1.The Mediating Effect of College Student’s Loneliness Between Social Support and Internet Addiction Tendency
Guangwen SONG ; Fang KONG ; Meiting LIU ; Xiaofan YUAN
Chinese Journal of Clinical Psychology 2001;0(03):-
Objective: To explore the structural relationship of social support,loneliness and internet addiction tendency.Methods: Questionnaires were used to investigate 355 college students.Results: The internet addiction tendency of college students had significant negative correlation with social support total scores and subjective social support,and positive correlation with the total scores and every dimensions of loneliness;college students’ social support had significant negative predictive effect on internet addiction tendency;loneliness of college student played a completely mediating role between social support and internet addiction tendency.Conclusion: Loneliness of college students plays a completely mediating role between social support and internet addiction tendency.
2.Growth and repair potential of three species of bacteria in reclaimed wastewater after UV disinfection.
MeiTing GUO ; JingJing HUANG ; HongYing HU ; WenJun LIU
Biomedical and Environmental Sciences 2011;24(4):400-407
OBJECTIVEThe growth and repair potential of three typical microorganisms in reclaimed water after UV disinfection was investigated to assess the effects of photo-reactivation and dark repair of microorganisms, and the microbial safety of reclaimed water following this procedure.
METHODSThe growth and repair potential of Escherichia coli, a fecal coliform strain and Bacillus subtilis in the effluent of a biological wastewater treatment plant disinfected by a low-pressure UV lamp were investigated.
RESULTSAny increase in bacterial numbers in the effluent after UV disinfection was due to damage repair. Exposure to photo-reactivating light for 8-10 h after UV irradiation with a dose of 5 mJ/cm(2), the highest percentage of photo-reactivation observed for E. coli and the fecal coliform strain was 29% and 15% respectively. B. subtilis showed little photo-reactivation under these conditions. The percentage of photo-reactivation was related to the UV dose and the photo-reactivating time, and a function was developed to forecast the final concentrations of E. coli and the fecal coliform strain after UV disinfection with possible photo-reactivation.
CONCLUSIONDifferent species of bacteria displayed different responses to UV light and different repair potentials. The repair of indigenous bacteria in wastewater needs to be investigated in future work.
Bacillus subtilis ; radiation effects ; Dose-Response Relationship, Radiation ; Escherichia coli ; radiation effects ; Time Factors ; Ultraviolet Rays ; Waste Disposal, Fluid ; Water Microbiology ; Water Purification
3.Studies on the mechanism of Syk and JNK in the heart tissue of type 1 diabetic rats
Yufeng CHEN ; Guangfeng LONG ; Xixi TIAN ; Yingchun QIAO ; Shengyu LI ; Meiting XUE ; Yunde LIU ; Yujie CUI ; Yanna SHEN
Tianjin Medical Journal 2017;45(5):463-467
Objective To investigate the expressions of spleen tyrosine kinase (Syk), c-Jun amino terminal kinase (JNK) and nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in the heart tissue in SD rat model of diabetic cardiomyopathy, and to explore the relationship between Syk, JNK and NLRP3. Methods Clean male SD rats were randomly divided into the control (Ctrl) group and diabetic cardiomyopathy model (DCM) group. Rats of DCM group were treated with a single intraperitoneal injection of streptozotocin (STZ), while rats of Ctrl group were injected with the same dose of citrate buffer. The random blood glucose level and body weight were monitored every week until 20 weeks after STZ or citrate buffer injection, then all the rats were killed and their hearts were obtained. Rat H 9c2 cardiomyocytes were randomly divided into normal glucose treatment (NG) group, high glucose treatment (HG) group, Syk inhibitor control (BAY) group and Syk inhibitor high glucose (HG+BAY) group. The Syk and JNK phosphorylations and NLRP3 protein expression were detected by Western blot assay in the heart tissue of SD rats and H9c2 cardiomyocytes. The NLRP3, cysteine-containing aspartate specific protease 1(caspase-1) and interleukin (IL)-1β expressions at mRNA level were detected by reverse transcription-polymerase chain reaction (RT-PCR). Results The random blood glucose level was significantly increased (P<0.05) and the body weight was significantly decreased (P<0.05) in DCM group compared with those of Ctrl group. The expressions of cardiac p-Syk, p-JNK and NLRP3 at protein level were significantly increased in DCM group compared with those of Ctrl group (P<0.05). Furthermore, the mRNA levels of NLRP3, caspase-1 and IL-1β were significantly up-regulated (P < 0.05). BAY treatment significantly inhibited the high glucose-induced NLRP3, caspase-1 and IL-1β mRNA expressions and p-JNK, NLRP3 protein expressions in H9c2 cardiomyocytes (P < 0.05). Conclusion JNK phosphorylation and NLRP3 inflammasome activation induced by Syk play an important role in the pathogenesis of diabetic cardiomyopathy.
4.Cariporide pretreatment attenuated warm ischemia/reperfusion injury in an isolated rat lung: a study on antioxidative mechanism.
Xinzhu LIN ; Meiting LI ; Ronghua ZHOU ; Hai YU ; Leng ZHOU ; Qian LI ; Bin LIU
Journal of Biomedical Engineering 2010;27(1):132-137
This experimental study was designed to explore the possible mechanisms of Cariporide, a kind of Na+/H+ exchanger inhibitor, for protecting the lung from warm ischemia/reperfusion injury (WI/RI) of isolated rat lung model. Thirty isolated rat lungs were established on the Langendorff apparatus and randomly divided to three groups (n = 10, each): control group (C group), ischemia/reperfusion group (IR group) and Cariporide group (CP group). Mean pulmonary artery pressure (MPAP) and peak airway pressure (pAwP) were monitored continuously. At the end of reperfusion, right bronchoalveolar lavage was performed, bronchoalveolar lavage fluid (BALF) recovery rate (BALFRR) was recorded, and protein content in BALF was measured. Lung water content (LWC), malondialdehyde (MDA) and superoxide dismutase (SOD)of left lung tissue were measured; histomorphology evaluation was performed under light microscope and transmission electron microscope. In comparison with the data from IR group, BALF protein concentration, LWC, MDA content and MPAP content of reperfusion were significantly decreased, but SOD activity was increased in CP group. Histomorphologic feature also showed that pathological change significantly reduced in CP group. In this rat WI/RI model, the mechanism by which the selective Na+/H+ exchanger inhibitor (Cariporide) attenuates lipid peroxidation induced by WI/IR may be: preventing Ca2+ overload via inhibiting the transport of Na+/H2 exchanger-1 (NHE1) in the context of the coupled exchanger, thereby reducing the activation of xanthine oxidase pathway and oxygen free radical liberation which is dependent on certain intracellular Ca2+ concentration, and lastly promoting the endogenous antioxidative mechanism.
Animals
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Antioxidants
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pharmacology
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Guanidines
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pharmacology
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In Vitro Techniques
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Ischemic Preconditioning
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Lung
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blood supply
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Male
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Rats
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Rats, Sprague-Dawley
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Reperfusion Injury
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etiology
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prevention & control
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Sodium-Hydrogen Exchangers
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antagonists & inhibitors
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Sulfones
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pharmacology
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Superoxide Dismutase
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metabolism
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Warm Ischemia
5. 3D electronic anatomy mapping guided radiofrequency catheter ablation in 95 children with atrioventricular nodal reentrant tachycardia
He JIANG ; Xiaomei LI ; Meiting LI ; Xiaochun ZHENG ; Haiju LIU ; Yi ZHANG ; Haiyan GE
Chinese Journal of Pediatrics 2018;56(9):674-679
Objective:
To investigate the clinical features and evaluate the efficacy of radiofrequency catheter ablation (RFCA) guided by 3D electronic-anatomy mapping system (CARTO3 System) in children with atrioventricular nodal reentrant tachycardia (AVNRT).
Methods:
This was a retrospective case-controlled study. Data were collected from 95 children with AVNRT who underwent RFCA using CARTO3 System in the first hospital of Tsinghua University from January 2014 to December 2017. The onset age, characteristic of electrophysiology and anatomy feature of Koch triangle were analyzed. The efficacy and safety of ablation and X-ray fluoroscopy were compared with control 135 children with AVNRT who underwent RFCA without using CARTO3 System. The
6. Clinical features and outcomes of radiofrequency catheter ablation of atrial flutter in children
He JIANG ; Xiaomei LI ; Yi ZHANG ; Haiju LIU ; Meiting LI ; Haiyan GE
Chinese Journal of Pediatrics 2017;55(4):267-271
Objective:
To explore the clinical features of atrial flutter (AFL) and evaluate the efficacy of radiofrequency catheter ablation (RFCA) for AFL in children.
Method:
Data were collected and analyzed on 50 consecutive pediatric AFL patients (male 37/female 13) who underwent electrophysiology study and RFCA from February 2009 to November 2016 in a case observational study. The average age was (6.2±3.5) years and body weight was (23.7±13.5) kg. Heart structure was normal in 26 patients. Twenty-four patients had congenital heart disease (CHD) and among them 22 patients underwent repaired surgery before. Patients were followed-up for 1 month to 7 years after RFCA. Clinical features and the outcomes of RFCA in AFL patients were analyzed.
Result:
The average onset age was (4.2±3.3) years. Of these patients, 84% had persistent AFL and 16% paroxysmal AFL. AFL with sick sinus syndrome (SSS) occurred in 36% patients without statistically significant difference between the groups with and without CHD (38.9%(7/18)
8. Clinical challenges in the management of catecholaminergic polymorphic ventricular tachycardia in children
Haiyan GE ; Xiaomei LI ; He JIANG ; Yi ZHANG ; Haiju LIU ; Xiaochun ZHENG ; Meiting LI
Chinese Journal of Pediatrics 2017;55(12):926-931
Objective:
Catecholaminergic polymorphic ventricular tachycardia (CPVT) accounts for up to 10%-15% sudden cardiac death (SCD) in the children and young population. This study aimed to assess the current situation and challenges in CPVT clinical diagnosis.
Method:
A retrospective review included 11 children (7 male patients) at the First Hospital of Tsinghua University clinically diagnosed with CPVT from June 2014 to July 2017. Each patient was evaluated with detailed history, physical examination, resting 12-lead electrocardiogram(ECG), 24-h Holter, exercise stress test, Doppler echocardiography and genetic test.
Result:
During physical activity and/or emotional stress, ten children presented with recurrent syncope and one child presented with palpitation and chest distress. The mean age of symptom onset was 8.4 (4.0-13.7) years with a delayed diagnosis of 2.4 (0.04-5.00) years. Two children had a familial history of syncope or sudden death. Nine children were initially misdiagnosed as complex arrhythmic conditions (
9. Multicenter investigation of the correlation between supraventricular tachycardia and tachycardia-induced cardiomyopathy in children
Xiaomei LI ; Haiyan GE ; Lin SHI ; Xueqin LIU ; Baojing GUO ; Meiting LI ; He JIANG ; Yi ZHANG ; Haiju LIU ; Xiaochun ZHENG ; Aijie LI ; Yuanyuan ZHANG
Chinese Journal of Pediatrics 2017;55(9):668-671
Objective:
This study aimed to investigate the correlation between supraventricular tachycardia (SVT) and tachycardia-induced cardiomyopathy(TIC) in children and assess the risk factors for the development of TIC.
Method:
One hundred and eighty-three patients were recruited in four hospitals of Beijing diagnosed as SVT were divided into two groups depending on whether or not complicated with TIC. The age, gender, tachycardia type, ventricular rate during tachycardia, frequency of tachycardia episodes and duration of tachycardia were compared between the two groups and risk factors associated with TIC were analyzed. Statistical analyses were performed using
10. An analysis of clinical characteristics and acute treatment of supraventricular tachycardia in children from a multicenter study
Xiaomei LI ; Haiyan GE ; Xueqin LIU ; Lin SHI ; Baojing GUO ; Meiting LI ; He JIANG ; Yi ZHANG ; Haiju LIU ; Xiaochun ZHENG ; Aijie LI ; Yuanyuan ZHANG
Chinese Journal of Pediatrics 2018;56(1):13-18
Objective:
The study assessed the clinical characteristics and response to acute intravenous antiarrhythmic drug therapy of supraventricular tachycardia (SVT) in children.
Methods:
This was a multicenter prospective descriptive study including 257 children from First Hospital of Tsinghua University, Peking University First Hospital, Children's Hospital Affiliated to Capital Institute of Pediatrics and Beijing Anzhen Hospital who received intravenous antiarrhythmic drug therapy for SVT from July 2014 to February 2017. The clinical and tachycardia features, response to intravenous antiarrhythmic drug therapy of these children were characterized. Statistical analyses were performed using