1.Effects of chemotherapy dose intensity on short-term efficacy in patients with advanced colon cancer: a study based on real-world data
Xuelei CHU ; Yun MAO ; Peng XUE ; Linlu LI ; Meichi CHEN ; Chunsheng YUAN ; Xiaoyan QIN ; Shijie ZHU
Journal of International Oncology 2022;49(7):408-415
Objective:To investigate the effects of different chemotherapy dose intensity on the short-term efficacy and adverse reactions of patients with advanced colon cancer.Methods:A real-world database of patients with advanced colon cancer in Wangjing Hospital of China Academy of Chinese Medical Sciences and China-Japan Friendship Hospital from January 2017 to December 2020 was established, including 105 patients treated with the same chemotherapy regimen for two consecutive cycles. The patients were grouped according to the average relative dose intensity (ARDI) of chemotherapy, and the population differences, treatment regimens, short-term efficacy and adverse reactions of different chemotherapy dose intensities were evaluated. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of ARDI for short-term efficacy.Results:There were 31 patients in the high dose intensity group (ARDI≥80%) , 34 patients in the medium dose intensity group (80%