Objective To investigate the efficacy and safety of statins in primary and secondary stroke prevention.Methods We search in PubMed(1966—2006),Cochrane library(issue 1,2006),CNKI(1979—2006)and VIP(1989—2006)to get systematic reviews(SRs),meta-analyses and randomized controlled trials(RCTs)about statins for stroke prevention.Results We found 4 meta-analyses,8 RCTs about the primary stroke prevention and 1 Cochrane systematic review and an ongoing RCT about secondary stroke prevention.Conclusion Statins therapy can reduce the incidence of stroke,especially in high-risk patients with coronary heart disease,hypertension and diabetes.Statins have positive effect for primary stroke prevention and do not increase the incidence of hemorrhagic stroke and tumor.The clinical evidence about the effect of statins in secondary stroke prevention is insufficient.An ongoing stroke trial will provide important evidence for secondary stroke prevention.

Objective To investigate the influence of family support on the psychology and life quality of patients with diabetic retinopathy. Methods To survey the family support status, psychological status and quality of life by the questionnaire among 86 cases of diabetic retinopathy (DR) patients and to do the correlation analysis. Results Most of the dimension scores and total score of CLVQOL of the group of low score of family support (33 cases) were significantly lower than the group of high score of family support (53 cases). The score of somatization, compulsion, interpersonal sensitivity, depression, anxiety, paranoia, psychosis and the SCL-90 total score of family support group with low scores was significantly higher than the family support group with high scores. Conclusions The family support can help maintain and improve the quality of life and the status of mental health of patients. Health care workers should pay more attentions to the guidance and education of the DR family members of patients to enhance the awareness of timely improved family support, to ensure the provision of high quality family support and promote the quality of life of patients.

OBJECTIVE:To study the correlation between antibacterials amount and drug resistance of Echerichia coli,and to provide reference for clinical use of antibacterials. METHODS:Retrospective review was used to calculate DDDs of antibacterials and resistance rate of Escherichia coli to 11 kinds of antibacterials each quarter. The correlation analysis was carried out using the SPSS 13.0 statistical software. RESULTS:The resistance rates of E. coli to piperacillin/tazobactam,cefoperazone/sulbactam and le-vofloxacin were with upward trends,and the others showed downward trends. The resistance rates of E. coli to meropenem and imi-penem/cilastatin appeared in 2014,increasing from 0 to 8.8% and 9.4%,respectively. DDDs of them were significantly correlated to drug resistance of E. coli,showing positive correlation(r=0.915,0.793,P<0.01). DDDs of piperacillin/tazobactam was signif-icantly correlated to resistance rate of E. coli(r=0.807,P<0.01),while that of ceftazidime was negatively correlated to resistance rate of E. coli(r=-0.672,P<0.05). There was no statistical significance in resistance rate of E. coli to other 7 kinds of antibacte-rials. CONCLUSIONS:There are some correlations between the DDDs and resistance rates. We should strengthen the monitoring of bacterial resistance and the management of rational application of antibacterials.

Objective To analyze the application value of high risk human papillomavirus (HR HPV) DNA and thinprep cytolo-gy test(TCT ) detection in screening cervical cancer and to evaluate the clinical significance of their combined detection .Methods A total of 402 cases conducting cervical cancer screening in our hospital from March to May 2016 were selected and performed the HR HPV DNA and TCT detection .Those of suspected cervical lesions were performed the histopathological examination .Then the effects of HR HPV DNA and TCT combined detection were compared according to the pathological results .Results The detection positive rate of female HR HPV DNA was 27 .1% (109/402);abnormal and benign inflammation reaction were detected out in 46 cases of female TCT ,the positive rate was 11 .4% (46/402);in 123 cases of suspected cervical malignant lesion ,32 .5% females(40/123) appeared CIN Ⅰgrade or more lesions by histopathological examination ;the sensitivity of HR HPV DNA and TCT combined detection was higher than that of single detection ,the difference was statistically significant (P<0 .05);the specificity of HR HPV DNA and TCT combined detection was higher than that of HR HPV DNA single detection ,the difference was statistically signifi-cant(P<0 .05) ,but the difference was not statistically significant compared with TCT single detection (P>0 .05) .Conclusion The detection of HR HPV DNA and TCT is a good method for screening of cervical cancer ,the combined detection of HR HPV DNA and TCT can improve the detection rate of cervical precancerous lesion .

The anti-idiotypic antibodies Specific for anti-HBs were prepared by Immunizing New Zealand white rabbits with anti-HBs according to the method of Kennedy. The serum was first purified through IgG of normal human-Sepharose 4B affinity Column.The anti-idiotypic Specificity of the antibodies obtained was identified with ELISA or RIA inhibition test.The resultshowed that the anti-idiotypic antibodies were directed at the idiotypic determinants on anti-HBs,and no cross reaction between anti-idiotypic antibodies and normal human IgG.

OBJECTIVEThis study aimed at finding sensitive indicators in diagnosing facial growth pattern by studying the relationship between the indicators which can reflect facial growth pattern according to the previous studies and posterior-anterior ratio.

METHODSThe cephalometric radiographs of 61 teenage children were measured, the posterior-anterior ratio and the other 12 indicators including Y-axis angle, facial axis angle, cranial basal angle, and the four angles (The sagittal horizontal planes were analyzed using statistic methods.

RESULTSThe MP-SN angle was significantly coincided with the posterior-anterior ratio and Pearson coefficient is -0.922, and little correlation was found between the angles of four sagital horizontal planes and the posterior-anterior ratio. The positive correlation was found between the length of mandibular ramus and posterior-anterior ratio.

CONCLUSIONThe sensitive indicators for confirming facial growth pattern are the posterior-anterior ratio and the MP-SN angle.

Adolescent ; Cephalometry ; Child ; Dental Occlusion ; Face ; anatomy & histology ; Facial Bones ; anatomy & histology ; growth & development ; Female ; Humans ; Male ; Mandible ; anatomy & histology ; growth & development ; Maxillofacial Development ; Reference Values

10.3969/j.issn.2095-4344.2013.23.012

Objective:To evaluate the immunogenicity of an experimental SARS-CoV inactivated vaccine.Methods:The virus suspension of F69 strain was inactivated with 0.4% formaldehyde and purified,then used as the immune antigen combined with Freund′s adjuvant.Eight adult New Zealand rabbits were immunized 4 times with this vaccine.12 sets of rabbit serum were sampled from the third day to 74th day after first immunization.Titers of specific IgG antibody and neutralizing antibody were determined by indirect ELISA and micro-cytopathic effect neutralizing test.Results:Rapid and potent humoral immune responses were induced by F69 inactivated vaccine in all eight immunized rabbits.Both specific IgG antibody and neutralizing antibody all peaked just with 2 vaccinations,with the maximum titer of 1∶81 920 and 1∶20 480 respectively about 6 weeks after first immunization.Across neutralizing reaction existed between F69 and Z2-Y3 strains.Conclusion:F69 inactivated vaccine owns strong immunogenicity.Similar antigenic epitopes exist between the F69 strain and Z2-Y3 strain,which ensured the cross neutralizing reaction.

Objective To explore the relationship between personality and depression,especially to investigate mediating effect of positive mental characters.Methods A sample of 1 933 male recruits was assessed with eysenck personality questionnaire (EPQ),positive mental characters scale for recruits (PMCS-R) and self-rating depression scale (SDS).Results The scores of introversion-extroversion,psychoticism,neuroticism,positive mental characters and depression were 55.26±10.59,42.85±7.25,42.35± 11.67,3.80±0.64,0.45±0.11,respectively.There were correlations among personality,positive mental characters and depression in recruits (P＜0.05).Regression analysis indicated that introversion-extroversion,psychoticism and neuroticism predicted depression directly,and it could explain 42.6％ of the total variance (F=476.28,P＜0.05).Hierarchy regression analysis showed that positive mental characters mediate the relationship between personality (introversion-extroversion,psychoticism,neuroticism) and depression (the mediation effect was 0.22,0.19 and 0.11 respectively,P＜ 0.05).Conclusion Recruits' personality affects depression not only directly,but also indirectly through positive mental characters.

Objective To explore the mediating effect and moderating effect of positive mental characters in the relationship between childhood abuse and depression among recruits.Methods 1925 recruits aged from 16 ～24 were investigated using the Childhood Trauma Questionnaire-28 item Short Form (CTQ-SF),Self-Rating Depression Scale (SDS) and Positive Mental Characters Scale for Recruits (PMCS-R) through random cluster sampling.Results The scores of emotional abuse,physical abuse,sex abuse,emotional neglect,physical neglect,depression,positive mental characters were 6.11±1.69,5.49±1.32,5.61±1.45,9.15±3.66,9.57±2.93,0.45±0.11,3.80±0.64,respectively.There were correlations among childhood abuse,depression and positive mental characters (P＜0.05).Emotional neglect,physical neglect and emotional abuse could explain 28.6％ of the total variance of depression (F=256.72,P＜0.05).The positive mental characters partially mediated the relationship between emotional neglect,physical neglect,emotional abuse and depression (mediating effect were 0.19,0.15 and 0.09,respectively),and it could only moderate the relationship between emotional neglect and depression (F=24.73,P＜0.05).Conclusion Childhood abuse not only directly but also indirectly affects depression through the positive mental characters;meanwhile the positive mental characters can change the relationship between childhood abuse and depression.