Objective To explore the clinical value of monitoring intra-abdominal pressure ( IAP) in the monitoring and treatment of patients with severe acute pancreatitis .Methods The changes of IAP in 82 patients with severe acute pancreatitis in the intensive care unit were dynamically monitored , and the effects of the increased IAP on respiratory , hemodynamic , kidney function and so on were analyzed , and the early intervention was carried out .Results No differences were found in the changes of heart rate , blood pressure , peripheral blood oxygen saturation , respiratory before and after the first measurements of IAP in 82 patients(P>0.05).The CVR, HR, oxygenation index, MAP and IAP in 54 patients with increased IAP were respectively (17 ±5) cmH2O, (132 ±18) beats/min, (240 ±60), (45 ±12) mmHg and (22 ±8) mmHg before the intervention, and were (13 ±4) cmH2O, (118 ±12) beats/min, (320 ±80), (65 ±8) mmHg and (12 ± 6) mmHg after the intervention, and the differences were statistically significant ( t =4.59, 5.58, 5.88, 10.19, 7.35, respectively;P<0.01).Conclusions The increased IAP correlates closely with the condition and prognosis of patients with severe acute pancreatitis .The routine IAP monitoring for patients with severe acute pancreatitis is helpful to the evaluation of condition and prognosis , and is also helpful to take timely and effective treatment and nursing , and can prevent the occurrence and development of abdominal compartment syndrome and assist the judgment of operation time for severe acute pancreatitis .