-2016 were collected， and a comprehensive evaluation index system and coupling coordination model of pharmaceutical manufacturing industry and regional economy were constructed， and the coupling coordinated relationship between pharmaceutical manufacturing industry and regional economy in the central and western regions of China were analyzed. RESULTS & CONCLUSIONS： During 2010-2016， the comprehensive development level of the pharmaceutical manufacturing industry and the regional economy in the central and western was on the rise， but the growth rate was relatively slow； the provinces in the central region were better than the western provinces. There were obvious coupling characteristics between the pharmaceutical manufacturing system and the regional economic system， and the coupling coordination degree had an obvious upward trend in 2010-2016. Although there were fluctuations during the period， the fluctuation degree was small and the overall trend was rising. Among them， pharmaceutical manufacturing industry and regional economy of Shanxi， Guangxi， Yunnan and Xinjiang had the same degree of coupling and coordination， which showed that the coupling coordination degree of them were greatly affected by the development of pharmaceutical manufacturing industry； Inner Mongolia， Jiangxi， Henan， Hubei， Chongqing， Sichuan， Shaanxi and Gansu had same coupling coordination degree and fluctuation course of regional economic development， which showed that the coupling coordination degree of them was greatly influenced by the development of regional economy； Anhui and Hunan had same coupling coordination degree with the development of pharmaceutical manufacturing industry and regional economy. The development of their pharmaceutical manufacturing industry and regional economy were on the rise， which showed that they were both in the rising stage of development. The mutual promotion of pharmaceutical manufacturing industry and regional economy showed that their coupling coordination was also improving. It is suggested to speed up the adjustment of industrial structure， promote the industrial transfer； pay attention to talent education， improve the talent reserve mechanism； increase the investment in fixed assets， improve infrastructure construction in central and western regions； increase the per capita disposable income of residents， promote the development of regional econorny，so as to premote the coordinated development of pharmaceutical manufacturing industry and regional economy.