OBJECTIVETo investigate the anti-apoptosis effects of Rubus alceaefolius total alkaloids in rats with hepatic injury.

METHODThe hepatic injury model of rat was induced by intraperitoneal injection with CCl4. Sixty SD rats were randomly divided into the normal group, the model group, the R. alceaefolius total alkaloids intervened group, and the bifendate intervened group. The expressions of the levels of liver cell apoptosis were determined by TUNEL. Ultrastructures of the liver cells were observed with transmission electron microscope.

RESULTCompared with the model group, the degree of hepatic injury and the positive expressions of apoptosis in liver tissues in the R. alceaefolius total alkaloids intervened groups and the bifendate intervened group were significantly lower.

CONCLUSIONR. alceaefolius total alkaloids could reduce the pathological changes and degree of hepatic injury in rats, which may be partially through inhibiting the expressions of apoptosis in liver tissue.

Alkaloids ; pharmacology ; therapeutic use ; Animals ; Apoptosis ; drug effects ; Disease Models, Animal ; Female ; Hepatitis, Animal ; drug therapy ; metabolism ; pathology ; In Situ Nick-End Labeling ; Liver ; drug effects ; metabolism ; pathology ; ultrastructure ; Male ; Rats ; Rats, Sprague-Dawley ; Rosales ; chemistry