OBJECTIVES: The purpose of this study was to investigate the effects of cognitive differentation training of Integrated Psychological Therapy(a training program of executive function,concept formation,language,and abstraction) on micro-level cognitive function such as attention,memory and reaction time in patients with schizophrenia. METHODS: Twenty-four inpatients diagnosed as schizophrenia using DSM-lV were randomly assigned to 2 group. The training group went through a total of 12 sessions of cognitive differentiation training for 4 weeks. The control group received psychoeducation Timer of Vienna Test System were administered to all patients, both before and after the training program. RESULTS: 1) In the attention and concentration scores of Wechsler Memory Scale-Revised, between group, within group and interaction effects of training were not significant. 2) In the short-term memory scores of Wechsler Memory Scale-Revised, within group effect of training was significant(F(1,24)=15.09,p<0.05), but the between group and interaction effects did not reach significance. 3) In the long-term memory scores of Wechsler Memory Scale-Revised, within group effect of training was significant(F(1,24)=15.09,p<0.05), but the between group and interaction effects did not reach significance. 4) In the reaction time scores of Decision-Reaction Timer,interaction effect of training was significant(F(1,24)=5.18,p<0.05). 5) In the motor time scores of Decision-Reaction Timer,between group,within group and interaction effects of training were not significant. 6) In the decision time scores of Decision-Reaction Timer,interaction effect of training was significant(F(1,24)=6.00,p<0.05). CONCLUSION: Our findings suggest that cognitive differentiation training of Integrated Psychological Therapy is partly effective on improving micro-level cognitive functions such as reaction time(especially,decision time)in patients with schizophrenia.
Education ; Humans ; Inpatients ; Memory ; Memory, Long-Term ; Memory, Short-Term ; Reaction Time ; Schizophrenia

This paper reviewed models to explain memory and neuropsychological tests to assess memory. Memory was explained in cognitive and neuroanatomical perspectives, Cognitive model describes memory as structure and process. In structure model, memory is divided into three systems: sensory memory, short-term memory(working memory), and long-term memory. In process model, there are broadly three categories of memory process: encoding, storage, and retrieval. Memory process work in memory structure. There are two prominent models of the neuroanatomy of memory, derived from the work of Mishkin and Appenzeller and that of Squire and Zola-Morgan. These two models art the most useful for the clinician in part because they take into account the connections between the limbic and frontal cortical regions, The major difference between the two models concerns the role of the amygdala in memory processess. Mishkin and his colleagues believe that the amygdala plays a significant role while Squire and his colleagues do not, The most popular and widely used tests of memory ability such as WMS-R, AVLT, CVLT, RBMT, CFT, and BVRT-R, were reviewed.
Amygdala ; Memory* ; Memory, Long-Term ; Memory, Short-Term ; Neuroanatomy ; Neuropsychological Tests ; Neuropsychology*

OBJECTIVES: The purpose of this study is to investigate the characteristics of memory disturbance caused by traumatic brain injury. METHODS: We measured the memory functions of 90 patients who complained of memory impairment after traumatic brain injury and were referred for mental disability evaluation, using Rey-Kim Memory Test. The patients were divided into three groups according to Memory Quotient and brain imaging studies. We also examined their intelligence and emotional characteristics using K-WAIS and MMPI. RESULTS: 1) Among the patients who complained of memory impairment and had abnormal brain imaging after traumatic brain injury, more than half showed no actual memory disturbance. 2) The group with actual memory disturbance showed normal verbal short-term memory but showed deficits in verbal long-term memory. And their visuospatial functions were preserved but visual short- and long-term memory were impaired. 3) There was notable correlation between memory function and intelligence in patients with traumatic brain injury. 4) The group with abnormal brain imaging showed more social withdrawal than the group without abnormal brain imaging. The group without abnormal brain imaging showed more somatization than the group with abnormal brain imaging. CONCLUSION: We suggest the special memory function test as well as brain imaging studies for patients who complain of memory impairment after traumatic brain injury.
Brain Injuries* ; Disability Evaluation ; Humans ; Intelligence ; Memory* ; Memory, Long-Term ; Memory, Short-Term ; MMPI ; Neuroimaging

OBJECTIVE: This study aimed to identify the core symptoms of delirium, particularly in elderly people associated with major risk factors, using the Korean version of the Delirium Rating Scale-Revised-98. METHODS: The study sample consisted of 200 patients (mean age: 72.7±3.9 years, male: 68.5%) who had been diagnosed with delirium. Exploratory factor analysis was used to investigate the factor structure, and confirmatory factor analysis was used to evaluate the goodness of fit of the results. RESULTS: The results demonstrated three core domains of delirium in the elderly patients: 1) the cognitive domain (e.g., language, thought process, orientation, attention, long-term memory, and visuospatial ability); 2) the circadian domain (e.g., sleep-wake cycle and motor behavior); and 3) the short-term memory domain (short-term memory). These results were confirmed by confirmatory factor analysis. CONCLUSION: The findings of this study suggest a theoretical domain structure for delirium in elderly patients.
Aged* ; Delirium* ; Factor Analysis, Statistical* ; Humans ; Male ; Memory, Long-Term ; Memory, Short-Term ; Risk Factors

Visual memory, mainly composed of visual long-term memory (VLTM) and visual working memory (VWM), is an important mechanism of human information storage. Since Baddeley proposed the multicomponent working memory model, the idea that VWM is independent of the VLTM system has been widely accepted. However, the new theoretical evidence suggested a close connection between VLTM and VWM. For instance, the three embedded components model describes the VLTM and VWM in the same framework, which suggests that VWM is only a distinct state of VLTM. On the one hand, the operating function of VWM is supported by the persistence of VLTM. On the other hand, the evidence from neuroimaging studies shows that VWM and VLTM tasks activate some same brain areas. In addition, the whole visual memory system shows a trend of processing from early visual cortex to prefrontal cortex. The present article not only reviews the current studies about the relationship between VLTM and VWM but also gives some forecasts for future studies.
Brain ; physiology ; Humans ; Memory, Long-Term ; Memory, Short-Term ; Visual Cortex ; physiology ; Visual Perception

OBJECTIVES: To investigate the relationship between cognitive functions and death in the elderly. METHOD: The MMSEK was administered to a community elderly population aged 65 or more. The initial MMSEK score and age were compared between the 6-yr survivors and 6-yr decedents. Relative risks of death were calculated in terms of sex, age, and educational level. RESULTS: The decedents were older and poorer in MMSEK performances except for orientation in place. The relative risk of death was 1.08 in the persons with questionable cognitive impairment and 1.94 in the persons with definite impairment. It was 1.13 in the illiterates and 1.26 in the educated. CONCLUSIONS:In the elderly the prospective survival and death may be related to severe cognitive decline, male sex, and old age, but not to mild cognitive decline, educational level, and remote memory.
Aged* ; Cognition ; Humans ; Male ; Memory, Long-Term ; Survivors

Memory is one of the most important mental mechanisms which is crucial for us to adapt to environmental surroundings and to maintain our identity. The neurobiological mechanisms for memory are based upon the synaptic plasticity that involve both functional and structural changes at the synapses in the neural circuits participating in learning and memory. Memory is not a single process but has two forms of short-term and long-term memory that are two independent but overlapping processes that blend into one another. The short-term memory depends upon the functional change of synaptic strength but the long-term memory requires anatomic changes of synapses in the neural circuit. Memory storage seems to use elements of a common genetic switch, involving cyclic adenosine monophospate (cAMP)-dependent protein kinase, mitogen activated protein kinase, and cAMP response element-binding protein, to convert short-term memory into long-term memory.
Adenosine ; Cyclic AMP Response Element-Binding Protein ; Learning ; Memory* ; Memory, Long-Term ; Memory, Short-Term ; Plastics ; Protein Kinases ; Synapses

OBJECTIVE: This study was conducted in order to evaluate the cognitive function of the elderly and to delineate the effects of sex, age and education on cognitive function. METHODS: The Cognitive Impairment Diagnosing Instrument(CIDI) was administered to the residents aged 70 years or more in Jookjang-Myun, Pohang City, Kyungpook. RESULTS: Mean percent decline were different among the CIDI subtests: concentration/calculation showed the greatest deterioration, performances on abstract thinking, higher cortical functions, and orientation in time declined by 20.3 to 29.5%, and long-term memory, memory registration, judgement object naming, and orientation in place showed modest decline. Performances on all the CIDI subtests were significantly correlated with age with correlation coefficients between -0.262 and -0.477. All subtest, but for short-term memory, scores were shown to be affected by education. Men scored better than women on all the CIDI subtests except for short-term memory and memory registration. CONCLUSION: All total and subtest performances of the CIDI were shown to be affected by sex, age, and education. However, memory registration and short-term memory revealed different pattern of decline according to the demographic factors.
Aged* ; Cognition ; Demography ; Education ; Female ; Gyeongsangbuk-do ; Humans ; Male ; Memory ; Memory, Long-Term ; Memory, Short-Term ; Rural Population* ; Thinking

Aquaporin-4 (AQP-4) is the predominant water channel in the central nervous system (CNS) and primarily expressed in astrocytes. Astrocytes have been generally believed to play important roles in regulating synaptic plasticity and information processing. However, the role of AQP-4 in regulating synaptic plasticity, learning and memory, cognitive function is only beginning to be investigated. It is well known that synaptic plasticity is the prime candidate for mediating of learning and memory. Long term potentiation (LTP) and long term depression (LTD) are two forms of synaptic plasticity, and they share some but not all the properties and mechanisms. Hippocampus is a part of limbic system that is particularly important in regulation of learning and memory. This article is to review some research progresses of the function of AQP-4 in synaptic plasticity, learning and memory, and propose the possible role of AQP-4 as a new target in the treatment of cognitive dysfunction.
Animals ; Aquaporin 4 ; physiology ; Hippocampus ; physiology ; Humans ; Learning ; Long-Term Potentiation ; Long-Term Synaptic Depression ; Memory ; Neuronal Plasticity

Long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission are forms of synaptic plasticity that have been studied extensively and are thought to contribute to learning and memory. The reversal of LTP, known as depotentiation (DP) has received far less attention however, and its role in behavior is also far from clear. Recently, deficits in depotentiation have been observed in models of schizophrenia, suggesting that a greater understanding of this form of synaptic plasticity may help reveal the physiological alterations that underlie symptoms experienced by patients. This review therefore seeks to summarize the current state of knowledge on DP, and then put the deficits in DP in models of disease into this context.
Depression ; Humans ; Learning ; Long-Term Potentiation ; Long-Term Synaptic Depression ; Memory ; Neuronal Plasticity ; Plastics ; Schizophrenia ; Synaptic Transmission