Objective To investigate ATM deletion [del (ATM)] in chronic lymphocytic leukemia (CLL) and study its correlation with the clinical stage. Methods Spectrum Orange~(TM) labeled sequence specific DNA probe for ATM locus on 11q22.3 and fluorescence in Situ hybridization (FISH) was used to examine del (ATM) in 28 newly diagnose patients with CLL. FISH analysis were performed on bone marrow smears. Clinical staging was done according to Binet Method.Fisher exact propability was used to study the relations between del (ATM) and clinical feature. Results 4 out of the 28 cases were found with deletion of ATM. The incidence of del (ATM) in BinetA, BinetB and BinetC was 1/9 (11.1 %), 1/8 (12.5 %), 2/11 (18.2 %), respectively. Fisher exact propability showed that deletion of ATM was not associated with its clinical feature. Conclusion Application of FISH on archival bone marrow smears is a simple, liable method, and can be readly used to retrospective study of clonal blood system diseases. Deletion of ATM was common cytogenetic changes in CLL patients.And the significance of del (ATM) in the prognosis of CLL in China needs to be further investigated.

Objective To study the over-expression and clinical implications of the oncogene MDM2 in acute leukemia (AL). Methods The expression of MDM2 gene in 100 patients with newly diagnosed and relapse or refractory AL and 20 healthy as control was measured by relative quantitative reverse transcriptase polymerase chain reaction (RT-PCR),then the results was measured by χ2-test,t-test and one-way ANOVA to compare expession positive rate and intensity of MDM2. Results Among 100 patients,fifty-eight had the high expression of MDM2 gene (58 %). The expression level of MDM2 gene in patients was higher than that of health controls(P ＜0.05). The expression positive rate of MDM2 is higher in poor outcome group (67.9 %,19/28)than that in general outcome group (33.9%,19/56) (P＜0.05). Conclusion Our results suggest that the expression of MDM2 gene plays an important role in the pathogenesis and poor outcome of AL.

Objective:Scope review of exercise-related research in patients with inflammatory bowel disease (IBD), while pointing out the limitations of existing research, and providing references for future studies in this area.Methods:We searched PubMed, EMBASE, Web of science, Cochrane databases, China Biology Medicine, Chinese National Knowledge Infrastructure, Wan Fang Data, and Chinese Science Journal Database for studies related to exercise intervention in patients with IBD from January 1974 to July 2020. We extracted data from the included studies. Then we summarized and presented the results.Results:16 articles were finally included, of which 14 were randomized controlled trials and 2 were quasi-experimental studies. Results show that exercise methods can be divided into four categories: aerobic exercise, resistance exercise, flexibility exercise and mixed exercise. The intensity of exercise was mostly low to moderate. The frequency of exercise was mostly 3 times/week, lasting for 30-60 minutes per session. The results showed that exercise had positive effects on physical fitness, bone density, anxiety and depression, quality of life among patients with IBD. However, the effect of exercise on disease activity are diverse.Conclusion:exercise is beneficial to the mental and physical health among this group, but the existing studies have small sample sizes, short exercise intervention period, neglect of individualization in exercise prescription design, low exercise compliance, non-uniformity of exercise effect evaluation indicators.

Self-disclosure is a simple and effective intervention to improve the health outcomes of patients. Foreign scholars have paid attention to it and applied it in the self-management of patients with chronic diseases widely. However, there are few domestic related studies in China. This article reviewed the definition, significance, assessment tools, and summarized the influencing factors and intervention studies of self-disclosure in patients with chronic diseases. It would provide references for research of self-disclosure, further improving the self-management and mental health of patients with chronic diseases.

Objective: To compare the effectiveness of Internet plus mode with tradition education mode on tuberculosis prevention in schools,so as to provide the reference for reducing the risk of catching tuberculosis in schools. Methods: Two junior and two senior high schools as well as two universities were selected from Baoding. The two same level schools were randomly divided into the traditional education group and the Internet plus group. All the students received 2-month TB health education intervention. Questionnaire survey was conducted before and after intervention. A total of 2 804 and 2 821 students were investigated before and after intervention respectively. Results: The awareness rate of TB prevention and treatment core knowledge among the traditional education group and the Internet plus group before intervention was 47.5% and 47.8%, respectively (χ2=0.19, P>0.05). After intervention, the percentage of students with positive attitude and behavior regarding TB was 93.0% and 85.1% in the Internet plus group and the traditional model education group, respectively, including willingness to accept TB test (88.6% vs 81.5%), active reporting to school on TB diagnosis (96.4% vs 90.5%), no spitting in public, cover up when sneeze or cough (94.3% vs 90.6%), opening windows for ventilation (98.1% vs 95.7%), and willingness to share knowledge (98.7% vs 96.4%), active prevention of TB (86.3% vs 78.2%)(P<0.05). Conclusion Internet plus mode health education intervention shows more effectiveness on tuberculosis health education, compared with traditional health education.

The eating habits of children developed during infancy and toddlerhood is the foundation of their eating behaviors in later life, and have great influence on their nutritional status and health.Caregivers′ feeding practices affect children′s eating behaviors.Feeding practices are modifiable and can be used as an intervention.In recent years, responsive feeding practices have been extensively recommended.In order to expand knowledge of responsive feeding practices, and promote optimal feeding practices and children′s healthy eating behaviors, evidence about the associations between responsive feeding and infant and toddler′s eating behaviors was summarized in this paper.

High-risk human papillomavirus (HPV) persistent infection is the most common cause of cervical cancer and precancerous lesions. As a primary prevention measure, especially in developing countries, HPV vaccine can greatly reduce the incidence of cervical cancer.However, researches on the safety, efficacy, and coverage of the HPV vaccine still remain insufficient. Therefore, in this review, we outlined the recent research progress of the HPV vaccine in terms of immunogenicity, safety, efficacy, latest vaccination concepts and strategies. It may provide a theoretical basis for further research on the use of the HPV vaccine.

Objective:To understand the research status of positive psychology in the world, analyze its development trend and provide reference for the research of positive psychology in China.Methods:The research literatures on positive psychology from 2000 to 2019 were retrieved in Web of Science Core Collection database.Its built-in analytical function was used for bibliographic analysis of annual distribution, country distribution, fund supporting institutions, journal distribution, and research direction. CiteSpace 5.1.R6 software was used to draw high-frequency keywords maps to analyze research hotspots, and HistCite Pro 2.1 software was used to draw citation chronicle chart to analyze highly cited literatures.Results:A total of 4 536 literatures related to positive psychology were included, and the number of literatures showed an increasing trend year by year. The United States had the most publications, with 1 793 papers. And the number of published papers in China was 241, ranking 6th. Funding agencies and journals were scattered, but mostly from the United States. Research focused on psychology (52.491%, 2 381/4 536) , and nursing ranked 10th (1.984%, 90/4 536) . Adolescents, subjective positive experiences and personal positive traits were research hotspots.The 10 most frequently cited studies focused on positive emotions and experiences, positive psychological interventions and validation of their effectiveness.Conclusions:Positive psychology research is in a stage of continuous development and growth, and the core journal forum has not yet formed.The United States occupies a leading position in this field of research, and there is still a great room for improvement in the quantity and quality of research in this field in China.In the future, researchers can conduct in-depth studies on children, the elderly and the positive social environment, and at the same time, combine with local characteristics to explore the theoretical system and intervention mode of positive psychology suitable for China.

Objective:To explore the research hotspots and development trends of male nurses in China from 2009 to 2019 by bibliometric analysis, and provide references for related research.Methods:Relevant literature on male nurses in my country from 2009 to 2019 were retrieved through Wanfang Data, China National Knowledge Infrastructure (CNKI) , VIP, China Biology Medicine and other databases. The content of the included literature was analyzed, and word frequency analysis as well as two-way cluster analysis on keywords were performed by bicomb 2.0 software and gCLUTO 1.0 software.Results:A total of 931 journal articles were included, and 25 high-frequency keywords were obtained. Three research hotspots were obtained through cluster analysis, namely, male nurses' work advantages and management, male nurses' mental health, and male nursing students' nursing education.Conclusions:Male nurses are receiving increasing attention, and core journal forums have begun to take shape, but the overall research quality is not good. In the future, it is necessary to strengthen the scientificity and rigor of scientific research design and research implementation, so as to enhance the guiding value of literature for clinical practice.

Patients' subjective feelings, that is, patient-reported outcomes, has attracted increasing attention in patients with inflammatory bowel disease (IBD) , which plays an important role in monitoring the progress of patients' disease and guiding clinical decision-making. This article reviews the current status of assessment tools and clinical applications of patient-reported outcomes in IBD patients. This article aims to help medical and nursing staff choose assessment tools suitable for IBD patients in China, standardize the development and localization process of assessment tools, promote the application and development of patient-reported outcomes of IBD patients in China, and optimize disease management of IBD patients.