AIM: To determine the relevance of NADPH oxidase subunit p22hox and the expression of superoxide anion on ventricular remodeling in myocardial infarction (MI) rats. METHODS: MI of Sprague-Dawley rats were established by left anterior descenting coronary artery ligation. 8 weeks after MI, Doppler echocardiography, hemodynamic study and histomorphometry were performed to analyze the ventricular remodeling. The level of thiobarbituric acid reactive substance in plasma and myocardium were measured, and the distribution of superoxide anion was observed with laser scanning confocal microscope. The expression of p22phox mRNA and protein level was detected by RT-PCR and immunohistochemistry. RESULTS: The left ventricular remodeling was significant in MI rats, also the level of thiobarbituric acid reactive substance increased in the plasma and non-infarcted myocardium. The expressions of p22-phox mRNA and protein levels, and superoxide anion increased in infarcted and non-infarcted myocardium in MI rats. CONCLUSION: Our results suggest that the expression of NADPH oxidase and its derived superoxide anion may take part in left ventricular remodeling through oxidative stresss after MI.

AIM: To clarify the protective effect of long-term administration of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor fluvastatin on ventricular remodeling after myocardial infarction (MI) in rats and its mechanisms. METHODS: Myocardial infarction were established by ligated left coronary anterior artery in SD rats, 24 hours after the operation, the survival rats were treated by gavage fluvastatin (20 mg?kg~(-1)?d~(-1)) or distilled water for 8 weeks. Doppler echocardiography, homodynamic and cardiac histomorphometry were used to assess the ventricular remodeling and cardiac function. The plasma levels of total cholesterol (Tch), creatinine (Cr), glutamic-oxal (o) acetic transaminase (AST), lipid peroxidation (LPO), glutathione perioxidase (GSH-PX), nitrogen monoxide (NO_2~-/NO_3~-) were detected. RESULTS: The Tch, Cr and AST were not significant difference in groups. Left ventricular end-diastole pressure, right relative weight, left ventricular posterior wall thickness, collagen volume fraction and the lung weight were decreased in AMI+fluvastatin group compared to AMI group (P

Objective To study the features of eye wounds in subtropical mountain and bush zone so as to improve success rate of medical therapy and decrease disability rate for eye wounds. Methods The clinical data of eye wounds caused by Selfdefense War against Vietnam from No. 59 Hos-pital of PLA were analyzed. Results Monocular injuries accounted for 81.7% of eye wounds, with no statistical difference in the injuries between left eye and right eye. Eye wounds caused by shrapnel ac-counted for 82.2%, and it was the main injury factor. The rate of eye injuries complicated with other in-juries of the body was up to 75.6%. Globe wounds were the most commonly seen, with open globe wound accounting for 45.1%. Conclusion Timely and correct ophthalmological treatment can effectively re-duce the blinding rate.

Objective:To study the correlation of C(-938)A single nucleotide polymorphism (SNP) in the promoter of anti-apoptosis gene Bcl-2 with the clinical biological parameters of breast cancer patients in Hebei Province. Methods:Three genotypes(AA, AC, CC) of Bcl-2 C(-938)A from 113 samples of breast cancer patients were analyzed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, and the results were associated with clinical biological parameters. The distribution of genotype frequency was compared between different groups. Results:When stratified for axillary lymph node metastases, the frequency of AA genotype were 26.8%, 47.8% and 52.6% and the distribution of AC+CC genotypes were 73.2%, 52.2% and 47.4% in negative group, 1-3 metastasis group, and ≥4 metastasis group. The difference between the two groups was significant (χ~2=6.337, P=0.042). Compared with the AC+CC genotypes, the OR value of AA genotype in ≥4 metastasis group was 3.041 (95%CI=1.072-8.626). The frequency of AA genotype were 30.9% and 69.1% in gradeⅠ-Ⅱ group and grade Ⅲ group, and the frequency of AC+CC genotypes were 57.9% and 42.1%. The difference between the two groups was significant (χ~2=5.055; P=0.025). Compared with the AC+CC genotypes, the OR value of AA genotype in differentiated tumors(grade Ⅲ)was 3.082 (95%CI=1.122-8.465). Stratified for estrogen receptor (ER), progesterone receptor (PR) and C-erbB2, there was no difference between the distribution of AA genotype and AC+CC genotypes (χ~2=3.005, χ~2=1.504, χ~2=1.163, P>0.05). Conclusion:The AA genotype of Bcl-2 gene C(-938)A maybe correlated with high lymph node metastasis rate and poor differentiation.

OBJECTIVE To investigate the efficacy of coblation in upper airway obstruction patients. METHODS Coblation Channeling was used in 814 obstructed nasal airway patients.Soft palate coblation with or without tonsil treatment was applied in 67 adult OSAHS patients.Coblation tonsillectomy or tonsillotomy with adenoidectomy was performed in 68 pediatric OSAHS patients.RESULTS For obstructed nasal airway patients,VAS scores of 720 (88.45 %) patients were 0 to 1 after one time treatment.Thirty-five (4.3 %) patients had second treatment,and then VAS scores dropped to 0 to 1.VAS scores of 59 (7.25 %) patients kept more than 5.For adult OSAHS patients,3 (4.5 %) patients were cured,38 (56.7 %) patients were improved, 19 (28 %) patients were effective and 7 patients were not improved.For pediatric OSAHS patient s,58 (85.29 %) patients' symptoms,such as snoring,breath difficulty, mouth breathing,or pharyngeal obstruction,were relieved and 10 (14.71%) patients' symptoms were improved. CONCLUSION Coblation is widely used in ENT patients with good results.Its advantages include easy to use, minimal invasive,safe,and much less pain.It is specially suitable for pediatric OSAHS patients.