The diagnosis of nodular melanomas can be sometimes difficult, in case they lack the conventional clinical features of melanoma. Herein, we report a case of malignant melanoma mimicking seborrheic keratosis. The clinical diagnosis was seborrheic keratosis. The histopathologic examination revealed nodular melanoma with features of reticulated form of epidermal hyperplasia, pseudohorn cysts, and irregular hyperkeratosis and acanthosis. The tumor was excised with 2.5 cm margins and no remnant of tumor cells was found in the microscopic examination.
Diagnosis ; Hyperplasia ; Keratosis, Seborrheic* ; Melanoma*

Pigmented mammary Paget disease is a very rare clinicopathologic variant of mammary Paget disease. Diagnosis is often difficult because its clinical and histological features are very similar to those of malignant melanoma. Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma.
Diagnosis ; Melanoma* ; Paget's Disease, Mammary*

Omphalith is a compaction of keratinous and sebaceous material in the deeply set umbilicus. It may be clinically mistaken for a malignant melanoma because of its pigmented surface and sudden appearance. However, careful probing and removal of this umbilical mass, followed by histopathological examination readily identifies its true nature. We describe a patient who presented with a firm, black umbilical mass diagnosed as an omphalith and reviewed the differential diagnosis of a firm, black umbilical mass.
Diagnosis, Differential ; Humans ; Melanoma ; Umbilicus

We report a rare case of vaginal amelanotic melanoma. Malignant melanomas are cutaneous and extracutaneous tumors that arise from embryological remnants of neural crest cells/melanocytes. Amelanotic melanomas at such rare locations can be misdiagnosed both clinically and radiologically. Therefore, histopathological examination and immunohistochemistry are mandatory for the diagnosis of these tumors. We diagnosed this case using histopathology and confirmed the diagnosis based on the presence of immunohistochemical markers human melanoma black 45 (HMB45) and S-100.
Diagnosis ; Humans ; Immunohistochemistry* ; Melanoma ; Melanoma, Amelanotic* ; Neural Crest ; Vagina

A case of znelanotic whitlow is presented which resembles clinically as chronic paronichia. Patient was 71 years old man and he has had a single brownish pigmented spot on left mid. finger since 3 years ago which was progressively grow and skin biopsy could be established the pathological diagnosis of superficial malignant melanoma.
Aged ; Biopsy ; Diagnosis ; Fingers ; Humans ; Melanoma ; Skin

Primary malignant melanoma of the esophagus is extremely rare, with less than 200 cases reported in the literature. However, primary malignant melanoma is an aggressive tumor. We report a case of primary esophageal malignant melanoma that presented with a large polypoid mass in the lower esophagus, and subsequently showed multiple metastatic nodules in the subcutaneous layer, skin and retroperitoneum. Primary malignant melanoma should be included in the differential diagnosis of a polypoid esophageal mass, especially in cases where metastases to unexpected areas occur or in cases of unexpected metastatic patterns.
Diagnosis, Differential ; Esophagus* ; Melanoma* ; Neoplasm Metastasis ; Skin

The authors have experienced a case of extrascleral extension of choroidal malignant melanoma. The patient has suffered from the ocular pain and proptosis of right eye. We performed Kronlein operation under the clinical impression of the retrobulbar mass and obtained the histopathological diagnosis of malignant melanoma. Fifteen days after the operation, we performed exenteration and the rotation flap of temporalis muscle was inserted into the right eye ball socket through the lateral wall of the orbit.
Choroid* ; Diagnosis ; Exophthalmos ; Humans ; Melanoma* ; Orbit

BACKGROUND: MART-1(melanoma antigen recognized by T cell) is a well-known marker for malignant melanoma. Its immunoreactivity is also expressed in other melanocytic lineage. OBJECTIVE: Our purpose is to evaluate the usefulness of MART-1 in the diagnosis of malignant melanoma. METHODS: MART-1 immunostaining was performed in 26 cases of malignant melanoma and 12 cases of benign melanocytic nevi. HMB-45 immunostaining was performed in 26 cases of malignant melanoma. RESULTS: 1. Eighteen of 26 melanomas(69%) and 10 of 12 benign melanocytic nevi(83%) showed reactivity with MART-1. 2. HMB-45 showed a higher sensitivity(85%) than that of MART-1 in the staining of malignant melanoma. 3. Two of 5 HMB-45-negative melanomas were immunoreactive with MART-1, and 2 of 7 MART-1-negative melanomas were reactive with HMB-45. CONCLUSION:MART-1 immunostaining is not helpful to differentiate malignant melanoma from benign melanocytic nevi. MART-1 was immunoreactive to some cases of HMB-45 negative malignant melanoma. MART-1, together with S-100 protein and HMB-45, is another useful marker of malignant melanoma.
Diagnosis ; Melanoma* ; Nevus, Pigmented* ; S100 Proteins

A metastatic melanoma is a ubiquitous tumor that spares no organ from metastases. Gastrointestinal involvement is a common occurrence in patients with a metastatic melanoma, and post mortem records have shown gallbladder involvement in about 15% of all gastrointestinal metastatic localizations. However, metastasis to the gallbladder as an isolated site is rare. Herein, an unusual case of a young man in whom a single metastatic gallbladder melanoma was the first and only metastatic site of the disease is reported. The clinical presentation, diagnosis, histopathology, prognosis and treatment of metastatic melanomas of the gallbladder are also reviewed.
Diagnosis ; Gallbladder* ; Humans ; Melanoma* ; Neoplasm Metastasis ; Prognosis

Primary malignant melanoma of the esophagus is extremely rare, but must be included in the differential diagnosis of polypoid esophageal mass, when such a lesion is observed on radiological examination. We report here a case of primary malignant melanoma in the esophagus that was noted to have strong enhancement on CT and high signal intensity on the T1 weighted MR image.
Diagnosis, Differential ; Esophagus* ; Melanoma* ; Tomography, Spiral Computed*