1.Game Analysis of the Definition of "New Drugs"
China Pharmacy 2005;0(16):-
OBJECTIVE:To provide reference for definition and research & development of new drugs in China.METHODS:The history of the definition for new drugs was reviewed,and the effects of the definition of new drugs on the research and development of drugs were discussed by using the game theory "Tragedy of the Commons" and "Anti-Tragedy of the Commons".RESULTS & CONCLUSIONS:The definition of new drugs should be more and more scientific and reasonable and in line with the aim of building new creative country,meanwhile,efforts should be paid to avoid the above mentioned two kinds of tragedies.
2.Nutrition management of extremely low birth weight infants
International Journal of Pediatrics 2016;43(12):913-915
Because of immature gastrointestinal tract development and the influence of postnatal disease status,extremely low birth weight infant feeding has become a majoy problem. Early positive parenteral feeding and proper enteral feeding are very helpful to the growth and development of extremely low birth weight infant.
3.Study on Preventive Effects of Arhinhor-11 on Acute Alcoholism in Mice
China Pharmacy 2016;27(19):2654-2656
OBJECTIVE:To study the preventive effects of arhinhor-11 on acute alcoholism in mice. METHODS:48 mice were randomly divided into model group (sodium carboxymethyl cellulose),arhinhor-11 low-dose,medium-dose and high-dose groups [1.23,2.46,4.92 g(crude drug)/kg],with 12 mice in each group. Each group was given relevant medicine intragastrically, and 30 min later given 56% liquor intragastrically to induce acute alcoholism model. The disappearance time and recovery time of righting reflex were determined. 160 mice were grouped,given medicine and modeled with the same method,with 40 mice in each group. The alcohol concentration and alcohol dehydrogenase(ADH)activity in liver of 10 mice were determined 0.5,1,2,3 h af-ter giving alcohol. Other 10 mice were included in normal control (ig administration of sodium carboxymethyl cellulose). RE-SULTS:Compared with model group,the disappearance time of righting reflex were prolonged while recovery time shortened in arhinhor-11 groups,and alcohol concentration and ADH activity increased 0.5,1,2,3 h after giving alcohol (P<0.05 or P<0.01),especially 1 h after giving alcohol. 3 h after giving alcohol,alcohol concentration in blood of arhinhor-11 high-dose group decreased while ADH activity increased (P<0.05);there was no statistical significance among other arhinhor-11 groups (P>0.05). CONCLUSIONS:Arhinhor-11 has preventive effect on acute alcoholism in mice. It has a positive control effects on the alco-hol concentration in blood and ADH activity in liver.
5.Rhabdomyolosis and its pathogenesis
World Journal of Emergency Medicine 2012;3(1):11-15
BACKGROUND: Rhabdomyolysis may cause severe damage to the human body because of acute renal failure, fatal heart rhythm disturbances, hypovolemic shock, disturbances of electrolyte balance, metabolic acidosis, hyperthermia, disseminated intravascular coagulation, etc. Drugs and toxins are the most common factors for the disease. This article aimed to review the prognosis of rhabdomyolysis. DATA SOURCES: Based on the reported studies of cell and molecular biology, we reviewed the clinical presentations, laboratory findings, and mechanisms of rhabdomyolysis in the Pubmed. RESULTS: The clinical symptoms of rhabdomyolysis were dependent on the severity of the condition and whether kidney failure develops. Since the necrosis and dissolution of muscle cells, entocytes such as myoglobin, creatine phosphokinase (CPK), electrolytes, proteins and non-protein substances were released into the plasma, the detection of the entocytes may contribute to the early diagnosis of rhabdomyolysis. CONCLUSION: Despite the etiology of the disease is multifactorial, the potential causes of rhabdomyolysis share the same pathophysiological pathway involving an increase in intracel ular calcium.
6.Clinical outcome and effect of comprehensive therapy for fungal keratitis
International Eye Science 2016;16(11):2112-2114
AIM:To explore the effect of comprehensive therapy in the treatment of fungal corneal ulcer and clinical outcome.
METHODS:A total of 159 cases 159 eyes fungal corneal ulcer patients took comprehensive therapy of 10 measures, followed up more than 3mo to observe the treatment effect and the final visual acuity in our hospital for treatment.
RESULTS: The average hospitalization time of fungal corneal ulcer was(12. 11±5. 13) d. A total of 148 cases of 148 eyes were cured, and the cure rate was 93. 1%;improvement in 8 cases, accounted for 5. 0%; 3 cases were ineffective, accounted for 1. 9%. The final visual acuity of 89 eyes ≥0. 3, accounted for 56. 0%(89/159). The final visual acuity of 136 eyes ≥0. 1, accounting for 85. 5%(136/159), and accounting for 91. 9% in 148 cured patients.
CONCLUSION: The comprehensive therapy in the treatment of fungal corneal ulcer has higher cure rate and visual acuity.
7.Effect of cerebroprotein hydrolysate on diabetic peripheral neuropathy
Hua BAI ; Mei XU ; Mei HAN ; Nan WU
Chinese Journal of Rehabilitation Theory and Practice 2004;10(4):229-230
ObjectiveTo investigate the effect of cerebroprotein hydrolysate on diabetic peripheral neuropathy.Methods105 diabetic patients were randomly divided into the treatment group (34 cases, treated with intravenous injection of cerebroprotein hydrolysate), standard control group (38 cases, treated with intramuscular injection of Metrycobal combined with intravenous injection of Actovegin) and blank control group (33 cases, treated with oral vitamin B1, B6, B12). Curative effects of three groups were evaluated.ResultsIt was shown that intravenous injection of cerebropotein hydrolysate could improve patients' symptoms, raised speed of nerve conduction and its curative effect was as same as intramuscular injection of Metrycobal combined with intravenous injection of Actovegin.ConclusionIntravenous injection of cerebropotein hydrolysate has a curation effect on diabetic peripheral neuropathy.
8.Diagnosis and prognosis of systemic juvenile rheumatoid arthritis.
Li-hua SHAO ; Min WEI ; Mei DONG
Chinese Journal of Pediatrics 2003;41(1):46-47
Arthritis, Juvenile
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classification
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diagnosis
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therapy
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Follow-Up Studies
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Humans
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Male
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Prognosis
10.Role of Fas/Fas ligand apoptotic pathway of peripheral blood lymphocytes in the development of viral myocarditis
Hua MEI ; Shaomin REN ; Ling FU
Chinese Pediatric Emergency Medicine 2011;18(4):320-322
Objective To investigate the role of peripheral blood lymphocyte apoptosis through Fas/ Fas ligand pathway in the development of viral myocarditis. Methods Twenty-five viral myocarditis (VMC) and 25 healthy children were chosen for study. The apoptosis percentage in peripheral blood iymphocytes was quantitatively examined, flow cytometry with Annexin V/PI double parameter was used. And the expressions of Fas and Fasl protein in peripheral blood lymphocytes were analyzed with flow cytometry. Results The percentage of apoptosis in peripheral blood lymphocytes in children with VMC [(0. 6976 ± 0. 1109)%] was significantly higher than that of healthy children [(0. 1288 ± 0. 1069) %] (t = 18.459, P < 0.001). Moreover, the apoptosis cell percentage showed a significant positive correlation with the serum levels of myocardium enzyme (creatine kinase-MB, lactate dehydrogenase, creatine kinase, hydroxybutyrate dehydrogenase)(r =0. 817 ,P <0. 01 ;r =0. 785 ,P <0.01 ;r =0. 726 ,P <0. 01 ;r =0. 712 ,P <0. 01). The expression of Fas and Fasl protein in VMC patients(2. 8804 ± 0. 3020,4. 4496 ± 0. 4836) were higher than those of health children(2. 1300 ±0. 6200,0. 1238 ±0. 0384) ,which had significant difference(t = 17. 321 ,P <0. 001 ;t' =44. 577, P < 0. 001). The apoptosis percentage of peripheral blood lymphocytes in children with VMC showed a significant positive correlation with the Fas and Fasl protein expression in peripheral blood lymphocytes(r =0. 972, P < 0. 01; r = 0. 958, P < 0. 01). Conclusion Apoptosis percentage of peripheral blood lymphocytes increases among children with VMC, probably because immune response decreased or it is related with the degree of myocardium damaged. Fas and Fasl play an important role in apoptosis of peripheral blood lymphocytes in children with VMC.