Adolescent ; Adult ; Barotrauma ; complications ; Female ; Humans ; Male ; Middle Aged ; Occupational Diseases ; etiology ; therapy ; Sinusitis ; etiology ; therapy ; Young Adult

OBJECTIVE To explore the causes, predilection sites and treatment of nasal sinus mucoceles after hypophysectomy.METHODS The clinical data of 7 cases with nasal sinus mucoceles after hypophysectomy diagnosed and treated in our Department from Jan.1998 to Aug.2007 were retrospectively studied.RESULTS The mucoceles were located at ethmoid sinus in 2 cases,frontal sinus in 2 cases,frontal and ethmoid sinuses in 3 cases.All of the 7 cases underwent mucocelectomy under nasal endoscope or a combined endoscopic intranasal and extra-nasal approach.No recurrence was found after follow up for 1 to 3 years.CONCLUSION The causes of nasal sinus mucoceles after hypophysectomy are the change of the anatomic structure of nasal cavity after surgery.The stenosis,adhesion of middle nasal meatus or obstruction of the sinus ostium are found in all the patients.Intranasal endoscopic surgery or combined with extra-nasal approach is the first choice for nasal sinus mucoceles.

Costimulatory signals have become a hot field in immunological researches. As co-inhibitory molecules, programmed death-1 ( PD-1) and its ligands (PD-1/PD-L) have been demonstrated to play an important role in autoimmune disease, organ transplant rejection, microorganism infection, tumor immune escapes etc. . In recent years,some studies about PD-1/PD-L pathway in ophthalmology have been curried out and reported. Some changes were found in PD-1/PD-L pathway, such as ocular immunologic diseases, ocular infectious diseases, ocular tumors, immune privilege in ocular tissues and so on. Through the research on PD-1/PD-L pathway,we can further understand the pathogenesis of some ocular diseases and find new methods for their prevention and treatments. This article reviewed the recent advances in PD-1/PD-L pathway in ophthalmological physiopathology.

Objective:To analyze the financial auditing method after changing the settlement method of outpatient medical income in hospitals under the background of launching “Jing Yi Tong” business line in public hospitals of Beijing.Methods:It summarized the key point of financing audit in outpatient medical income of hospitals under the settlement mode of “Jing Yi Tong”business,proposed the effective settlement method and suggestions on auditing.Results:Through close financial auditing,it effectively ensure the acuteness and completeness of outpatient medical income of hospitals,prevent the leak and man-made fraud in settlement process.Conclusion:The effective hospital financing audit was the main task for internal control,which played key role on improving hospital financing management level.

Objective: To investigate the 18F-FDG PET myocardial scintigraphy and Coronary CT angiography (CTA) combination improve coronary heart disease clinical diagnosis level, and the diagnosis of coronary heart disease treatment technology of standardization for clinical application. Methods:The use of positron radionuclide drug 18F-fluorodeoxyglucose (18F-FDG) was made in 35 patients with myocardial metabolic imaging of coronary arteries and CTA examination, 20 patients with myocardial infarction patients, the FDG PET myocardial scintigraphy and coronary artery CTA combine examination results and confirmed case comparison of results. Results: 18F-FDG PETmyocardial scintigraphy and coronary artery CTA combination in the diagnosis of coronary heart disease, sensitivity and specificity of 100%and 96%. Conclusion: 18F-FDG PET data and coronary artery CTA precision data fusion, the fusion image is accurate, can not only provide clinicians reflect coronary artery anatomy indicators, can also provide reflect myocardial pathological physiology and metabolism index, to verify and supplement each other between the indicators.

Objective To discuss the prevention and management of complications of transurethral electrovaporization of the prostate(TUVP).Methods A total of 820 patients underwent TUVP from June 1998 to August 2005.A Wolf electrovaporization system and a F_(24) 12? resectoscope were used.After the seminal colliculus was identified for making a reference plane,the prostatic tissues were removed untill the surgical envelope,and the bladder neck and the apex of prostate were surgically shaped.Results Complications occurred in 124 patients(15.1%,124/820).There were 17 cases of intraoperative complications(2.0%),including massive haemorrhage in 6 patients(0.7%),presymptoms of transurethral resection syndrome in 6 patients(0.7%),and perforation on the juncture of the bladder and the prostate in 5 patients(0.6%).There were 107 cases of postoperative complications(13.0%), including urethral stricture in 18 patients(2.2%),spasm of the bladder in 32 patients(3.9%),secondary hemorrhage in 3 patients(0.4%),retrograde ejaculation in 11 patients(1.3%),temporary incontinence in 13 patients(1.6%),infection of the urinary tract in 24 patients(2.9%),and acute pulmonary thromboembolism in 6 patients(0.7%). Conclusions Preoperative precautions and clear intraoperative exposure are essential to prevent the incidence of complications of TUVP.

Objective To explore the consistency of chemiluminescence microparticle immunoassay(CMIA)reagent and particle‐enhanced turbidimetric immunoassay(PETIA) reagent for detecting pepsinogen(PG) ,so as to provide laboratory references for en‐suring the reliability of PETIA reagent in detecting PG .Methods According to the requirement of EP9‐A2 file made by the Nation‐al Committee for Clinical Laboratory Standards(NCCLS) ,taking PETIA as evaluating method and CMIA as reference method ,a to‐tal of 92 specimens collected from patients with various degrees of gastric atrophy were selected ,PETIA and CMIA reagents were utilized for bidirectional detection of PG .Then recorded test results of pepsinogenⅠ(PGⅠ) ,and PGⅠ /pepsinogenⅡ(PG Ⅱ) rati‐o ,and carried out method comparison and bias evaluation for the two kinds of reagents .Results The expected relative bias of detec‐tion results of PGⅠ and PGⅠ /PG Ⅱ ratio by using PETIA and CMIA reagents were acceptable within linear range of methods . Conclusion The results of PGⅠ and PG Ⅱ detected by using PETIA reagent could be accepted .

There are some risk points in the management process of enterprises-funded research project,such as verification of the qualification of the client,the audit of the contract,the report of the research results,and the protection of intellectual property.This paper puts forward the management mode of the research project,which is based on the contract management,strengthen the management of enterprises-funded research project from every processes the contract develop,sign,fulfill and delivery.

Computer programming courses is generally considered as the most difficult courses to understand and study.We have carried out some reforms in teaching experiment:making learning objective clearer to stimulate students' learning desire;adjusting teaching content to enhance the students' learning interest;combining teachers'accessible elucidation with students' operation in the class to improve both the teaching effect and students' comprehensive application capability.

BACKGROUND: Theoretically, a novel single-sided groove target release biodegradable stent can avoid drug-induced inflammation of the local vessel wall, reduce drug dose, decrease the likelihood of thrombosis, and relieve stenosis.OBJECTIVE: To evaluate the influence of the novel single-sided groove target release biodegradable stent on intimal hyperplasia in a healthy porcine coronary artery model.METHODS: Eighteen healthy pigs were randomly divided into three groups, bare metal stent group, Firebird metal stent group and Firehawk stent group, which were implanted with L605 cobalt chromium alloy bare metal stents and L605 cobalt chromium alloy non-biodegradable rapamycin-eluting stent and L605 cobalt chromium alloy biodegradable rapamycin-eluting stent, respectively. Two same stents were implanted into the left anterior descending artery and the right coronary artery of each pig, respectively. After 1 and 3 months of follow-up, coronary angiography was performed,and the pigs were killed to take coronary artery samples for detection of intima hyperplasia.RESULTS AND CONCLUSION: At 1 and 3 months after stent implantation, no stenosis, thrombosis and aneurysm occurred in the three groups shown by the coronary angiography; the lumen loss was significantly lower in the Firebird metal stent group and Firehawk stent group than the bare metal stent group (P < 0.05), while there was no difference between the Firebird metal stent group and Firehawk stent group. Histopatologically, there was no coronary arterial tissue necrosis or luminal thrombosis in the three groups. Compared with the bare metal stent group, at 1 and 3 months after stent implantation, the neointimal area and the percentage of stenosis were significantly lower in the Firebird metal stent group and Firehawk stent group (P < 0.05), while the residual lumen area and internal elastic lamina area were significantly higher (P < 0.05). Additionally, there was no significant difference between the Firebird metal stent group and Firehawk stent group. Overall, the Firehawk stent that achieves the same clinical efficacy as the non-biodegradable rapamycin-eluting stent effectively inhibits intimal hyperplasia, and prevents stent restenosis after stent implantation.However, future investigations on the long-term effect are warranted.