The diagnosis of nodular melanomas can be sometimes difficult, in case they lack the conventional clinical features of melanoma. Herein, we report a case of malignant melanoma mimicking seborrheic keratosis. The clinical diagnosis was seborrheic keratosis. The histopathologic examination revealed nodular melanoma with features of reticulated form of epidermal hyperplasia, pseudohorn cysts, and irregular hyperkeratosis and acanthosis. The tumor was excised with 2.5 cm margins and no remnant of tumor cells was found in the microscopic examination.
Diagnosis ; Hyperplasia ; Keratosis, Seborrheic* ; Melanoma*

Pigmented mammary Paget disease is a very rare clinicopathologic variant of mammary Paget disease. Diagnosis is often difficult because its clinical and histological features are very similar to those of malignant melanoma. Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma.
Diagnosis ; Melanoma* ; Paget's Disease, Mammary*

Omphalith is a compaction of keratinous and sebaceous material in the deeply set umbilicus. It may be clinically mistaken for a malignant melanoma because of its pigmented surface and sudden appearance. However, careful probing and removal of this umbilical mass, followed by histopathological examination readily identifies its true nature. We describe a patient who presented with a firm, black umbilical mass diagnosed as an omphalith and reviewed the differential diagnosis of a firm, black umbilical mass.
Diagnosis, Differential ; Humans ; Melanoma ; Umbilicus

We report a rare case of vaginal amelanotic melanoma. Malignant melanomas are cutaneous and extracutaneous tumors that arise from embryological remnants of neural crest cells/melanocytes. Amelanotic melanomas at such rare locations can be misdiagnosed both clinically and radiologically. Therefore, histopathological examination and immunohistochemistry are mandatory for the diagnosis of these tumors. We diagnosed this case using histopathology and confirmed the diagnosis based on the presence of immunohistochemical markers human melanoma black 45 (HMB45) and S-100.
Diagnosis ; Humans ; Immunohistochemistry* ; Melanoma ; Melanoma, Amelanotic* ; Neural Crest ; Vagina

Humans ; Melanoma ; diagnosis ; genetics ; Precision Medicine

The authors have experienced a case of extrascleral extension of choroidal malignant melanoma. The patient has suffered from the ocular pain and proptosis of right eye. We performed Kronlein operation under the clinical impression of the retrobulbar mass and obtained the histopathological diagnosis of malignant melanoma. Fifteen days after the operation, we performed exenteration and the rotation flap of temporalis muscle was inserted into the right eye ball socket through the lateral wall of the orbit.
Choroid* ; Diagnosis ; Exophthalmos ; Humans ; Melanoma* ; Orbit

BACKGROUND: MART-1(melanoma antigen recognized by T cell) is a well-known marker for malignant melanoma. Its immunoreactivity is also expressed in other melanocytic lineage. OBJECTIVE: Our purpose is to evaluate the usefulness of MART-1 in the diagnosis of malignant melanoma. METHODS: MART-1 immunostaining was performed in 26 cases of malignant melanoma and 12 cases of benign melanocytic nevi. HMB-45 immunostaining was performed in 26 cases of malignant melanoma. RESULTS: 1. Eighteen of 26 melanomas(69%) and 10 of 12 benign melanocytic nevi(83%) showed reactivity with MART-1. 2. HMB-45 showed a higher sensitivity(85%) than that of MART-1 in the staining of malignant melanoma. 3. Two of 5 HMB-45-negative melanomas were immunoreactive with MART-1, and 2 of 7 MART-1-negative melanomas were reactive with HMB-45. CONCLUSION:MART-1 immunostaining is not helpful to differentiate malignant melanoma from benign melanocytic nevi. MART-1 was immunoreactive to some cases of HMB-45 negative malignant melanoma. MART-1, together with S-100 protein and HMB-45, is another useful marker of malignant melanoma.
Diagnosis ; Melanoma* ; Nevus, Pigmented* ; S100 Proteins

Primary malignant melanoma of the esophagus is extremely rare, but must be included in the differential diagnosis of polypoid esophageal mass, when such a lesion is observed on radiological examination. We report here a case of primary malignant melanoma in the esophagus that was noted to have strong enhancement on CT and high signal intensity on the T1 weighted MR image.
Diagnosis, Differential ; Esophagus* ; Melanoma* ; Tomography, Spiral Computed*

Nail unit melanoma is a type of acral lentiginous melanoma and requires histopathologic examination for a confirmed diagnosis. However, inadequate biopsy techniques make definitive diagnosis difficult. A 61-year-old man presented with progressive nail pigmentation for 15 years, which was clinically highly suspicious for malignancy. Acral lentiginous melanoma was not detected in punch and longitudinal biopsy specimens, but en bloc excision tissue revealed melanoma. Acral lentiginous melanoma is known to have a heterogeneous pathologic manifestation depending on the pigmented region and the time it takes to progress. In this regard, en bloc excision can be considered as a first-line biopsy technique to diagnose acral lentiginous melanoma, indolent subtype.
Biopsy ; Diagnosis ; Humans ; Melanoma* ; Middle Aged ; Pigmentation

101-103 The authors have recently experienced a case of subretinal cysticercosis which simulated choroidal melanoma. Although it is benign variety, the eye was enucleated since the lesion was in the macular area and the patient was thought not to be able to gain an useful central vision after treatment. In the review of the literatures, the subretinal cysticercosis seems to occur much more frequently than the other ocular cysticercosis and it is very hard to get an exact diagnosis. The surgical removal may be difficult in procedure and the prognoses are poor in the cases of macular invorvement.
Choroid ; Cysticercosis ; Diagnosis ; Humans ; Melanoma ; Prognosis