The ultrastructural alterations in rat liver by feeding NHM(nitrosohexamethylenemine). These are described at intervals of 10 days, 5 weeks, 11 weeks, 14 weeks, 19 weeks, and 22 weeks. The group at 5 and 11 weeks showed hyperplastic lesions but, no nuclear change. There were dilated rough endoplasmic reticulum with detached ribosomes, and alteration of mitochondria. The mitochondria showed a dense matrix which often included membranous materials. In the l4, 19, and 22 week groups, it showed nodular lesion which had atypical cells, and it was observed that the nucleus were enlarged and nucleoli were segregated. The bile canaliculi were dilated and contained dense materials.
Animal ; Female ; Liver/drug effects* ; Liver/pathology ; Methenamine/pharmacology* ; Microscopy, Electron ; Mitochondria, Liver/drug effects ; Nitrosamines/pharmacology ; Nitroso Compounds/pharmacology* ; Rats