Objective To investigate the correlation between the polymorphisms in GLIS3 and diabetic retinopathy in patients with type 2 diabetes in Northeast China.Methods Based on the case-control study,polymorphisms in GLIS3 were examined by PCR-RFLP in 120 cases of diabetic retinopathy in patients with type 2 diabetes (DR),120 cases of patients with type 2 diabetes without diabetic retinopathy (DNR),and 120 healthy individuals (NC).The odds ratio (OR) and 95％ confidence interval (C I) were calculated using unconditional logistic analysis.Results The resuhs demonstrated that GLIS3 rs7041847 AG,AG/GG genotype,or G allele was associated with an increased risk of DR and DNR (P ＜ 0.05).Moreover,GLIS3 rs7034200 CC,AC/CC genotype,or C allele was associated with an increased risk of DR and DNR (P ＜ 0.05).Conclusion In the patients in Northeast China,the polymorphisms in GLIS3 rs7041847 and rs7034200 were correlated with type 2 diabetes mellitus,while GLIS3 may not be associated with the susceptibility to diabetic retinopathy.

Hairy cell leukemia(HCL) is a rare malignant hematological tumor. This article presents the diagnosis and treatment of a patient with recurrent HCL. This patient, a 51-year-old female, was diagnosed with HCL in June 2013 and subsequently received monotherapy with cladribine. Post-treatment evaluation indicated a partial remission. In November 2023, she experienced chest tightness and shortness of breath with ultrasound revealing a right-sided pleural effusion. A follow-up examination in February 2024 confirmed the relapse of HCL. She was then treated with a combination of vemurafenib and rituximab, which resulted in a rapid complete remission without minimal residual disease. This case provides valuable insights into the management of recurrent HCL.