3.Significance of detection of serum oxidant function in patients with silicosis.
Guo-Cai LÜ ; Jin-Mei YAO ; Juan-Wen ZHANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2010;28(1):52-53
Aged
;
Case-Control Studies
;
Humans
;
Male
;
Malondialdehyde
;
metabolism
;
Middle Aged
;
Oxidation-Reduction
;
Serum
;
metabolism
;
Silicosis
;
blood
;
Superoxide Dismutase
;
metabolism
4.Metabolites from the endophytic fungus Penicillium sp. FJ-1 of Ceriops tagal.
Pengfei JIN ; Wenjian ZUO ; Zhikai GUO ; Wenli MEI ; Haofu DAI
Acta Pharmaceutica Sinica 2013;48(11):1688-91
To investigate the chemical constituents of the endophytic fungus Penicillium sp. FJ-1 of Ceriops tagal, the chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic analysis. Their antibacterial activity was tested by paper disco diffusion method. Two compounds were isolated and identified as 7-hydroxy-deoxytalaroflavone (1), and deoxytalaroflavone (2). Compound 1 is a new compound, and compounds 1 and 2 showed weak activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus.
6.Study on the Biochemical Mechanism of Degrading Keratins by Streptomyces fradiae
Lin HUANG ; Zhi-Qiang XIONG ; Hua-Jing CAI ; Mei-Jin GUO ; Guo-Quan TU ;
Microbiology 1992;0(04):-
The biochemical mechanism of degrading keratins by S.fradiae var S-221 was primarily studied.The compounds (Na_ 2 SO_ 4 , Na_ 2 SO_ 3 and sulfdryl acohol), which respecitively enhance specific activity of keratinase, activate keratinase intensively and mainly act on the disulfide bonds reductase in the keratinase, Na_ 2 SO_ 3 activates intensively both disulfide bonds reductase and polypeptide hydrolytase at 0.01 mol/L, whereas Na_ 2 S_ 2 O_ 3 , which acts on the disulfide bonds reductase, inhibits keratinase.On the condition that substrate, keratins exists, S.fradiae var S-221 is induced to produce exo-keratinase, which is a multiproteinase, containing disulfide bonds reductase, which is a key enzyme degrading keratins, then, with polypeptidic, hydrolytase, graduately hydrolyzates denatured keratins into polypeptides, oligopeptides and free amino acids, so that keratins have been decomposed completely.Sulfur in the keratins was transferred into sulfhydryl compounds, H_ 2 S and sulfates in the course of keratinolysine.
7.Primary leiomyosarcoma upper end of tibia: report of a case.
Jin-song LIU ; Mei LI ; Guo-rui XU ; Hong ZHU ; Dian-wei LI
Chinese Journal of Pathology 2009;38(8):555-556
Actins
;
metabolism
;
Bone Neoplasms
;
metabolism
;
pathology
;
surgery
;
Desmin
;
metabolism
;
Diagnosis, Differential
;
Fibrosarcoma
;
metabolism
;
pathology
;
Humans
;
Leiomyosarcoma
;
metabolism
;
pathology
;
surgery
;
Male
;
Middle Aged
;
Neurilemmoma
;
metabolism
;
pathology
;
Tibia
;
Vimentin
;
metabolism
8.Wuling capsule played an assistant role in primary prevention of post-stroke depression: a clinical research.
Jin ZHU ; Chun-mei HU ; Si-si GUO ; Feng WANG ; Ye ZHOU ; Su-ya ZHANG
Chinese Journal of Integrated Traditional and Western Medicine 2014;34(6):676-679
OBJECTIVETo observe the primary prevention role of Wuling Capsule (WC) on poststroke depression (PSD) patients.
METHODSAcute stroke patients were recruited and randomized into 2 groups by stratification, 55 in each group. All patients received same routine treatment of cardiovascular diseases. Patients in the experimental group additionally took WC (0.33 g each pill), 3 pills per day, three times per day; while those in the control group additionally took placebos, 3 pills per day, three times per day. Two weeks consisted of one therapeutic course. The diagnosis of PSD was performed once every other week. Those in accordance with PSD diagnosis discontinued any drug therapy. Those not in accordance with PSD diagnosis continued the drug therapy for 1-12 therapeutic course(s) (in total of 6 months). If they were still not in accordance with PSD diagnosis, then they discontinued the drug therapy. The morbidity of PSD, the average time of depression occurrence, Hamilton depression rating scale (HAMD) score, and adverse reactions were observed.
RESULTSThe 1-, 3-, and 6-month morbidity of PSD was 8%, 16%, and 34% in the experimental group, while they were 19.6%, 29.4%, and 54.9% in the control group. The occurrence rate was lower in the experimental group than in the control group. Besides, there was statistical difference in the 6-month occurrence rate between the two groups (chi2 = 4.465, P < 0.05). The average time of PSD occurrence was longer in the experimental group than in the control group (14.96 +/- 8.31 weeks vs. 9.36 +/- 6.06 weeks; t=6.762, P < 0.05). The HAMD score at the PSD occurrence was 11.96 +/- 2.14 in the experimental group, lower than that of the control group (14.57 +/- 4.24), showing statistical difference (t=5.641, P < 0.05).
CONCLUSIONWC was superior to the placebos in lowering the incidence of PSD, delaying the occurrence time of PSD, attenuating the depression degree of PSD, and had certain preventive effect on the incidence of PSD.
Aged ; Capsules ; Depression ; etiology ; prevention & control ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Primary Prevention ; Stroke ; complications
9.Studies on preparation by SPG membrane emulsification method and in vitro characterization of tetradrine-tashionone II(A)-PLGA composite microspheres.
Jin LU ; Meng ZHANG ; Hua-xu ZHU ; Li-wei GUO ; Lin-mei PAN ; Ting-ming FU
China Journal of Chinese Materia Medica 2015;40(6):1091-1096
Tetradrine-tashionone II(A)-PLGA composite microspheres were prepared by the SPG membrane emulsification method, and the characterization of tetradrine-tashionone II(A) -PLGA composite microspheres were studied in this experiment. The results of IR, DSC and XRD showed that teradrine and tashionone II(A) in composite microspheres were highly dispersed in the PLGA with amorphous form. The results of tetradrine-tashionone II(A) -PLGA composite microspheres in vitro release experiment showed that the cumulative release amounts of tetradrine and tashionone II(A) were 6.44% and 3.60% in 24 h, and the cumulative release amounts of tetradrine and tashionone II(A) were 89.02% and 21.24% in 17 d. The process of drug in vitro release accorded with the model of Riger-Peppas. Tetradrine-tashionone II(A) -PLGA composite microspheres had slow-release effect, and it could significantly reduce the burst release, prolong the therapeutic time, decrease the dosage of drugs and provide a new idea and method to prepare traditional Chinese medicine compound.
Benzofurans
;
chemistry
;
Benzylisoquinolines
;
chemistry
;
Drug Carriers
;
chemistry
;
Drug Compounding
;
instrumentation
;
methods
;
Drugs, Chinese Herbal
;
chemistry
;
Kinetics
;
Lactic Acid
;
chemistry
;
Microspheres
;
Particle Size
;
Polyglycolic Acid
;
chemistry