ObjectiveTo investigate the effect of psychological intervention on quality of life (QOL) of patients with mammary carcinoma.Methods64 patients with mammary carcinoma were divided into intervention group (n=36) and control group (n=28), and psychological status and QOL of patients of two groups were analyzed after treatment.ResultsThe psychological status and QOL of intervention group was better than that of control group (P<0.05～0.001).ConclusionThe psychological intervention in full stage being in hospital can improve QOL of patients with mammary carcinoma, and it is clinically significant to improve cure rate and survival rate of patients.

Objective: To analyze the challenge and measures of current status in China after dialysis therapy entered in rural medical insurance of serious diseases. Methods: Based on the recent data from renal registry network in China, the primary disease, morbidity, therapy patterns and costs of end stage renal disease (ESRD) patients were analyzed the challenge and issue. Results: The number of ESRD patients is continuous growing during recent years. Hemodialysis is the main dialysis therapy pattern of ESRD and the cost is enormous. The dialysis centers and associated physicians in China are not enough. Conclusion: Prevention of ESRD in the early stage should be recommended, and medical quality of dialysis register should be administrated. It is needed to enhance medical quality management, establish county-level blood purifying center, encourage the business insurance and use medical community, chain operation and technology export to decrease medical costs.

Many clinical researches and animal experiments proved that kineditherapy could undoubtedly improve the blood lipid level of dyslipidemia. The mechanism is that kineditherapy can regulate lipid metabolism, lipoprotein and lipoproteinic lipase. On the other hands kinesitherapy also indirectly modulates insulin, adhesion factors and cytokines to influence the blood lipid level. It is important for patients to choose suitable exercises and insist them for a long time. The effect of different activity intensity on lipid level has no distinct difference.

Heart Failure ; diagnosis ; pathology ; Humans ; Medicine, Chinese Traditional

Objective To investigate the abnormality of fluid distribution and its effect on blood pressure (BP) in hemodialysis patients. Methods One hundred and six healthy volunteers as normal controls were divided into two groups(male group and female group).ECV%?ICV%(% means a percentage of weight) and ECV/ICV were measured by bioelectrical impedance spectroscopy and calculated in 2 groups respectively.Sixty-seven stable HD patients who had been on HD for more than 2 months in our hospital were selected. Patients were divided into 4 groups (hypotension prone group, normotensive group, hypertensive group and refractory hypertensive group). ECV%, ICV% and ECV/ICV were measured and calculated as above immediately before and after HD session. The measurement was conducted by Xitron 4200 HYDRA ECF/ICF Bio-Impedance Spectrum Analyzer. Results In patients on HD, a significant decrease of ECV% and ECV/ICV, and a significant increase of ICV% were seen post-HD. The pre-HD ECV% and ECV/ICV were significantly higher than those of normal controls but dropped close to normal level after hemodialysis. Post-HD ECV% was still higher than that of normal controls[(31.6?1.0)% vs (25.3?1.6)%, P 0.05]and post-HD ECV% of these patients was significantly lower than that of normal controlsand post-HD ECV% of these patients was significantly lower than that of normal controls[(19.3?1.6)% vs (22.6?1.4)%,P

Objective:To investigate and compare the effect and the possible mechanisms of 2 hypoxia-inducible factors(HIF) 1? and 2? on renal cell carcinoma(RCC) by RNA interference(RNAi) method.Methods: Chemically synthesized HIF-1? and HIF-2? RNAi were transfected into RCC cell line A498 by liposome transient transfection.Normal proximal tubule cell line HK-2 and A498 were separately treated with medium and liposome as controls.The expressions of VEGF,ET-1,bcl-2 and Ki67 were observed by RT-PCR or Western blot 24 h after RNAi.Cell apoptosis was detected by flow cytometry and fluorescence microscopy.Results: Expressions of HIF-1? and HIF-2? RNAi were higher in A498 than those in HK-2,and the 2 genes were successfully blocked after RNAi.HIF-1? RNAi resulted in a significant decrease of ET-1,bcl-2 and Ki67 expression,with increased apoptosis and necrosis of cells.HIF-2? RNAi only resulted in a decrease of VEGF.Conclusion: Both HIF-1? and HIF-2? play important roles in regulation of angiogenesis; moreover,HIF-1? might also regulate proliferation of tumor cells,possibly through regulating anti-apoptotic genes.It is implied the existance of different transcription regulation functions and gene combining sites between HIF-1? and HIF-2?.

Objective To evaluate efficacy and adverse reactions of gensenoside Rg 3 combined with synchronous docetaxel and radiation treatment in elderly patients with non-small cell lung cancer (NSCLC).Methods 62 elderly patients with NSCLC were randomly divided into 2 groups:treatment group (n=32) were treated with radiotherapy and intravenous infusion of docetaxel and oral gensenoside-Rg3 at the same time,control group (n =30) were treated with radiotherapy and intravenous infusion of docetaxel at the same time.Objective response rate (ORR),disease control rate (DCR),the long term survival and adverse reactions were observed and compared between the two groups.Results The objective response rate and the disease control rate in treatment and control groups were 90.6％ versus 83.3％ and 96.9％ versus 90.0％ respectively,and the differences were not statistically significant (both P＞0.05).Median overall survival (OS) time and 1-,2-and 3-year survival rates in treatment and control groups were 17 months versus 10 months,56.3％ versus 43.3％,49.6％ versus 25.0％,and 27.5％ versus 15.0％,respectively,and the differences were statistically significant (x2 =4.19,P 0.04).The common adverse reactions in the two groups were myelosuppression,gastrointestinal reaction,hair loss,fatigue,joint sore.No one discontinued the treatment due to serious adverse reactions.There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusions The gensenoside-Rg3 combined with synchronous treatment with docetaxel and radiation for elderly patients with NSCLC can prolong the survival time,improve quality of life and the prognosis with no significant increase in adverse reactions.

Objective To investigate the timing of beginning dialysis in CRF patients and the factors that might contribute to dialysis.Methods 117 non-diabetic CRF patients starting their first-time dialysis in our hemodialysis center from 2001.1 to 2002.12 were surveyed.The creatinine clearance (Ccr),creatinine concentration (Scr),symptoms of uremia,comorbidity and the conditions during first hemodialysis sessions were recorded.Factors from the points of patient,society,and physician that might affect the timing of dialysis were further analyzed.Results (1)In this study,the average level of Ccr was 4.18?3.26ml/min. (2)87.18% of the patients experienced nausea or vomiting before dialysis,55% manifested worsened nutritional status.71.79% occurred with cardiac morbidity and/or neuropathy,27.35% needed urgent hemodialysis. (3)98 cases (83.76%) seemed to start dialysis too late.The predominant reason was late diagnosis of CRF (76.52%).Conclusion (1)The timing of dialysis in our patients is generally late.(2)Disease screening and medical care of chronic kidney disease are key factors that affect the timing of dialysis.

Objective To clarify the signaling mechanisms underlying angiotensin Ⅱ biphasic regulation of renal proximal Na+-HCO3- transport. Methods Different concentration Ang Ⅱ to the responses of Na+-HCO3- cotransporter (NBC) activity in isolated proximal tubules, with or without ATR, MAPK, cPLA2α, P450 blockade was compared in wild-type and Ang Ⅱ type 1a receptor (AT1aR)-deficient mice. The phospholipase of ERK was examined by Western blotting. AT1aR mRNA was examined by RT-PCR from kidney proximal tubules. Results (1)In isolated wild-type mouse, renal proximal tubules showed biphasic effects of Ang Ⅱ on NBC activity. Low concentration Ang Ⅱ (10-10 mol/L) increased NBC activity, but high concentration Ang Ⅱ (10-6 mol/L) decreased NBC activity. Olmcsartan (AT1 antagonist) blocked both stimnlatory and inhibitory effects of Ang Ⅱ on NBC activity, but PD98059 (mitogen-activated protein kinase inhibitor) blocked only the stimulatory effect of low concentration Ang Ⅱ ( 10-10 mol/L). (2)In AT1aR-deficient mice, only the stimulatory effect by high concentration of Ang Ⅱ (10-6 mol/L) was observed, which was blocked by olmesartan and PD98059. (3)In wild-type mice, pharmacological blockade of cPLA2 or P450 converted the inhibition effect by high concentration Ang Ⅱ (10-6 mol/L) to the stimulation, which was blocked by olmesanan and PD98059. These results indicated that the extracellular sigual-regulated kinase (ERK) activation via AT1 mediated only the stimulatory effect of Ang Ⅱ, while the cPLA2α/P450 activation via AT1 mediated the inhibitory effect of Ang Ⅱ independently of ERK. The analysis of ERK phosphorylation by Ang Ⅱ also supported a view that the cPLA2α/P450 pathway worked to suppress the ERK activation. Conclusions Ang Ⅱ activates ERK and cPLA2α with different concentration dependency via AT1. The balance between ERK and cPLA2α activities determines the final responses to Ang Ⅱ in intact proximal tubules.

OBJECTIVETo compare the clinical efficacy between acupuncture and intravenous administration of lipoic acid and alprostadil for distal symmetric multiple peripheral neuropathy of diabetes mellitus.

METHODSSixty patients were randomly divided into an acupuncture group (31 cases) and a medication group (29 cases). Patients in the two groups received basic treatment to control blood sugar within a safe range. On this basis, patients in the acupuncture group were treated with acupuncture at Geshu (BL 17), Weiwanxiashu (EX-B 3), Ganshu (BL 18), Pishu (BL 20), Shenshu (BL 23), Zusanli (ST 36), Taixi (KI 3), ashi points, etc. Patients in the medication group were treated with intravenous administration of lipoic acid (0.6 g) and alprostadil (10 mg). The treatment was given once a day, 10 days for a course of treatment; there was an interval of 2 days between courses, and totally 3 courses were given. The score of peripheral neuropathy of diabetes mellitus, the change of nerve conduction: velocity and clinical efficacy before and after treatment in the two groups were observed.

RESULTSAfter treatment, the score of peripheral neuropathy was significantly reduced in the two groups (both P < 0.05), which was more significant in the acupuncture group (P < 0.05). After treatment, the sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) of median nerve and common peroneal nerve were significantly increased in the two groups (all P < 0.05). Compared between two groups, the SNCV and MNCV of common peroneal nerve in the acupuncture group were significantly superior to those in the medication group (both P < 0.05); the MNCV of median nerve in the acupuncture group was significantly superior to that in the medication group (P < 0.05); the SNCV of median nerve in the acupuncture group was not significantly different from that in the medication group (P > 0.05). The total effective rate was 83.9% (26/31) in the acupuncture group, which was significantly superior to 62.1% (18/29) in the medication group (P < 0.05).

CONCLUSIONAcupuncture and conventional medication both have satisfied effects for distal symmetric multiple peripheral neuropathy of diabetes mellitus, and acupuncture is superior to medication on improving clinical signs of sensory disorder, reflection disturbance and muscle weakness, nerve conduction and clinical curative effect.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Diabetes Mellitus, Type 2 ; complications ; Diabetic Neuropathies ; etiology ; physiopathology ; therapy ; Female ; Humans ; Male ; Middle Aged ; Peripheral Nerves ; physiopathology ; Peripheral Nervous System Diseases ; etiology ; physiopathology ; therapy