Objective To evaluate MR findings and clinical features in patients with spontaneous spinal epidural hematoma (SSEH). Methods Eight patients (5 men, 3 women; aged 16-50 years ) with SSEH underwent MR imaging during 1994-2001, including 7 cases without history of trauma or coagulation disorders and 1 case with history of hypertension. MR imaging was performed from 4 hours to 3 days after the onset of symptoms in all 8 patients with surgical and pathologic diagnosis. Results The hematomas were in lateral posterior or posterior epidural space, including 3 cases in cervical vertebra, 2 cases in thoracic vertebra, 2 cases in cervical and thoracic junction region, and 1 case in thoracic and lumbar part. The MRI confirmed an encapsulated hematoma caused by arteriovenous malformation in 1 case and two hematomas associated with disc herniation. The signal intensity of the hematoma varied with the hematoma age, but T 1-weighted images reflected its typical signal changes. Sagittal and coronal T 1- weighted images revealed isointense (7 cases) and slight high-intense (1 case) signal; Sagittal and axial T 2-weighted images revealed mixed-intensity (6 cases) and mixed high-intensity (2 cases). Conclusion MR imaging has an important value on localization, identification, and differential diagnosis of the lesion, therefore, it is the most helpful diagnostic tool for this condition.

Objective To provide a reference for the selection of frailty assessment tools for stroke patients by conducting a literature review of existing frailty assessment tools for stroke patients.Methods Systematic searches were conducted in PubMed,Web of Science,EMbase,SinoMed,Wanfang,VIP,and China National Knowledge Infrastructure(CNKI)databases from their inception to May 2023.The literature that met the research purpose and question were screened,and the basic in-formation of each article,including the first author,publication year,country of publication,type of research design,name of the assessment tool,dimensions of scale,the number of items,and assess-ment time,was extracted.Results A total of 1,729 articles were retrieved in this study.After multi-ple screenings,22 articles(including 8 frailty assessment tools)were ultimately included.The analy-sis results showed that the evaluation indicators,evaluation time,and evaluation methods of the 8 frail-ty assessment tools were different and had their own advantages and disadvantages.Among them,the frailty index was the most commonly used frailty assessment tool for stroke patients.The selection of ef-fective frailty assessment tools for stroke patients is essential for strengthening prestroke risk stratifica-tion and improving poststroke outcomes.Conclusion There are significant differences among different frailty assessment tools,and existing assessment tools have limitations in measuring frailty in stroke pa-tients.Comprehensive assessments should be conducted in combination with clinicians'experience and judgment.New frailty assessment tools are needed in future research to better guide the rehabilitation treatment and management of stroke patients.

Objective To investigate the prevalence of sarcopenia in the elderly people in a community of Chenghua District of Chengdu city and analyze its relationship with geriatric frailty syn-drome.Methods A total of 586 elderly people in a community of Chenghua District of Chengdu city were selected as research objects for comprehensive geriatric assessment,including general data sur-vey,anthropometric measurements(height,weight,grip strength,pace and skeletal muscle),and frailty screening scale survey.Incidence conditions of sarcopenia and geriatric frailty syndrome were evaluated,and the relationship between sarcopenia and geriatric frailty syndrome was analyzed.Results Totally 83 cases were diagnosed as sarcopenia,and the prevalence of sarcopenia was 14.98％.There were no significant differences in gender,education level,smoking,alcohol con-sumption and basic diseases between the sarcopenia group and the normal group(P＞0.05).Com-pared with the normal group,the sarcopenia group had a significant lower ratio of patients aged 60 to 74 years old,a significant higher ratio of patients aged 75 to 84 years old and ≥85 years old,and a significant higher incidence of geriatric frailty syndrome(P＜0.05).Compared with the normal group,the sarcopenia group had significant lower grip strength,pace,skeletal muscle mass of the four limbs,and appendicular skeletal muscle index(ASMI)(P＜0.05).Multivariate analysis showed that age,body mass index(BMI)and geriatric frailty syndrome were influencing factors for sarcopenia(P＜0.05).Conclusion Prevalence of sarcopenia in the elderly people in a community of Chenghua District of Chengdu city is relatively high,and sarcopenia is closely correlated with the occurrence of geriatric frailty syndrome.

Objective To provide a reference for the selection of frailty assessment tools for stroke patients by conducting a literature review of existing frailty assessment tools for stroke patients.Methods Systematic searches were conducted in PubMed,Web of Science,EMbase,SinoMed,Wanfang,VIP,and China National Knowledge Infrastructure(CNKI)databases from their inception to May 2023.The literature that met the research purpose and question were screened,and the basic in-formation of each article,including the first author,publication year,country of publication,type of research design,name of the assessment tool,dimensions of scale,the number of items,and assess-ment time,was extracted.Results A total of 1,729 articles were retrieved in this study.After multi-ple screenings,22 articles(including 8 frailty assessment tools)were ultimately included.The analy-sis results showed that the evaluation indicators,evaluation time,and evaluation methods of the 8 frail-ty assessment tools were different and had their own advantages and disadvantages.Among them,the frailty index was the most commonly used frailty assessment tool for stroke patients.The selection of ef-fective frailty assessment tools for stroke patients is essential for strengthening prestroke risk stratifica-tion and improving poststroke outcomes.Conclusion There are significant differences among different frailty assessment tools,and existing assessment tools have limitations in measuring frailty in stroke pa-tients.Comprehensive assessments should be conducted in combination with clinicians'experience and judgment.New frailty assessment tools are needed in future research to better guide the rehabilitation treatment and management of stroke patients.

Objective To investigate the prevalence of sarcopenia in the elderly people in a community of Chenghua District of Chengdu city and analyze its relationship with geriatric frailty syn-drome.Methods A total of 586 elderly people in a community of Chenghua District of Chengdu city were selected as research objects for comprehensive geriatric assessment,including general data sur-vey,anthropometric measurements(height,weight,grip strength,pace and skeletal muscle),and frailty screening scale survey.Incidence conditions of sarcopenia and geriatric frailty syndrome were evaluated,and the relationship between sarcopenia and geriatric frailty syndrome was analyzed.Results Totally 83 cases were diagnosed as sarcopenia,and the prevalence of sarcopenia was 14.98％.There were no significant differences in gender,education level,smoking,alcohol con-sumption and basic diseases between the sarcopenia group and the normal group(P＞0.05).Com-pared with the normal group,the sarcopenia group had a significant lower ratio of patients aged 60 to 74 years old,a significant higher ratio of patients aged 75 to 84 years old and ≥85 years old,and a significant higher incidence of geriatric frailty syndrome(P＜0.05).Compared with the normal group,the sarcopenia group had significant lower grip strength,pace,skeletal muscle mass of the four limbs,and appendicular skeletal muscle index(ASMI)(P＜0.05).Multivariate analysis showed that age,body mass index(BMI)and geriatric frailty syndrome were influencing factors for sarcopenia(P＜0.05).Conclusion Prevalence of sarcopenia in the elderly people in a community of Chenghua District of Chengdu city is relatively high,and sarcopenia is closely correlated with the occurrence of geriatric frailty syndrome.

Attention deficit hyperactivity disorder (ADHD) is a common childhood neuropsychiatric disorder that has been linked to the dopaminergic system. This study aimed to investigate the effects of regulation of the dopamine D4 receptor (DRD4) on functional brain activity during the resting state in ADHD children using the methods of regional homogeneity (ReHo) and functional connectivity (FC). Resting-state functional magnetic resonance imaging data were analyzed in 49 children with ADHD. All participants were classified as either carriers of the DRD4 4-repeat/4-repeat (4R/4R) allele (n = 30) or the DRD4 2-repeat (2R) allele (n = 19). The results showed that participants with the DRD4 2R allele had decreased ReHo bilaterally in the posterior lobes of the cerebellum, while ReHo was increased in the left angular gyrus. Compared with participants carrying the DRD4 4R/4R allele, those with the DRD4 2R allele showed decreased FC to the left angular gyrus in the left striatum, right inferior frontal gyrus, and bilateral lobes of the cerebellum. The increased FC regions included the left superior frontal gyrus, medial frontal gyrus, and rectus gyrus. These data suggest that the DRD4 polymorphisms are associated with localized brain activity and specific functional connections, including abnormality in the frontal-striatal-cerebellar loop. Our study not only enhances the understanding of the correlation between the cerebellar lobes and ADHD, but also provides an imaging basis for explaining the neural mechanisms underlying ADHD in children.
Attention Deficit Disorder with Hyperactivity ; diagnostic imaging ; genetics ; pathology ; Brain ; diagnostic imaging ; Cerebellum ; diagnostic imaging ; Child ; Corpus Striatum ; diagnostic imaging ; Female ; Frontal Lobe ; diagnostic imaging ; Genotype ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Minisatellite Repeats ; genetics ; Neural Pathways ; diagnostic imaging ; Oxygen ; blood ; Receptors, Dopamine D4 ; genetics ; metabolism ; Rest

Idiopathic pulmonary fibrosis (IPF) is a common chronic interstitial fibrotic disease. During the fibrosis process, myofibroblasts are abnormally activated, collagen is deposited in large quantities and the biomechanical characteristics of lung tissue are significantly altered. In this paper, a systematic review about the changes in lung tissues, cellular biomechanical properties and biomechanical signals during the process of IPF was presented, and the in vitro reproduction of biomechanical features and therapeutic strategies for targeting biomechanics wassummarized, so as to provide references for clinical prevention and treatment of IPF.

A great number of studies have demonstrated functional abnormalities in children with attention-deficit/hyperactivity disorder (ADHD), although conflicting results have also been reported. And few studies analyzed homotopic functional connectivity between hemispheres. In this study, resting-state functional magnetic resonance imaging (MRI) data were recorded from 45 medication-naïve ADHD children and 26 healthy controls. The regional homogeneity (ReHo), degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) values were compared between the two groups to depict the intrinsic brain activities. We found that ADHD children exhibited significantly lower ReHo and DC values in the right middle frontal gyrus and the two values correlated with each other; moreover, lower VMHC values were found in the bilateral occipital lobes of ADHD children, which was negatively related with anxiety scores of Conners' Parent Rating Scale (CPRS-R) and positively related with completed categories of Wisconsin Card Sorting Test (WCST). Our results might suggest that less spontaneous neuronal activities of the right middle frontal gyrus and the bilateral occipital lobes in ADHD children.

Idiopathic pulmonary fibrosis (IPF) is a progressive scar-forming disease with a high mortality rate that has received widespread attention. Epithelial mesenchymal transition (EMT) is an important part of the pulmonary fibrosis process, and changes in the biomechanical properties of lung tissue have an important impact on it. In this paper, we summarize the changes in the biomechanical microenvironment of lung tissue in IPF-EMT in recent years, and provide a systematic review on the effects of alterations in the mechanical microenvironment in pulmonary fibrosis on the process of EMT, the effects of mechanical factors on the behavior of alveolar epithelial cells in EMT and the biomechanical signaling in EMT, in order to provide new references for the research on the prevention and treatment of IPF.
Humans ; Epithelial-Mesenchymal Transition ; Idiopathic Pulmonary Fibrosis ; Signal Transduction