1.Clinical observation of diclofenac sodium eye drops for postoperative recurrence of pterygium
Zhi-Rong, XU ; Hao, YAN ; Mei, FENG
International Eye Science 2014;(9):1712-1714
To observe the clinical efficacy of diclofenac sodium eye drops for postoperative recurrence of pterygium, and to provide safer drug regimens to prevent the recurrence of pterygium.
● METHODS: From November 2011 to September 2013, 124 patients 134 eyes who underwent surgery because of pterygium in our hospital were randomly divided into trial group ( diclofenac sodium eye drops and sodium hyaluronate eye drops) and control group ( tobramycin dexamethasone eye drops and sodium hyaluronate eye drops), all patients were followed up for 3mo ( once a week ) and the cornea, intraocular pressure and recurrence of pterygium were observed and compared between the two groups.
●RESULTS: Followed up for 3mo, 43 cases (45 eyes) in the trial group and 38 cases (39 eyes) in the control group had done the follow up as planned, in which 14 cases (15 eyes) showed the signs of recurrence, 2 cases (3 eyes) recurred eventually in the trial group, and in the meantime there were 12 cases (13 eyes) with signs of recurrence and 2 cases ( 2 eyes ) with a recurrence eventually in the control group, but no statistical difference was found between the two groups (P>0. 05);there were 6 cases (9 eyes) dropped out of the study with a higher intraocular pressure in the control group, compared to trial group (0 cases of 0 eye), the difference was statistically significant ( P < 0. 05); cornea conditions between the two groups had no statistical significance (P>0. 05).
●CONCLUSlON:Diclofenac sodium eye drops is effective and safe in preventing the recurrence of pterygium.
2.The methods to raising teaching quality of water-electrolyte metabolism and acid-base balance disorders
Chinese Journal of Medical Education Research 2002;0(01):-
This article has shown the experiences to achieve more effective teaching results by integration of multiple teaching patterns,including case-based,problem-based learning,in the teaching of water-electrolyte metabolism and acid-base balance disorders.
3.Analysis of TCM Decoction Prescriptions for Lung Cancer in Our Hospital in 2014
Mei YAN ; Feibao TAO ; Bin XU ; Feila XU
China Pharmacy 2015;(23):3197-3199
OBJECTIVE:To provide reference for lung cancer therapy in the filed of TCM and offer guidance for pharmacy work. METHODS:266 lung cancer prescriptions were collected from the department of TCM of our hospital during Jan. to Dec. in 2014,in-vestigated and analyzed in respects of patient’s age,the number of TCM ingredient,the weight and number of dose,cost,drug catego-ries,the frequency of each ingredient use. RESULTS:The high-risk population of lung cancer were over 40 years old group;the num-ber of TCM ingredient were from 16 to 20;the weight of dose was from 200 g to 300 g;the average number of dose was 10.01 with 53.79 yuan in average. Top 3 TCM were tonics (16.5%),TCM for relieving cough,reducing phlegm and preventing asthma (13.5%),TCM for clearing heat(11.5%). Fritillaria thunbergii,Morus alba,Citrus reticulate and Tetrastigma hemsleyanum took up the front place in the list of frequency. CONCLUSIONS:TCM for relieving cough,reducing phlegm and preventing asthma(13.5%) and TCM for clearing heat are frequently used in TCM prescription for lung cancer;all of them are easily damaged by worms,mildew, rot and extensive diffusion of oil. The management should be strengthened.
4.High IgE syndrome and its oral manifestatiom.
Li-mei GAO ; Hong-yan LIU ; Bao-hua XU
Chinese Journal of Stomatology 2011;46(12):771-773
6.Human lymphocyte damage and phosphorylation of H2AX and ATM induced by γ-rays
Mei TIAN ; Yan PAN ; Jianxiang LIU ; Jianlei RUAN ; Xu SU
Chinese Journal of Radiological Medicine and Protection 2011;31(2):126-129
Objective To investigate 60Co γ-ray induced damage in lymphocytes and the relationship between doses of 60Co γ-ray irradiation and the levels of phosphorylated H2AX and ATM.Methods Cells were irradiated with 60Co γ-rays in the range of 0-8 Gy.The levels of phosphorylated H2AX and ATM were detected by Western blot and FACScan,respectively.The micronucleus(MN)was analyzed by CB method to evaluate DNA damage.Results FACScan results showed the dose-effect relationship of γ-H2AX expression were linear.square at 0.5 h post-irradiation to different doses,and the fitting curve was shown as Y=3.96+11.29D-0.45D2.The level of phosphorylated ATM(p-ATM)was not changed significantly by using the same method.Western blot showed that p-ATM protein expression was significandy increased after irradiation compared with sham.irradiated group.The MN assay which represented DNA damage was sensitive to different doses.Conclusions γ-ray irradiation could induce the phosphorylation of H2AX and ATM,which may play an important role in indicating DNA damage.Both of H2AX and ATM have the potential as sensitive biomarker and biodosimeter for radiation damage.
7.Effects of 60Co γ-ray partial radiation on chromosome aberration in human peripheral blood in vitro
Jianxiang LIU ; Jianlei RUAN ; Mei TIAN ; Yan PAN ; Xu SU
Chinese Journal of Radiological Medicine and Protection 2011;31(1):38-40
Objective To investigate the effects of 60Co γ-ray partial radiation on chromosome aberration in human peripheral blood in vitro.Methods The samples of heparinized peripheral whole blood from 3 healthy persons were exposed to 60Co γ-rays at the doses between 0 and 8 Gy with the dose rate of 0.35 Gy/min at the temperature of 37 ℃ ,and then mixed with the unirradiated blood samples of the Microscopy was used to observe the chromosome aberration double ( centromere + centromere) and the biological dose was estimated thereby.ResultsThe amounts of double centromere + centromere were increased along with the dose of irradiation in all groups.The estimated biological dose was higher than the 1/3 of the irradiation dose when the dose was between 0.5 to 2 Gy,and was close to the 1/3 of the irradiation dose when the dose was between 4 to 8 Gy.Conclusion Chromosome aberration can be used as a biomarker in estimation of uneven irradiation.
8.Review of cases of acute thallium poisoning at home and abroad for nearly 40 years.
Xi-xian XU ; Yan-lin ZHANG ; Za-mei ZHAO
Chinese Journal of Industrial Hygiene and Occupational Diseases 2010;28(3):233-235
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Female
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Heavy Metal Poisoning
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Humans
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Male
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Middle Aged
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Poisoning
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diagnosis
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therapy
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Prognosis
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Thallium
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poisoning
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Treatment Outcome
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Young Adult
9.Drug-induced Renal Injury Caused by Antibacterial Drugs
Kexin LIU ; Mei GUAN ; Yu YAN ; Ting XU
China Pharmacist 2015;(3):476-479
At present, antibacterial drugs are widely used in the clinical treatment of infectious diseases. It is particularly impor-tant to focus on the safety of antibacterial drugs for the application improvement in the clinical treatment. The paper reviewed and sys-tematically analyzed the relative literatures in order to explain the pathomechanism of drug-induced renal injury caused by antibacterial drugs and propose some preventive measures. The study suggested that attention should be paid to the distribution and characteristics of the adverse drug reaction of antibacterial drugs to ensure the safe and proper administration of the drugs.
10.Evaluation of postoperative radiotherapy for parotid gland carcinoma
Fengyun FAN ; Wensheng WEI ; Yan GUO ; Mei SHI ; Demen XU
Journal of Practical Stomatology 2000;0(06):-
Objective: To evaluate the efficacy of postoperative radiotherapy in the treatment of parotid gland carcinoma. Methods: Eighty-six postoperated patients with parotid gland carcinoma( 7 in stage Ⅰ, 28 in stage Ⅱ, 33 in stage Ⅲ and 18 in stage Ⅳ) were radiated by 60Co ?-ray or linear accelerator X-ray combined with electron beam. All patients were diagnosed by pathology and followed up for more than 5 years. Results: The five year survival rate and the local control rate were 73.3% and 87.2% respectively. Poor prognosis was observed in the cases with the neoplastic classification of undifferentiated carcinoma, sequamous cell carcinoma and malignant pleomorphic adenoma, but the better prognosis was obtained in the cases with acinic cell carcinoma and mucoepidermoid carcinoma. Poor prognosis was observed in the cases with stage Ⅲ and Ⅳ of clinical stage. Radiotherapy undertaken in 2 weeks after surgical operation gave higher 5- year survival ratio( 83.8%). The group given 51~60 Gy radiation showed 82.9% of five- year survival rate. Conclusion: The combination of surgery with radiation is effective in the treatment of parotid gland carcinoma.Radiation of 51~60 Gy 2 weeks after operation may result in better prognosis. Neoplastic type and clinical stage are important factors for prognosis.