Anti-Arrhythmia Agents ; therapeutic use ; Cardiomyopathies ; drug therapy ; etiology ; Child, Preschool ; Female ; Humans ; Moricizine ; therapeutic use ; Tachycardia ; complications ; drug therapy ; Treatment Outcome

Objective To study the correlation between interrupter technique to measure airway resistance and routine pulmonary function(Raw).Methods Using Dyn′R spirometer measure Raw and FVC,PEF,MEF_ 75,MEF_ 25,MEF_ 25～75,and calculate correlation coefficient.Results There was a negative correlation between Raw and FVC, PEF, MEF_ 75,MEF_ 25,MEF_ 25～75(r

AIMTo explore the effect of remodeling and biomechanical properties after chronic treating with tetrahydrobiopterin (BH4) in spontaneously hypertensive rats.

METHODSThe spontaneously hypertensive rat(SHR) were given with BH4 chronically. The opening angle in the zero-stress state , wall-to-lumen area ratios (W/L) of thoracic aorta and the relationship between pressure and diameter (P-D) of mesenteric artery were measured by computer image analysis in 4, 16, and 26 week-old respectively.

RESULTSTreating with BH4 chronically from 4 weeks-old in SHR, there was a significant decrease in morphometric parameters of the thoracic aorta and an increase in the zero-stress state of opening angle of elastic artery. The P-D curve of mesenteric artery moved upward.

CONCLUSIONTreating with BH4 prevented the structure and function of artery from abnormal changing, including to attenuate the resistant vascular hypertrophy and recover the vascular elasticity and expansibility.

Animals ; Arteries ; physiopathology ; Arteriolosclerosis ; prevention & control ; Biomechanical Phenomena ; Biopterin ; analogs & derivatives ; therapeutic use ; Hypertension ; drug therapy ; physiopathology ; Male ; Nitric Oxide Synthase ; Random Allocation ; Rats ; Rats, Inbred SHR

The flavonoids are the active ingredients of many Chinese materia medica, with widespread biological activities and a wide range of clinical application. There are many types of flavonoids, and its chemical structure is complex. Quantitative analysis of only one or several valid / indexed components may not necessarily reflect the amount of total flavonoids, with some limitations. The content determination of total flavonoids in effective parts of Chinese materia medica is an important aspect of quality control. The main methods for determining total flavonoid content are as follows: UV-visible spectropho-tometry, fluorescence spectrophotometry, high performance liquid chromatography, capillary electrophoresis, thin layer chromatography, as well as near-infrared spectroscopy and so on. In this article, the methods and characteristics in the determination of total flavonoids in Chinese materia medica were reviewed, so as to provide references for the quality control of Chinese materia medica.

Objective To explore the effect of psychological intervention for patients underwent acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and whom were assisted by mechanical ventilator. Methods All of the 80 patients were divided into two groups randomly, there were 40 patients in each group, Both groups were given routing care, and for the intervention group, psychological intervention was added for patients and its family. Then anxiety was compared between the two groups by Hamilton Anxiety Scale (HAMA). Results Compared to the control group, the patients in the intervention group suffered fewer tracheal intubation (P<0.05 ), got less score ( P< 0.05 ), and less given up the therapy ( P < 0.05 ), then lessen the medical cost(P <0.05 ). Conclusions Psychological intervention can greatly relieve the anxiety of AECOPD patients assisted by ventilator, shorten the lCU hospital duration and reduce the medical cost.

Animals ; Fatty Liver ; genetics ; metabolism ; Female ; Liver ; metabolism ; Liver Diseases, Alcoholic ; genetics ; metabolism ; Peroxisome Proliferator-Activated Receptors ; biosynthesis ; genetics ; Random Allocation ; Rats ; Rats, Wistar

Humans ; Leptin ; blood ; Liver Cirrhosis ; blood ; etiology ; metabolism ; Liver Diseases, Alcoholic ; complications ; Male ; Transforming Growth Factor beta ; metabolism ; Transforming Growth Factor beta1

OBJECTIVETo observe the clinical efficacy of combination of traditional Chinese medicine and western medicine in the treatment of patient bitten by agkistrodon halys pallas, and the changes in peripheral blood inflammatory factors (hs-PCR, IL-6, TNF-alpha).

METHODNinty-eight patients were divided into three groups according to their hospitalization dates: the western medicine group, in which 32 patients were treated with antivenom serum (6 000 U) for five days, once every day; the traditional Chinese medicine group, in which 32 patients were treated with anti pit viper No. 2 concentrated decoction (300 mL), twice to three times every day, for five days; and the combined traditional Chinese medicine and western medicine group, in which 35 patients were treated with the combination of Chinese and Western medicine treatment described above. Then blood samples of all of patients were obtained, and serum factors (hs-PCR, IL-6, TNF-alpha) in peripheral blood were measured by Elisa assay. Another 30 health volunteers were chosen as the normal control group.

RESULTThe serum inflammatory factors were significantly higher in all patients of the three groups than that in healthy control before treatment (P < 0.01), and decreased significantly after treatment. In particular, the more remarkable reduction was found in the combined traditional Chinese medicine and western medicine group compared with the western medicine group and the traditional medicine group (P < 0.01). Symptom elimination in the three groups was superior to the western medicine group and the traditional medicine group at the first day and the third day of treatment (P < 0.05, P < 0.01). Total clinical effective rate was 100% in the combined traditional Chinese medicine and western medicine group, 84. 37% in the traditional medicine group and 65.62% in the western medicine group, the clinical effective rate of the combined traditional Chinese medicine and western medicine group was notably superior to that of the western medicine group and the traditional medicine group (P < 0.01).

CONCLUSIONThe serum inflammatory factors increased significantly in patients bitten by agkistrodon halys pallas. Treatment with the combined traditional Chinese medicine and western medicine can significantly decrease the serum inflammatory factors, and increase clinical effect, with more obvious clinical efficacy compared with the western medicine group and the traditional medicine group.

Adolescent ; Adult ; Aged ; Antivenins ; administration & dosage ; Child ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Interleukin-6 ; blood ; immunology ; Male ; Middle Aged ; Snake Bites ; blood ; drug therapy ; immunology ; Treatment Outcome ; Tumor Necrosis Factor-alpha ; blood ; immunology ; Young Adult

· AIM:To investigate the prevalence of juvenile myopia and factors affecting its occurrence in Linxia Prefecture.· METHODS:Totally 8 683 juvenile students who were 6-18 years old were extracted as respondent with stratified cluster sampling method.The eyesight,diopter and axial length were detected,and the gender,age,ethnicity,eye behavior were collected by self-made questionnaire.· RESULTS:The prevalence of myopia was 42.80％.The myopic rates of all ethnic groups were as follows:Tibetan Nationality:59.05％,Han Nationality:46.71％,Dongxiang Nationality:46.36％,Tu Nationality:45.24％,Sala Nationality:41.30％,Baoan nationality:40.61％,Hui Nationality:31.97％.Myopia rate between each ethnic groups had statistical difference (x2 =44.08,P=0.007).Multivariate analyses revealed that outdoor activities during the break was the protect factor for myopia;age,using electronic products on weekends and holidays,using the same lighting in room while studying were risk factors for myopia.· CONCLUSION:The prevalence of myopia increase with age in Linxia.The prevalence in different ethnic groups is different.Education department and family should make joint efforts to increase the outdoor time,improve the environment for teenagers to reduce the occurrence and development of myopia.

Objective To study the cerebral infarction subtypes and brain perfusion abnormalities in patients with middle cerebral artery occlusive disease (MCAOD) based on findings in neuroradiological imaging. Methods In 116 MCAOD cases confirmed by CT angiography (CTA), the data of plain CT scanning, CT perfusion imaging, and CTA were retrospectively analyzed to identify the cerebral infarction subtypes and brain perfusion abnormalities. Results In the 116 cases enrolled in this study, CTA detected 133 middle cerebral arteries (MCA) with stenotie or occlusive lesions, which involved unilateral MCA in 99 cases and bilateral MCA in 17 cases. Severe MCAOD were found in 64 cases (including 25 with MCA occlusion and 39 with severe MCA stenosis), and moderate and mild MCA stenosis in 69 cases. CT or magnetic resonance imaging (MRI) identified multiple lacunar infarctions in 45 cases, territorial infarctions in 26 cases, watershed infarctions of different types in 38 cases, striatocapsular infarctions in 10 cases and no infarction associated with the stenotic MCA in 14 cases. CT perfusion imaging showed hypoperfusion areas in 96 cases (72.2%), including 58 cases with perfusion abnormalities involving large areas in the territory supplied by the MCA; no perfusion abnormalities were found in 37 cases. Conclusion According to the severity and location of MCA stenosis, pathogenesis of stroke and the establishment of collateral circulation, MCAOD may cause different types of cerebral infarction and brain perfusion abnormalities.