Objective To explore the relationship between the cardiac function of pregnant women with cardiac disease and the level of N -terminal pro -B -type natriuretic peptide (NT -pro -BNP).Methods A total of 74 pregnant women with cardiac disease and 80 healthy pregnant women were enrolled in the study and the NT -pro -BNP was detected and compared.The concentrations of NT -pro -BNP in different trimester were compared among the healthy pregnant women, and the correlation between the cardiac function of pregnant women with cardiac disease and the level of NT -pro -BNP were analyzed.Results The median of concentrations of plasma NT -pro -BNP in pregnant women with cardiac disease was 352.50 pg/mL,which was significantly higher than that in healthy pregnant women 58.00 pg/mL(P <0.01 ).The cardiac function was positively correlated with the level of NT -pro -BNP (P <0.01 ).The concentration of plasma NT -pro -BNP during the late trimester(49.00 pg/mL)was significantly higher than that of the early trimester(49.00 pg/mL) among the healthy pregnant women (P <0.01 ).Conclusion It is of great clinical value for the concentration of plasma NT-pro -BNP in evaluating the cardiac function of pregnant women with cardiac disease,and the pregnancy may influence the cardiac function.

Objective To explore the influencing factors and relationship of serum 25 (OH) D levels between late-term pregnant women and newborns. Methods A total of 600 pregnant women and 600 newborns were selected in Lishui Maternal and Children Health Institution during 2016 and information were collected by questionnaires. Serum 25 (OH) D levels in pregnant women's venous bloods and newborns' cord bloods were tested respectively before and after delivery. Results Serum 25 (OH) D levels in 600 pregnant women's venous bloods before delivery were (36.25 ±14.92) nmol/L and 75.16% (451 pregnant women) had lower serum 25 (OH) D levels. Serum 25 (OH) D levels in newborns' cord bloods after delivery were (29.59±16.13) nmol/L and 82.50% (495 newborns) had lower serum 25 (OH) D levels. The relationship of serum 25 (OH) D levels between pregnant women and newborns was significant (r=0.892, P<0.05) . Vitamin D supplementation during pregnancy in pregnant women (400 IU/d) 25 (OH) D level was higher than those of not (P<0.05) . Serum 25 (OH) D levels of pregnant women were influenced by seasons (P<0.05) as higher in summer and autumn and lower in spring and winter. Conclusion Serum 25 (OH) D levels of pregnant women and newborns in Lishui were lower and different among seasons. Serum 25 (OH) D levels of pregnant women could have influence on serum 25 (OH) D levels of newborns. It should be encouraged to increase vitamin D intakes and outdoor activities, especially in spring and winter.