Objective To observe the changes of abdominal oxygen saturation in very low birth weight infants (VLBWI)with feeding intolerance (FI)within 1 4 days after birth monitored by near infrared spectroscopy (NIRS).Methods VLBWI fitting entry criteria were enrolled into this study.NIRS monitoring was carried out to detect cerebral oxygen saturation (ScO2 )and abdominal oxygen saturation (SsO2 ).Data were analyzed between FI infants and feeding tolerance (FT)infants.FI was defined as follows:gastric residual of more than 50% of the previous feeding volume;emesis or abdominal distention or both;decrease,delay or discontinuation of enteral feedings. Results 93 VLBWI were enrolled.52 cases(55.91 %)presented with FI,including 29 cases(31 .1 9%)of gastric residual increasing and 23 cases(24.73%)of emesis with or without abdominal distention within 1 4 days after birth. The levels of SsO2 and SsO2 /ScO2 showed no differences in infants with FT and with FI within 24h after birth (P >0.05).The change rates of the median of SsO2 and SsO2 /ScO2 in FT infants were similar during 1 4 days (P >0.05).While both the change rates of SsO2 and SsO2 /ScO2 were markedly decreased 1 day before and the day of FI (P <0.01 ).The decreasing degree of SsO2 was similar between infants with gastric residual increasing and infants with emesis with or without abdominal distention[(1 6.2 ±5.1 )vs (1 7.4 ±3.6)%,t =0.733,P =0.476]. Conclusion Abdominal oxygen saturation measured by NIRS may be a useful method for infants adjusting the feeding plan.

Objective:To explore the effects of transcutaneous electric nerve stimulation (TENS) combined with cognitive behavior intervention in the elderly coronary disease patients with hypertension.Methods:From May 2017 to May 2019, we selected 90 elderly coronary disease patients with hypertension in the Second Affiliated Hospital of Harbin Medical University as subjects by convenience sampling. All of patients were divided into control group and observation group with the method of random number table, 45 cases in each group. Control group carried out cognitive behavior intervention, while observation group implemented the TENS combined with cognitive behavior intervention. We compared the angina pectoris symptom control, blood pressure control and the self-perceived burden with the Self-perceived Burden Scale (SPBS) of patients between two groups.Results:After intervention, the effective rate of angina pectoris control of observation group was higher than that of control group with a statistical difference ( P<0.05) ; the diastolic pressure and systolic pressure of observation group were lower than those of control group with statistical differences ( P<0.05) ; the score of SPBS of patients in control group was higher than that in control group also with a statistical difference ( P<0.001) . Conclusions:TENS combined with cognitive behavior intervention for elderly coronary disease patients with hypertension contributes to angina pectoris symptom control and reducing the blood pressure as well as self-perceived burden.

The high morbidity and mortality of non-small cell lung cancer (NSCLC) did influence the quality of life of tumor patients world-wide. There is an urgent need to develop new therapies that have high anti-tumor activity and low toxicity side effects. It is widely accepted that autophagy can play diverse roles in carcinogenesis, such as induces pro-death of lung cancer cells or helps the escape from cell death, making it become a proper anticancer target. It's believed that various monomers of Chinese traditional medicine closely correlates to anti-NSCLC activities, and that even could affect the acquired multiple drug resistance (MDR). Furthermore, autophagy might be the underling mechanisms which could play a role as the candidate targets of natural active compounds. Recent studies of terpenoids, alkaloid, dietary polyphenols, saponins and other active ingredients that extracted from a large variety of herbs suggest that different monomer compounds could either regulate the activity of pro-death autophagy or influence the level of protective autophagy of NSCLC cells, thus changing their drug sensitivity and cell viability. This paper aims to give a systemic description of the latest advances about natural compounds and their derivatives that involved in tumorigenesis of NSCLC via inducing the autophagy.

Due to the drawbacks of low specificity and high risk of side effects of traditional anti-tumor treatments in clinical practice,novel anti-tumor immunotherapy has received attention and has been gradually applied.Tumor immunotherapy is to enhance the anti-tumor immune response by regulating the body's immune system in order to achieve control and killing of tumors.Tumor immunotherapies include immune checkpoint blockade therapy,over-the-counter cellular immunotherapy and tumor vaccines.Among them,the tumor vaccine stimulates the immune system to produce specific immune cells or antibodies by delivering tumor cell-specific antigens thereby eliminating the tumor cells for the purpose of treating the tumor.In recent years,The field of mRNA vaccines is developing rapidly,and the required mRNA in the synthesis and preparation of the process has been developed and matured,laying a good foundation for the research of tumor mRNA vaccine.Because of the fact that mRNA is easily degraded and cannot enter the cell autonomously,this vaccine requires a suitable delivery vehicle to be successfully taken up by the cell to be effective.Therefore,the development of mRNA vaccine delivery systems has become critical for their better utilization,which is also an important part of whether mRNA vaccines can be developed and utilized for the clinical stage in the field of tumor therapy.This paper briefly introduced the immunotherapeutic methods for tumors,types of tumor vaccines and the mechanism of action and preparation methods of tumor mRNA vaccines,reviewed the research progress and related applications of mRNA vaccines and their common delivery systems in immunotherapy for tumor treatment,and summarized the tumor mRNA vaccines that entered into the phase of clinical trials with the aim of providing assistance for the research of mRNA vaccines for tumors in the future.