Objective To investigate the status of care burden and quality of life in primary caregivers of glioma patients,and to explore the correlation between the two.Methods A total of 170 primary caregivers of glioma patients were recruited from a level three class A hospital in Shanghai.Self-designed questionnaire about general condition,Zarit caregiver burden interview (ZBI) and caregiver quality of life (C-QOL) were used in them.The statistics data were dealt with descriptive analysis and Pearson correlation analysis.Results The total ZBI scores of 170 primary caregivers were (33.76 ± 10.12) points,and personal burden and responsibility burden scores were (16.65 ± 6.19) points and (9.27 ±3.15) points as medium burden.The total QOL score of 170 primary caregivers were (114.91 ± 14.43) points,in which physical status (PS) was (3.99 ± 5.37),metal status (MS) (23.17 ± 6.37),social concerns (SC) (25.97 ± 7.42),and spiritual status (SS) (41.77 ± 7.54).The correlation between ZBI and QOL were positively correlated (r =0.373-O.621,P ＜ 0.01).Conclusions The burden of primary caregivers caring for patients with glioma was moderate to severe.Their quality of life was generally poor.It is recommended for clinical staff should take effective care measures to reduce primary caregivers care burden and improve their quality of life.