Objective: To explore how to set up the service management center of ventilators depending on department of respiratory medicine , how to perfect daily management of ventilators, how to rationally and timely allocate ventilators ,how to reduce the fault of ventilators and ensure the safe use of ventilators, and how to cost savings of purchasing ventilators. Methods: To figure out and compare data of before and after the establishment of the service management center of ventilators in 2010 and in 2012. Results: Non machine failure rate was 42.86% in 2012 and 69.35% in 2010, had remarkably decreased. At the same time, the total failures have decreased significantly. Conclusion: Setting up the service management center of ventilators depending on department of respiratory medicine have achieved timely allocation ventilators, have improved the level of medical personnel of using ventilators, have ensured the safe use of ventilators, have cost savings of purchase ventilators, have reduced the fault of ventilators.

This article expounds the molecular biological characteristics and signaling pathw ay of Tol -like receptor 2 and investigates its advances in research on the roles of neuronal and blood brain barrier damage after cerebral ischemia.

Objective:To study CT and MRI radiological expression of benign and malignant meningiomas to provide a reliable evidence for clinical surgery scheme determination. Methods: The radiological and pathological data of 40 cases with meningiomas undergoing surgery in hospital were analyzed, and the benign and malignant lesions of meningiomas were judged according to imaging features such as meningioma shape, edge, signal or density, peritumorous edema, intratumorous calcification, multiple tumors, tumor brain interface status etc.Results: (1)Tumor signal or density: T1 signal inhomogeneous in 6 cases(15.0%), T2 signal inhomogeneous in 8 cases(20.0%), the signal homogeneous in 26 cases (65.0%), CT density is inhomogeneous in 15 cases(37.5%), CT density is homogeneous in 25 cases(62.5%); (2)Tumor edge: regular in 27 cases(67.5%), coarse, irregular, lobulated, with mural nodules in 13 cases(32.5%); (3)Dural tail sign in 36 cases (90.0%); (4)Skull invasion in 6 cases(15.0%); (5)Calcification within the tumor in 7 cases(17.5%); (6)Peritumoral edema in 14 cases(35.0%); (7)Multiple tumors in 6 cases(15.0%); (8)Enhance performance: Obvious homogeneous enhancement in 27 cases(67.5%), Obvious inhomogeneous enhancement in 13 cases(32.5%).Conclusion: Benign and malignant meningiomas with a certain radiological feature, the curative effect and prognosis may be properly evaluated by the radiological expression of meningiomas.

ObjectiveTo investigate the clinical efficacy of focused ultrasound for treating non-neoplastic epithelial disorders of vulvar. Methods212 patients with non-neoplastic epithelial disorders of vulvar were treated with focused ultrasound. The patients were followed up after the treatment,and symptom was observed and the efficacy was evaluated. ResultsThe efficacy of non - neoplastic epithelial disorders of vulvar of squamous hyperplasia,lichen sclerosus and mixed dystrophy was 99.2％, 100. 0％, 88.9％ respectively, the difference was not significat (P ＞ 0.05 ). The efficacy in different courses of patients was 100.0％ ( ＜ 2 years), 100.0％ (2 ～10 years) ,91.3％( ＞ 10 years) respectively,the difference was not significat( P ＞ 0.05). ConclusionFocused ultrasound was obviously effective in the treatment of patients with non-neoplastic epithelial disorders of vulvar.

ADAMs is a family of transmembrane proteins with multi domains and multiple functions,which play important roles in many(patho-)physiological processes.They are upregulated in a variety of tumors and possess protein shedding and adhesive activities,which showed that they could be useful as tumor biomarkers and promising targets for designing new anti-tumor drugs.This review focuses on the roles ADAMs play in the process of tumor development and the potential application in cancer therapy.

AIM: To explore if metabotropic glutamate receptors (mGluRs) i nduces neuroprotection against 6-hydroxydopamine (6-OHDA) neurotoxicity in PC1 2 cells. METHODS: The alteration of the glutamate in extracellul ar fluid of PC12 cells was detected by high performance liquid chromatography (H PLC) with a fluorescent detector. The cytotoxic activity of PC12 cells was assay ed by means of MTT colorimetric method. RESULTS: 6-OHDA dose-d ependently increased glutamate release and decreased cell activity of PC12 cells , and the mGluRs ligands had no significant effect on that. CONCLUSION: The mGluR3 ligands has no protective effect on neurotoxicity of PC12 cel ls induced by 6-OHDA.

Objective: To study stress distribution and displacement by different distract directioos on mandibular corpus with finite element method. Methods:A three-dimensional finite element model of mandibular distraction osteogenesis was established.Von Mises stress as well as the displac ement of gnathion and gonion under different loads were measured. Result s:The stress and displacement were positively related with distract forc e. Von Mises stress primarily accumulated in distracted areas and were higher un der bilateral distraction parallel to the occlusial plane. Gnathion and gonion w ere positively displaced on X and Z axes and negatively displaced on Y axis. Distraction parallel to the mandibular body induced positive displaceme nt of mandible on X and Y axes and negative on Z axis. Concl usion:Transversal displacement to the opposite side is greater during un ilateral distraction, while displacement on the saggittal plane is greater durin g bilateral distraction.

RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Although it is a short time since the discovery of the phenomenon, the technology develops fastly for the character of easy operation, low investment, specificity and potentiality, and researchers have made some progress on the mechanism of RNA interference and application in functional genomics and disease treatment. This article reviews the history, mechanism, biological significance and application of RNA interference.

Objective To observe the activation effect of histamine on mast cells in the acupoint area and its analgesic effects similar to acupuncture stimulation,so as to reveal the underlying mechanism of acupoint injection therapy.Methods A total of 60 SD rats were divided into control,model,normal saline(NS),histamine-injection and acupuncture groups(12 rats/group).Acute adjuvant-induced-arthritis(AIA) model was duplicated by injection of complete Freunds' Adjuvant(0.05 mL) into the left ankle articular cavity.For rats of saline and histamine groups,normal saline(50 ?L) and histamine(50 ?L,100 ?g/mL) were injected into the left "Zusanli"(ST 36) acupoint area.For rats of acupuncture group,manual acupuncture(lifting-thrusting and twisting needle intermittently) was applied to ST 36 for 20 min.Paw withdrawal(pain threshold,PT) was detected by radiant heat irradiation of the hindpaw.Skin and muscle tissues of ST 36 area were sampled to be fixed in formalin,then,sliced(5 ?m),and stained with Toluidine Blue,separately,followed by counting the degranulation rate of mast cells under microscope.Results Compared with normal control group and pre-modeling,PT of model,NS,acupuncture and histamine groups decreased significantly(P

Objective: To establish a determination method for the related substances in nortriptyline hydrochloride by HPLC. Methods:An Agilent C18 (250 mm × 4. 6 mm,5 μm) column was adopted with a mobile phase consisting of acetonitrile-0. 2% trieth-ylamine(pH 3. 0)(34 ∶66). The flow rate was 1. 0 ml·min-1, the detection wavelength was set at 210 nm, the column temperature was 40℃ and the injection volume was 20 μl. Results:The resolutions of the related substances were acceptable. The detection limit and the quantitation limit of the samples was 0. 40 ng and 1. 35 ng, respectively. Conclusion: The method is sensitive, accurate and specific, and can be used to determine the related substances in nortriptyline hydrochloride.