With global climate change, the frequency and intensity of extreme weather events have increased, and the possibility of multiple extreme weather events occurring simultaneously or continuously forming compound extreme events has also significantly increased, bringing catastrophic damage to the ecological environment, socio-economic and human health. This study reviewed the changing trends and health risks of consecutive compound heavy precipitation and heatwave extremes. There is currently no unified definition for these types of events, which could be divided into two subcategories: heavy precipitation-heatwave and heatwave-heavy precipitation. Their historical frequency and intensity have increased, and future estimates are also on the rise. The majority of current studies on single extreme events such as heatwaves or heavy precipitation revealed significant adverse health effects. However, few studies focused on the association between compound events of heavy precipitation and heatwave and human health risk. This paper further summarized the current shortcomings in this field and proposed suggestions for future research directions.

With global climate change, the frequency and intensity of extreme weather events have increased, and the possibility of multiple extreme weather events occurring simultaneously or continuously forming compound extreme events has also significantly increased, bringing catastrophic damage to the ecological environment, socio-economic and human health. This study reviewed the changing trends and health risks of consecutive compound heavy precipitation and heatwave extremes. There is currently no unified definition for these types of events, which could be divided into two subcategories: heavy precipitation-heatwave and heatwave-heavy precipitation. Their historical frequency and intensity have increased, and future estimates are also on the rise. The majority of current studies on single extreme events such as heatwaves or heavy precipitation revealed significant adverse health effects. However, few studies focused on the association between compound events of heavy precipitation and heatwave and human health risk. This paper further summarized the current shortcomings in this field and proposed suggestions for future research directions.

Objective To explore the mechanism underlying the anti-hemorrhoid effects of Qingji Liangxue mixture(QLM).Methods Models of acute hemorrhoid in rats were established using a croton oil preparation(COP)and glacial acetic acid.A total of 80 SD female rats were randomly divided into two major groups:the COP group and the glacial acetic acid group,each consisting of 40 rats.In the COP group,rats were further randomly assigned to the following subgroups:control group 1(group CA),model group 1(group CB),low-dose QLM group 1-1(group CC),high-dose QLM group 1-2(group CD),and diosmin group 1(group CE),with eight rats in each subgroup.In the glacial acetic acid group,rats were randomly divided into the following subgroups:control group 2(group GA),model group 2(group GB),low-dose QLM group 2-1(group GC),high-dose QLM group 2-2(group GD),and diosmin group 2(group GE),with eight rats in each subgroup.Except for the control groups,all other subgroups were treated with COP or glacial acetic acid then treated with various drugs for 7 days.HE staining was used to observe anorectal histomorphology induced by COP and glacial acetic acid.ELIS As were used to measure serum levels of IL-6 and TNF-α induced by COP.Additionally,the area of perianal ulcers induced by glacial acetic acid was recorded.Twenty-four C57 mice were randomly divided into a control group(group A),low-dose QLM group(group B),high-dose QLM group(group C),and adrenal chromazone tablet group(group D).Results QLM significantly improved the pathological injury of animal models with similar hemorrhoids,reduced the score of pathological changes induced by COP(P＜0.05),reduced the serum levels of IL-6 and TNF-α(P＜0.05),reduced the area of perianal ulcers induced by glacial acetic acid(P＜0.05),and shortened the time of coagulation and bleeding(P＜0.05).Conclusions QLM has a good anti-hemorrhoid activity,which may be achieved by anti-inflammatory effects,hemostasis,and reducing tissue damage.