Objective To study the feasibility of non-invasive spatially-resolved near-infrared spectroscopy (SR-NIRS) in clinical bedside monitoring of shock.Methods The central venous blood samples of 25 patients with shock were collected and the central internal jugular central vein oxygenation (ScvO2) level was measured.The self-developed non-invasive SR-NIRS device was used to measure tissue blood oxygen saturation (StO2) surrounding the region of jugular central vein.In addition,the artery oxygen saturation (SaO2) and partial pressure of oxygen (PO2) were also measured using conventional methods.The correlation between StO2 between ScvO2,SaO2 and PO2 was analyzed.Results StO2 levels in shock patients were highly correlated with ScvO2 levels (r=0.84,P＜0.001) and the concordance coefficient of 0.80 was high.Conclusion StO2 value collected from the surrounding region of jugular central vein by SR-NIRS device can be used as an indicator of shock suggesting the potential of noninvasive SR-NIRS for bedside shock monitoring.