Meigs' syndrome is a benign ovarian tumor associated with ascites and pleural effusion. Elevated CA 125 in Meigs'syndrome is unusual clinical condition reported in few cases. We report here, a 49-year-old postmenopausal woman with right ovarian fibrothecoma with ascites, right pleural effusion and high serum levels of CA 125. Although postmenopausal women with ovarian tumor, ascites, pleural effusion, and elevation of CA 125 levels probably have malignant ovarian tumors, Meigs' syndrome must be considered in the differential diagnosis.
Ascites ; Diagnosis, Differential ; Female ; Humans ; Meigs Syndrome ; Middle Aged ; Ovary ; Pleural Effusion

Meigs' syndrome is defined by the presence of ascites and hydrothorax in association with an ovarian fibroma, which spontaneously resolve soon after the removal of the tumor. Pseudo-Meigs' syndrome is rare syndrome associated with struma ovarii, yolk sac tumor, ovarian carcinoma, leiomyoma, Brenner tumor and tuberculosis which is combined with the same clinical feature. The cause and pathophysiology of Pseudo-Meigs' syndrome are uncertain. The diagnosis is done by characteristic clinical finding. We present a case of Pseudo-Meigs' syndrome with Brenner tumor with brief review of the literatures.
Ascites ; Brenner Tumor* ; Diagnosis ; Endodermal Sinus Tumor ; Female ; Fibroma ; Hydrothorax ; Leiomyoma ; Meigs Syndrome ; Struma Ovarii ; Tuberculosis

Meigs' syndrome is defined by the presence of ascites and hydrothorax in association with an ovarian fibroma, which spontaneously resolve soon after the removal of the tumor. Pseudo-Meigs' syndrome is rare syndrome associated with struma ovarii, yolk sac tumor, ovarian carcinoma, leiomyoma, Brenner tumor and tuberculosis which is combined with the same clinical feature. The cause and pathophysiology of Pseudo-Meigs' syndrome are uncertain. The diagnosis is done by characteristic clinical finding. We present a case of Pseudo-Meigs' syndrome with Brenner tumor with brief review of the literatures.
Ascites ; Brenner Tumor* ; Diagnosis ; Endodermal Sinus Tumor ; Female ; Fibroma ; Hydrothorax ; Leiomyoma ; Meigs Syndrome ; Struma Ovarii ; Tuberculosis

Meigs' syndrome (MS), a rare complication of benign ovarian tumors, is easily misdiagnosed as ovarian cancer (OC). We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018. Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibroma (OTF) and healthy control groups (all P < 0.05). However, the serum HE4 levels were lower in the MS group than in the OC group (P < 0.001). A routine blood test showed that the absolute counts and percentages of lymphocytes were significantly lower in the MS group than in the OTF and control groups (all P < 0.05). However, these variables were higher in the MS group than in the OC group (both P < 0.05). The neutrophil-to-lymphocyte ratio (NLR) was also significantly lower, whereas the lymphocyte-to-monocyte ratio was higher in the MS group than in the OC group (both P < 0.05). The NLR, platelet-to-lymphocyte ratio, and systemic immune index were significantly higher in the MS group than in the OTF and control groups (all P < 0.05). The hypoxia-inducible factor-1 mRNA levels were also significantly higher, whereas the glucose transporter 1, lactate dehydrogenase, and enolase 1 mRNA levels were lower in peripheral CD4
Carcinoma, Ovarian Epithelial ; Female ; Fibroma ; Humans ; Laboratories ; Meigs Syndrome/diagnosis* ; Ovarian Neoplasms ; Retrospective Studies

Meigs' syndrome is defined by the presence of ascites and hydrothorax in association with "fibroma-like" benign ovarian tumors. Tumor extirpation resulted in a resorption of the ascites and a pleural effusion. A Krukenberg tumor resulting from stomach cancer would be highly suggested when stomach cancer, ovarian tumor, and ascites are found concomitantly. However, when a patient presents with ovarian tumor, stomach cancer, and repeated cytologic examination of the ascitic fluid renders negative results, stomach cancer associated with Meigs' syndrome should be considered in the differential diagnosis. We report a case of stomach cancer presenting with Meigs' syndrome in a 70-year-old woman who had been referred for control of intractable ascites. The patient was cured by radical subtotal gastrectomy and bilateral oophorectomy.
Aged ; Ascites ; Ascitic Fluid ; Diagnosis, Differential ; Female ; Gastrectomy ; Humans ; Hydrothorax ; Krukenberg Tumor ; Meigs Syndrome* ; Ovariectomy ; Pleural Effusion ; Stomach Neoplasms* ; Stomach*

Meigs' syndrome is a fibroma associated with ascites and/or pleural effusion and several cases have been reported in association with elevated serum cancer antigen (CA) 125 level. We report here on a 72-year-old woman who presented with palpable huge pelvic mass. Abdomen and pelvic computed tomography showed a heterogenous huge pelvic mass measuring 210×110 mm with large amount of ascites. No pleural effusion was detected on chest X-ray. CA 125 level was 327 IU/mL. The patient underwent laparotomy during which a mass measuring 210×110 mm was detected in her right ovary with 1,000 mL of ascites. Histology showed ovarian fibroma. We performed total abdominal hysterectomy with bilateral salpingo-oophorectomy. Postmenopausal woman with ovarian tumor, ascites, and elevated CA 125 may indicate malignant ovarian tumor, but Meigs' syndrome must be considered as differential diagnosis.
Abdomen ; Aged ; Ascites ; CA-125 Antigen ; Diagnosis, Differential ; Female ; Fibroma ; Humans ; Hysterectomy ; Laparotomy ; Meigs Syndrome* ; Ovary ; Pleural Effusion ; Thorax

Meigs' syndrome is a benign ovarian tumor associated with ascites and pleural effusion. Elevated cancer antigen 125 (CA-125) in Meigs' syndrome is an unusual clinical condition reported in few cases. We report here on a 61-year-old woman who presented with dyspnea; in imaging assessment, a heterogeneous pelvic mass measuring 12 x 11 cm with ascitic fluid was reported. Pleural effusion was detected on Chest X-ray. Aspiration of pleural fluid showed no evidence of malignancy. CA-125 level was 347 IU/mL. The patient underwent laparotomy during which a mass measuring 12 x 11 cm was detected in her left adnexa. Histology showed ovarian thecoma. The mass was resected, and, after that, the symptoms disappeared and CA-125 level reached 19 IU/mL. The patient had experienced no problem after 12 months of follow up. Although postmenopausal women with ovarian tumor, ascites, pleural effusion, and elevation of CA-125 levels probably have malignant ovarian tumors, Meigs' syndrome must be considered in the differential diagnosis.
Ascites ; Ascitic Fluid ; Diagnosis, Differential ; Dyspnea ; Female ; Follow-Up Studies ; Humans ; Laparotomy ; Meigs Syndrome* ; Middle Aged ; Pleural Effusion ; Thecoma ; Thorax