Objective To establish a method for determination of 22 pesticide residues in vegetables by QuEChERS - gas chromatography-mass spectromerty. Methods The vegetables were extracted by acetonitrile, and purified by QuEChERS after being centrifuged. The sample solution was dried by nitrogen gas. The residues were then dissolved in cyclohexane /acetone (7:3) and analyzed by gas chromatography-mass spectrometry with HP-5MS and scanned by select ion scanning mode（SIM）for quantification. Results The separation of the 22 pesticide residues was good, and the linear correlation coefficients were all greater than 0.996. The detection limits were 0.001 mg/kg-0.003 mg/kg. The average recovery rate was in the range of 86.00% to 102.00% with relative standard derivations of 2.10% to 4.30%. Conclusion QuEChERS - gas chromatography-mass spectromerty is a simple, fast, sensitive, and accurate method, which is suitable for the detection of various pesticide residues in vegetables.