Objective To investigate effect of wenxin granule combined with metoprolol on blood rheology and clinlical efficacy of patients with premature hypertension heart disease.Methods 71 cases of hypertensive patients with hypertension and ventricular premature beat were selected, and randomly divided into a control group of 34 cases and observation group of 37 cases.The control group received metoprolol, the observation group on the base of the control group with wenxin granule.Blood rheology level, clinical efficacy and adverse reaction rate were compared before and after the treatment.Results Before treatment, high blood viscosity, whole blood low shear viscosity, plasma viscosity and fibrinogen levels had no significant difference in two groups of patients.After treatment, these indexs reduced compared with the same group pre-treatment(P<0.05);compared with the control group, the observation group had lower blood rheology(P<0.05), the total effective rate was higher(χ2 =8.60,P<0.05), and the incidence rate of adverse reactions was no difference.Conclusion Wenxin Granule combined with metoprolol in treatment of hypertension and ventricular premature beat patients, can improve effectively blood rheology of patients, and has low adverse reactions.