Objective To investigate the distribution of characteristics,clinical manifestations,laboratory parameters and activity index of patients with systemic lupus erythematosus (SLE) and to determine their role in helping to make correct clinical diagnosis and disease the activity evaluation of SLE.Methods Collect the data of 1037 SLE patients of Ningxia Medical University Affiliated Hospital from January 2006 to June 2010.Data were analyzed with t test and Chi-square test.Results Over the past three years,there were more and more patients were admitted year by year.Among the 1037 cases of SLE patients,most of them 20-40 year-old woman,accounting for 67.5％ of the whole patient population,with a male to female ratio was 1:8.26.Joint pain was the most common initial symptom,accounting for 54.3％,followed by skin rash,accounting for 48.2％.Decreased complement C3 level and platelets counts, proteinuria,and positive anti-dsDNA antibody could be used as indicators for early diagnosis of SLE.SLEDAI activity score higher than 9 were presented in 26.0％ of patients.Factors that could impact the final score of SLEADI were fever,arthritis,skin rash,proteinuria,low complement levels,high titers of anti-dsDNA antibody,pleurisy,alopecia,mucosal ulcers,pericarditis,mental illness and decreased platelets count.Patients with active disease had a higher accidence of fever,arthritis,skin rash,lung damage,alopecia,mucosal ulcers,heart damage,mental illness and renal damaged,low complement levels,high level of anti-dsDNA antibody titers and elevated erythrocyte sedimentation rate.Conclusion SLE is a multi-system disease with multiple organ involvement,with characteristic clinical symptoms and immunological abnormalities,thus early diagnosis is very important.Understanding the characteristics of the diseases,correct judgement of the disease activity,reasonable and effective treatment all can delay the development of organ damage and improve the prognosis.

Acute pancreatitis is a clinically common acute abdomen, mild acute pancreatitis is a self-limiting disease, while severe acute pancreatitis (SAP) requires multidisciplinary treatment and the mortality rate remains high. A special complication of SAP is intra-abdominal hypertension, as the disease progresses, the intra-abdominal pressure is further increased, leading to abdominal compartment syndrome (ACS), which eventually leads to multiple organ dysfunction syndrome. This current surgical intervention for SAP combined with ACS has gradually replaced the conventional medical treatment program. This article reviews the various options for surgical treatment of SAP with ACS.

OBJECTIVETo analyse the video-oculographic findings of positional tests and evaluate the efficacy of canalith repositioning procedure (CRP) in patients with paroxysmal positional vertigo ( BPPV) of the anterior semicircular canal (ASC).

METHODSA retrospective study of 31 patients with ASC BPPV. Then the CRP was performed.

RESULTSTwenty-two individuals (70.97%) presented a unilateral positional nystagmus during the Dix-Hallpike test, in 17 individuals had torsional nystagmus component, 5 individuals only had pure positional down beat nystagmus. Nine patients presented bilateral positional nystagmus, 7 individuals had torsional component positional nystagmus, in 2 patients the direction of the torsional component were the same during right and left Dix-Hallpike test, in 4 patients the torsional component were concurrent with positional down beat nystagmus but the direction could not be ascertained clinically, in 2 patients had pure positional down beat nystagmus. Nineteen patients (61.29%) had unilateral lesion, 11 patients had the left ASC BPPV, 8 patients had right ASC BPPV. Eleven patients had with both ASC and PSC BPPV in the ipsilateral. Twenty-one patients (67.74%) were cured, 29 patients (93.55%) were improved, 2 (6.45%) patients were inefficacy. CRP effectively resolved the nystagmus and vertigo in 14 patients (45.16%) when applied only once, The average number of CRP was 1.7 times, there were 5 patients recurrence during the follow-up.

CONCLUSIONSASC BPPV was not a common condition. The torsional nystagmus component of ASC BPPV might be weak during the Dix-Hallpike test. The positional nystagmus of ASC BPPV was triggered bilaterally. Based on these findings, CRP could be one of the most effective treatment methods for ASC BPPV.

Adult ; Aged ; Benign Paroxysmal Positional Vertigo ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Semicircular Canals ; Vertigo ; diagnosis ; therapy

Objective To observe the effects of mycophenolate mofetil (MMF) on the differentiation and proliferation of Helper T cells 17 (TH 17),so as to reveal its role and the possible mechanism in inducing immunological suppression.Methods Sixteen Balb/c mice of SPF level aged 8 weeks were randomly divided into two groups:MMF group and control group,with 8 mice in each group.In MMF group,the mice received intragastric administration of MMF (40 mg·kg-1· day-1 ),and those in control group received intragastric administration of identical volumetric saline every day.After three weeks,peripheral blood was collected and spleen cells were prepared.Flow cytometry was used to determine the proportions of CD4+ TH 17 and CD4+ CD25+ Tregs,then the ratio of TH 17/Tregs was calculated,and the concentrations of interleukin-1 7 (IL-1 7) and interleukin-23 (IL-23) in serum were measured by ELISA.Results The proportion of CD4+ TH 17 in the peripheral blood and spleen was (1.95 ± 0.08) and (2.42 ± 0.06) in MMF group,and (3.19 ± 0.07)％ and (4.21 ± 0.25)％ in control group,respectively.There were significant differences between the two groups (P ＜0.05).Meanwhile,the ratio of TH 17/Tregs in MMF group,both in the peripheral blood and spleen,was significantly decreased as compared with the control group (P＜0.05).The concentration of IL-17 in MMF group was lower,but that of IL-23 in MMF group was higher than in the control group (P＜0.05).Conclusion MMF could obviously suppress the differentiation and proliferation of CD4+ TH 17 in vivo,reduce the ratio of TH17/Tregs and the IL-17 secretion,thus facilitate the induction of immune tolerance.

Objective To discuss the feature of the patients' psychological status and the way to intervene through 126 patients' peri-operative period psychological status suffered from intracranial tumor and accepted Gamma knife radio-surgery.Methods The patients were randomly divided into two groups: experiment group and control group.Two groups were both evaluated by self-rating depressive scale(SDS)and self-rating anxiety scale(SAS).Results SAS score of experimental group was(36.64 ± 7.97),and SDS score was(32.16±7.98)after surgery,the scores in control group were(48.73 ±9.56)and(40.2.4 ±4.26).,respectively.The difference between the two groups was statistically significant(t =5.25,3.76; P ＜ 0.05).Conclusions Systematic psychological nursing intervention during peri-operative period can increase patients'confidence and courage; make Gamma knife radio-surgery can go on successfully.

Objective:To analyze the supply management of emergency drugs from the perspective of policy network theory and to provide a reference for the establishment of timely,reasonable and effective emergency drug management system in China.Methods:The policy network theory was used to examine the existing problems in the current supply management system of emergency drugs in China and to optimize the policy network of emergency drug supply in China.Results:The policy network theory is applicable to the emergency drug system in China.From the perspective of policy network theory,the following aspects of supply management system of emergency drugs should be improved,including a clear government responsibility at all levels,strengthening the work of medical emergency funding and legal protection,and building up a policy network of public information platform for emergency drugs.Conclusion:Based on the findings of this analysis,optimizing the supply management system of China's emergency drugs is one of the important directions of the construction of national emergency system in China.The emergency work of the drugs needs to run benignly in a network with stable structure,balance of interests and integration of resources,so as to obtain reasonable and efficient results.

The purpose of this study is to evaluate the anti-aging effects and reveal the underlying mechanism of Scutellaria baicalensis Georgi ethanol extract (SBG) in D-galactose-induced rats. Fifty rats were randomly divided into five groups: vehicle control group, D-galactose group, and D-galactose combined with 50, 100, 200 mg x kg(-1) SBG. A rat aging model was induced by injecting subcutaneously D-galactose (100 mg x kg(-1)) for ten weeks. At the tenth week, the locomotor activity (in open-field test) and the learning and memory abilities (in Morris water maze test) were examined respectively. The urine was collected using metabolic cages and analyzed by high-resolution 1H NMR spectroscopy combined with multivariate statistical analyses. The SBG at doses of 50, 100 and 200 mg x kg(-1) treatments groups could significantly ameliorate aging process in rats' cognitive performance. The 50, 100, 200 mg x kg(-1) SBG regulated citrate, pyruvate, lactate, trimethylamine (TMA), pantothenate, β-hydroxybutyrate in urine favorably toward the control group. These biochemical changes are related to the disturbance in energy metabolism, glycometabolism and microbiome metabolism, which is helpful to further understanding the D-galactose induced aging rats and the therapeutic mechanism of SBG.
Aging ; drug effects ; Animals ; Galactose ; Memory ; drug effects ; Metabolome ; Metabolomics ; Plant Extracts ; pharmacokinetics ; urine ; Rats ; Scutellaria baicalensis ; chemistry

OBJECTIVETo study human vestibular cerebral representations by combining right-sided ice-water stimulation at 0 degree C with blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI) and to evaluate the value of this method in the functional localization of human vestibular cortex.

METHODSTwenty right-handed volunteers (12 men and 8 women) received unilateral irrigation of the right external auditory meatu for 15 s with 15 ml of water at 0 degrees C during fMRI in complete darkness. The functional imaging of brain cortex was acquired with a 1.5-T MRI scanner (Signa Infinity Twin + Excite; General Electric Co., USA). The successive functional images from each subject were analyzed as a group with statistical parametric mapping software (SPM 99).

RESULTSUltimately, data obtained from 17 subjects were analyzed (3 subjects were eliminated from data because of head movement exceeding 2 mm). The group analysis showed bilateral (particularly left-sided) cortical activation, associated with caloric stimulus involving in temporoparietal junction extending into the posterior insula, supramarginal gyrus in the inferior parietal lobe, precuneus, supplementary motor area (SMA), the ventrolateral portion of the occipital lobe, cuneus and lingual gyrus, superior temporal gyrus and cingular cortex.

CONCLUSIONSIce-water stimulation at 0 degree C in fMRI reveals a widespread cortical network involved in vestibular signal processing in human. As the functional localization of vestibular cortex could be determined precisely, ice-water stimulation at 0 degree C in fMRI would hold great promise as a sensitive and reproducible tool for the research in human vestibular cortex.

Adult ; Brain Mapping ; Cerebral Cortex ; anatomy & histology ; physiology ; Ear, Inner ; Female ; Humans ; Magnetic Resonance Imaging ; methods ; Male ; Vestibular Nuclei ; anatomy & histology ; physiology ; Young Adult

Objective To investigate the sleep quality situation of patients with hepatocellular carcinoma after interventional therapy,so as to provide evidence for the intervention.Methods Randomly divided 140 patients into intervention group that received new nursing intervention on the basis of routine nursing,and control group received routine nursing,with 70 cases each group.Assessed patients' sleep quality with the Pittsburgh sleep quality index (PSQI) before and the third day after the interventional therapy.Results Before interventional therapy,the total scores of the control group and intervention group were (9.89 ±1.54) and (10.68 ± 1.47),respectively,the difference hasn' t statistical significance (P ＞ 0.05).After interventional therapy,the total score of the control group was significantly higher than that of the intervention group [(9.45±2.05) vs (6.21 ±1.36);t=-3.98,P＜0.01].Conclusions Patients with hepatocellular carcinoma after interventional therapy tend to suffer insomnia and poor quality sleep which impact the recovery and cause cancer relapse and metastasis diffusion.Specific nursing intervention can improve the patients' sleep quality effectively in the post-operative period.

Objective To explore the predictive factors and preventive nursing measures on deep venous thrombosis ( DVT) in patients with permanent pacemaker implantation after operation .Methods Four hundreds and twenty-five patients with permanent pacemaker implantation from January 2009 to December 2011 were retrospectively investigated , of which 32 patients suffered from DVT .The influencing factors on DVT in patients with permanent pacemaker implantation after operation were tested by the One -Way ANOVA analysis and multivariate logistic regression analysis .Results One-way ANOVA analysis showed that the age , BMI index, history of smoking, braking time after operation, history of DVT, diabetes, hypertension, coronary heart disease, atrial fibrillation, atrial flutter were all the risk factors on DVT in patients with permanent pacemaker implantation after operation (χ2 =8.43, 5.30, 11.86, 5.09, 17.66, 22.36, 4.69, 12.78, 32.52, respectively;P<0.05).The multivariate logistic regression analysis showed that the age , obesity, history of smoking, braking time after operation, history of DVT, all kinds of basis diseases were the predictive factors on DVT in patients with permanent pacemaker implantation after operation (OR=3.463, 3.584, 2.785, 4.844, 7.605, 4.052, respectively;P<0.05).Conclusions Appropriate preventive nursing measures aimed at the influencing factors should be taken to prevent and reduce DVT in patients with permanent pacemaker implantation after operation .