1.Therapeutic effect of co-administration of simvastatin,clopidogrel and low molecular weight heparin on patients with unstable angina pectoris
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2014;(3):215-218
Objective To approach the effects of the combination of simvastatin,clopidogrel and low molecular weight heparin on patients with unstable angina pectoris(UAP). Methods A total of 86 patients presented with UAP in Department of Internal Medicine of Tianjin Hongqiao Hospital were divided into control group and therapy group(each 43 cases)by random number table. The patients in the control group were treated with routine therapies such as oxygen,anti-platelet agents,nitrates,β-blockers,calcium channel antagonists,et al,while the patients in treatment group received besides the above conventional treatments,they additionally took simvastatin, clopidogrel orally and subcutaneous injection of low molecular weight heparin. The frequency of recurrence of angina, improvement of cardiac ischemia,the change of cholesterol,adverse reaction and the occurrence of complication were observed during 4 weeks of treatment. Results Compared to the control group,the frequency of angina(time/week:2.77±1.12 vs. 3.78±2.57,P<0.05)and consumption of nitroglycerin(mg/d:1.16±0.46 vs. 2.89±1.89,P<0.05) were obviously less,the improvement of cardiac ischemia(95.3%vs. 79.1%,P<0.05)and electrocardiogram(ECG:90.7%vs. 62.8%,P<0.05)was superior and the total effective rate was higher obviously in the therapy group. After treatment,plasma cholesterol levels were decreased obviously in treatment groups compared with before treatment (mmol/L:3.78±1.23 vs. 5.76±1.74,P<0.05),but the statististical difference in cholesterol levels in control group was found between before and after treatment(5.66±1.14 vs. 5.69±1.89,P>0.05). Before and after treatment,there were no significant changes of platelet count(PLT),activated partial thromboplastin time(APTT),liver functions and renal functions,and after treatment,bleeding and allergy serious adverse reactions were not seen in patients of both groups. Myocardial infarction occurred in 2 patients in the control group. Conclusion The addition of combined application of simvastatin,clopidogrel and low molecular weight heparin onto routine therapies has better effects for treatment of UAP.
2.Application Analysis of Antitumor Chinese Herbal Injections of 32 Hospitals in Wuhan Area During 2010-2012
China Pharmacist 2014;(2):287-290
Objective: To investigate the current situation of consumption and development tendency of antitumor Chinese herbal injections in Wuhan area. Methods:The analytical method of the defined daily dose ( DDD) recommended by WHO was used to ana-lyze the application of antitumor Chinese herbal injections in 32 hospitals of Wuhan area during the period of 2010-2012. Results:The consumption sum and the DDDs of antitumor Chinese herbal injections were increased year after year, while the daily drug cost ( DDC) was stable in general. The sort of consumption was generally in accordance with the sequence of DDDs. Conclusion:The status quo of antitumor Chinese herbal injections during the period of 2010-2012 is in line with the characteristics of clinical application, indicating the use is rational.
3.Effects of C-peptide on apoptosis induced by hyperglycemia and the relationship between the apoptosis and the expression of eNOS in human umbilical vein endothelial cell (HUVEC)
Chinese Journal of Diabetes 2005;13(4):293-295
Objective To investigate the effects of C-peptide on apoptosis induced by high glucose and analyze the relationship between the apoptosis and expression of eNOS in HUVEC. Methods We determined the HUVEC apoptosis by Annexin-V, the expression of eNOS mRNA of HUVEC by RT-PCR, the apoptotic quantity of HUVEC by DNA fragment ELISA. Results High level of glucose could increase HUVEC apoptosis (P<0.01) and reduce the expression of eNOS. After adding physiological or high concentration of C-peptide, the apoptosis decreased and the expressions of eNOS increased markedly, with the relationship coefficient of -0.854 (P<0.01). Conclusion High glucose may induce apoptosis. Physiological or high concentration of C-peptide may reduce the apoptosis induced by hyperglycemia, the relationship between apoptosis and eNOS is negative.
4.Signaling pathways regulating autophagy after cerebral ischemia
International Journal of Cerebrovascular Diseases 2015;(9):715-719,720
A lot of evidence shows that autophagy is involved in the occurrence and development of cerebral ischemia - reperfusion. Autophagy and its related signal transduction pathways may be an effective therapeutic target for ischemic brain injury. This article reviews related signal transduction pathways of autophagy regulation after cerebral ischemia.
5.Classification of symptoms and signs in clinical term system of traditional Chinese medicine
Chinese Journal of Medical Library and Information Science 2015;24(10):77-80
After the concept of symptoms in traditional Chinese medicine was defined, the classification of symp-toms in traditional Chinese medicine and the characteristics of clinical diagnosis and treatment in traditional Chinese medicine were described .It was suggested that the symptoms in traditional Chinese medicine should be classified into 3 kinds, namely symptoms and signs according to the 4 diagnostic methods, symptoms and signs according to the diagnostic devices, symptoms and signs according to the physical constitutions of patients in order to lay a foun-dation for improving the classification in clinical term system of traditional Chinese medicine.
9.Study on the correlation between the expressions of cyclooxygenase-2 and p53 in human colorectal carcinoma
Dong MENG ; Jianping HANG ; Weili WANG
Cancer Research and Clinic 2000;0(06):-
Objective To investigate the expressions of COX-2 and p53 in human colorectal carcinoma and their correlations with clinicopathological features of colorectal carcinoma. Methods The expressions of COX-2 and p53 were determined by immunohistochemical staining in 72 surgical specimens of colorectal carcinoma and 21 normal mucosal tissues. Results The positive rates of COX-2 and p53 in colorectal carcinoma were 70.8 % and 62.5 %, respectively. The differences between carcinoma group and normal tissues group were statistically significant(P
10.Study of the estimating method for setting the criteria for hospital bed allocation in Shandong Province
Lingzhong XU ; Qingyue MENG ; Shushan DONG
Chinese Journal of Hospital Administration 1996;0(02):-
Objective To provide the administrative departments in the health sector with a method for estimating hospital beds when making regional health plans. Methods The method of general surveys was adopted to make relevant investigation on all the cities and districts in Shandong Province. Data collected were estimated by borrowed and self-developed formulas. Results By 2005, the total number of hospital beds in the province will be reduced by 5.19%, the number of beds in the city seats will be reduced by 4.97%, the number of beds in the county seats will be reduced by 1.03%, and the number of beds in the township seats will be reduced by 9.68%. Conclusion The findings of the study have filled in a gap at present when there is a lack of estimating methods. They are viable and yet still need to be polularized and perfected in practice.